DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and AgaP_AGAP012279

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_320256.4	Gene:	AgaP_AGAP012279 / 1280409	VectorBaseID:	AGAP012279	Length:	511	Species:	Anopheles gambiae

Alignment Length:	566	Identity:	144/566 - (25%)
Similarity:	245/566 - (43%)	Gaps:	131/566 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVH------------ 67
            ||||         ::.:.:::||:|:.|....:.:|:....|..|...|:.|:
Mosquito     4 SLFL---------EYCSNSTVHGIKYFGCKRRTLFEKYVAEGVCVREGIVRVNCFALAIWWIATF 59

  Fly    68 ---------LISNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREGSNES 123
                     ||.|||.||:.||||:..:.::|.:.::||||:|||...:. ||...|:.:...:.
Mosquito    60 LLSVYGCGRLIQNIYRKWEQTPVIVSFAEKSTPVWQIPFPAVTICPETKA-RSEYLNFSQVYFQM 123

  Fly   124 ALLKLLCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQ 188
                    :|:|....|:|..:.    |.:....:.:.|.|...|..|.||::......||:.|.
Mosquito   124 --------NDTWRDEMANETLNQ----TTDPACVDLLKNVSMPLESALFFCKWRNDAGLCSEFFT 176

  Fly   189 QILTDEGLCCVFNFQPP-------------EYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQL 240
            :.:|:||:|..||.|..             ||:             |:..:|.:|..|.||.|..
Mosquito   177 ETITEEGICFTFNSQSAGEMLRLDELHSDYEYI-------------SEKRQSPLWSLEKGYAENT 228

  Fly   241 PPKFYPATASGTGITLGFTAVLD--AEMGEYYCSSTNGP--GFKVYFHNPIEVPKVKEAGLISAI 301
            ....||....|.|...|...:|:  ....::.|   .||  |||:..|...|.|:|.
Mosquito   229 DLDTYPVRVLGAGARAGLYVLLNLYERDTDFIC---RGPVQGFKILLHTSSEYPQVS-------- 282

  Fly   302 GYETNYRIEM-------VRAEAV---PAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAA 356
              :..||:.:       |:.:.:   ..:|..:.:.|||.|.:|:.|.::::||:.|||.||...
Mosquito   283 --KQYYRVPLHQEVIISVKPQMITTSDGLRDYTPERRQCFFNHERHLKYFKVYTQQNCELECTTN 345

  Fly   357 FLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRA-----------SNRPGWAKCRQQCLPSC 410
            :....|.|:.|..|. .....:|......|...|:..           .:|...|||  .|||:|
Mosquito   346 YTLRKCGCVKFSMPR-DDRTEVCGASKIDCYNDAEDELLEEDVKFIVDKSRDYRAKC--NCLPAC 407

  Fly   411 FDLNYLASGFSFPLASNNFQLANA------LVESFNKSYLSKN---IAVINVYFRESVYYGNTKN 466
            ..:.|.|            :::.|      |..:|.:|...::   .|.:.:||:|:.:..:.::
Mosquito   408 TSVQYDA------------EISQADLDWKSLFSAFRQSLGEQDGAQFARLTIYFKEAQFITSKRS 460

  Fly   467 AYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPLAELFVWK 512
            ...|:|:||:|.||::|||||.|::||||::||..::|...|..::
Mosquito   461 ELYGVTDFLANCGGLLGLFMGVSLLSLAELIYFCSIRPFTILRAYR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	136/538 (25%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	136/537 (25%)
AgaP_AGAP012279	XP_320256.4	ASC	9..493	CDD:279230	136/537 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
TreeFam	0	0.000	Not matched by this tool.
	5	4.820