DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and AgaP_AGAP011610

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_320897.4	Gene:	AgaP_AGAP011610 / 1281022	VectorBaseID:	AGAP011610	Length:	512	Species:	Anopheles gambiae

Alignment Length:	547	Identity:	137/547 - (25%)
Similarity:	245/547 - (44%)	Gaps:	96/547 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQATSILK 94
            :|.| :||.|::..:..::.||.:::...:.:|.....||.::|:|||..||::....:...:..
Mosquito     7 MNST-IHGFKYLVGNKRTTIERIWWIVVCLLSLYGCGTLIHSVYIKWDKEPVVVTFGEKPVPVFT 70

  Fly    95 VPFPAITICNMNQVQRSLVANYREGSNESALLKLLCESDSWESSEADEEFSASNF------VTNN 153
            :||||:|||...:|::                |.|..:.:::... ||||....|      :...
Mosquito    71 IPFPAVTICPETKVRK----------------KDLDFTTAYQLYN-DEEFVVCLFYYRIDKLEAL 118

  Fly   154 LKISEF-----VSNHSQS-------------CERMLLFCRFSAVERNCSQLFQQILTDEGLCCVF 200
            |::.:|     ::|.|.:             .|.|.|.|.:.....:|...|::.||:.|:|..|
Mosquito   119 LQVCDFSFGIEMNNESYADDVVPLLQRMAIPFEDMFLLCGWREQVIDCRDFFKETLTEAGICYTF 183

  Fly   201 NFQPPEYL---------YKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITL 256
            |....:.|         |:..|.|.         .|..|:.:.||..:.....||..|.|.|...
Mosquito   184 NSLAADDLMRRDQLHSEYEYMAENQ---------SSKQWNMDEGYSSRAGGDTYPRRAFGAGRRA 239

  Fly   257 GFTAVLDAEMG--EYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPA 319
            |...:...::.  :|.|.: :..||||:.|:|::.|::........:..|.:..:|.:..:....
Mosquito   240 GLFVITKVQISDMDYMCGN-SFQGFKVHLHSPVQYPRMVNEFFRIPLSQEVSVSVEPLLFDTTAN 303

  Fly   320 IRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDT 384
            :|..:...|.|.:.:|:.|.::::|::.||:.|||:.:...||.|:||..|.. .:..||.||..
Mosquito   304 VRRYAPSRRLCYYNHERYLRYFKVYSKYNCDIECLSNYTLKTCGCVPFPLPRT-KDDRICGMGKA 367

  Fly   385 SCVRRA-------------QRASNRPGWAKCRQQCLPSCFDLNY----LASGFSFPLASNNFQLA 432
            ||...|             .:..|  ....|  .|||||..|.|    ..:.|.:...:.|..|.
Mosquito   368 SCADMALSVLEEMDLLHELNKTDN--FLEHC--NCLPSCNALFYNTEISQAMFDWRKLAENIHLI 428

  Fly   433 NALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEIL 497
            ..:.::...||||       :||:.|.:....::...|:::||:|.|||:|||||.|::|:.|::
Mosquito   429 AGVDDNTELSYLS-------IYFKVSRFIPIKRSELFGISDFLANCGGVLGLFMGVSILSIVELV 486

  Fly   498 YFLILKPLAELFVWKRSSHVDSEKSLK 524
            |:..||||    :.:..|.:|..::.:
Mosquito   487 YYCTLKPL----IARTRSGIDRAETAR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	130/520 (25%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	130/520 (25%)
AgaP_AGAP011610	XP_320897.4	ASC	5..488	CDD:279230	130/520 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
TreeFam	0	0.000	Not matched by this tool.
	5	4.820