DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and AgaP_AGAP007945

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_317530.3	Gene:	AgaP_AGAP007945 / 1278009	VectorBaseID:	AGAP007945	Length:	455	Species:	Anopheles gambiae

Alignment Length:	540	Identity:	113/540 - (20%)
Similarity:	201/540 - (37%)	Gaps:	128/540 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 FVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGIS 86
            |...::::|..::.||:||:.|......||.|:              |..:.:.|..:..:|..|
Mosquito     3 FTEIVKEYLINSTFHGVKFIADDSYHVTERIFW--------------IVCVIISWVGSAFLIDAS 53

  Fly    87 PQA--TSIL-----------KVPFPAITICNMNQVQR-SLVANYREG-SNESALLKLLCE----- 131
            .:|  ||.:           ...||:|.:|.|..::| ..:|:...| .::.|:.::|.|
Mosquito    54 LEAFQTSAISFVVETSYRDWNTRFPSIVVCEMRNMERIQAIADRLWGEDHDFAMEEVLNEIGYFR 118

  Fly   132 SDSWESSE--ADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTDE 194
            .:|:.:..  |.|:.:.:.|..|....:|.|.:   :|...|..|.::....:|.:.||.:.|:.
Mosquito   119 GESYHTVNECAGEDMAENCFFDNFTAYAELVRS---TCMETLEDCYWNDKPFDCCRYFQPMETEL 180

  Fly   195 GLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGI-TLGF 258
            |||...|                :|..|               .::|.|....:...||. .|..
Mosquito   181 GLCYAVN----------------SLQTS---------------AKVPIKLNMISNKHTGPGKLTI 214

  Fly   259 TAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKV---KEAGLI--SAIGYETNYRIEMVRAEAVP 318
            |.:.:|               .||.....|||.:   |...|:  ..|.|:.:..|:.:  |..|
Mosquito   215 TVLTEA---------------YVYTIGEEEVPNLITPKSDVLLVDHYIAYKRHISIKDI--ENDP 262

  Fly   319 AIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC----IPFDHPLIYSNASIC 379
            ..:.:|...|:|.|.:|..|..:|.|:...|..:|........|:|    :|...|.:.     |
Mosquito   263 EAKQVSVSQRKCRFPDENNLNVHRFYSYSACSVQCRKDKQIKICNCTSHLMPNTEPHLK-----C 322

  Fly   380 SMGDTSCVRRAQRASN--RPGWAKCRQ----QCLPSCFDLNYLASGFSFPLASNNFQLANALVES 438
            :|....|:........  .|.|:..|:    .|||||.:::.                  .:|..
Mosquito   323 NMSGLICLNEHYEDLTIVIPKWSVGRRGVVCDCLPSCTEVDI------------------GIVHD 369

  Fly   439 FNKSYL--SKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLI 501
            ..:|..  .:..:.|.:...........:|...|..:.:.:|||..|||:|.|::|..||.|:..
Mosquito   370 SRESIFDSDRRYSTIEIQLSALPTERYKRNVVRGRLDLVVSVGGTTGLFVGASLLSFVEIFYYFT 434

  Fly   502 LKPLAELFVWKRSSHVDSEK 521
            ::|....::.|...:|...|
Mosquito   435 VRPYGTRYILKLKRNVGPYK 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	107/510 (21%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	107/509 (21%)
AgaP_AGAP007945	XP_317530.3	ASC	10..432	CDD:279230	107/509 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
TreeFam	0	0.000	Not matched by this tool.
	4	3.820