DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and AgaP_AGAP011611

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_320896.4	Gene:	AgaP_AGAP011611 / 1281021	VectorBaseID:	AGAP011611	Length:	508	Species:	Anopheles gambiae

Alignment Length:	516	Identity:	133/516 - (25%)
Similarity:	233/516 - (45%)	Gaps:	83/516 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQR 110
            :|.:.|.|::...|.::.....||..:|.||..:||::..:.:.|.:..:||||:|||.:.:| :
Mosquito    10 ISYFVRVFWIAMCVLSIYGCASLIETVYDKWTRSPVVVTFAEKPTPVHDIPFPAVTICPVTKV-K 73

  Fly   111 SLVANYREGSNESALLKLLCESDSWESSEADE--------EFSASNFVTNNL---KISEFVSNHS 164
            |.|.|:      :.:.:.|....:....:.|.        :||.:.::....   .:...:...:
Mosquito    74 SKVLNF------TTIYQHLVNGGNVTDEDYDRFLAMIQVCDFSFNKYLVKQQFDDNLVHLLQEMA 132

  Fly   165 QSCERMLLFCRFSAVERNCSQLFQQILTDEGLCCVFN-------FQPPEYLYKPFANNNRNLTNS 222
            ...|.:.|.|.:.....|||.||:..||:.|:|..||       .:..|| ::.|.:.....::.
Mosquito   133 PPFEELFLMCIWRGKYVNCSDLFEPTLTERGICYTFNGLGADDILRKEEY-HQDFEHLGEKRSSE 196

  Fly   223 DGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG--EYYCSSTNGPGFKVYFHN 285
            :      |..|.||...:..|.||...:..|.|.|....|.:|:.  :|.|.: :..|::...|.
Mosquito   197 N------WSMEHGYRPNIGLKAYPRRVASPGSTAGLFVGLKSELSDMDYLCGN-SFQGYQSQLHT 254

  Fly   286 PIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPA----------IRSISRDGRQCLFKNEKELIF 340
            |.:.|::.          ..|.||.|.:|..|..          :.|.|.:.|.|.:.:|:.|.|
Mosquito   255 PNQCPQIS----------NQNIRIPMNQALTVSVDPLQITTSENVMSYSPEKRLCYYPHERYLRF 309

  Fly   341 YRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRASNRPGWA----- 400
            :|:||:.|||.|||:.|....|.|:.|..|.. :|..||.:...:|...|:......|..
Mosquito   310 FRLYTKGNCELECLSNFTLHMCGCVLFSMPRA-ANVHICGLAKLACCEEAESILQEQGLGSVDNS 373

  Fly   401 ------KCRQQCLPSCFDLNYLASGFSFPLASNNF---QLANALVESFNKSYL---SKNIAVINV 453
                  .|  .|||:|..|.|...     ::.::|   :|.:.:  ..:|:|.   |..::.:.|
Mosquito   374 TKMLLQSC--NCLPACIFLKYKTE-----ISQSHFDWRRLTDTI--HISKTYFVGSSSELSSLAV 429

  Fly   454 YFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPLAELFVWKRS 514
            |::|:.:....:|...||.:|::|.||::|||||.|::|:.|:|||..:|||.. :..:||
Mosquito   430 YYKEAQFISIKRNQLFGLNDFIANCGGILGLFMGVSLLSIVEMLYFFTMKPLIN-YCMRRS 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	126/499 (25%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	126/499 (25%)
AgaP_AGAP011611	XP_320896.4	ASC	5..475	CDD:279230	126/499 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28677
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
TreeFam	0	0.000	Not matched by this tool.
	6	5.830