DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and AgaP_AGAP006703

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_309041.4	Gene:	AgaP_AGAP006703 / 1270354	VectorBaseID:	AGAP006703	Length:	529	Species:	Anopheles gambiae

Alignment Length:	532	Identity:	118/532 - (22%)
Similarity:	205/532 - (38%)	Gaps:	110/532 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEPSPSAGTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIIT 65
            |..|||..:..:.:|    ::.|::...|...:|||||:::|.:..:......   .||.::|..
Mosquito     1 MAHSPSIASALRLAS----QTVVQTFWIFCENSSLHGLRYIGRNKATKGNTPL---RFVWSVIAV 58

  Fly    66 VHLISNIYVK---WD---STPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREGSNESA 124
            |.|...:::.   ||   |.|.:..|...:..:..:.|||:|:||:|::..:.....  |:..:.
Mosquito    59 VSLGFTLFLSSSAWDQFRSNPTLTTIETTSYPVSLIAFPAVTLCNINKIHSTKAEEL--GAKLAK 121

  Fly   125 L----------------LKLLCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLF 173
            |                |..|...|. .....:|:..:..:.|..|....     :..||.||:.
Mosquito   122 LGVHINDTIDVIYSLPRLNDLRPIDQ-RIVAIEEQLRSKGYDTEQLAFEV-----APPCETMLVH 180

  Fly   174 CRFSAVERNCSQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPE 238
            |.:......|..||::.....|.||.|                    |:|.|...::. .:..|.
Mosquito   181 CFWLMQPVQCRTLFRRTKIFAGYCCSF--------------------NADRFLEPVFS-RAKEPG 224

  Fly   239 QLPPKFYPATASGTGITLGFTAVLDAEMGEYYCSSTN--GPGFKVYFHNPIEVPKVKEAGLISAI 301
            :.||: .....:|.|...|.:.::|  :||.|.:::|  ..|.:|:.|...:.|...:...|...
Mosquito   225 EAPPQ-ESLHVTGIGKGEGLSVLMD--IGEQYYTASNRFSYGIEVFVHRSFDFPDFSDYTTIVQR 286

  Fly   302 GYETNYRIEMVRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIP 366
            |.||:..:......|.|::|||:.:.|.|.|::|........||..||.|||...:....|.|||
Mosquito   287 GTETDVSVLPTLVTASPSLRSIALEKRGCAFEDEGNSTVGVPYTYSNCMNECELRYTASVCRCIP 351

  Fly   367 FDHPLIYSNAS----ICSMGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNYLASGFSFPLASN 427
            .....:...|.    ||...:..|:...:.:|..          ||   :.|:.|.|
Mosquito   352 LFKQTVELQAELKVPICGFRELGCLLDLKGSSGG----------LP---EFNFSAYG-------- 395

  Fly   428 NFQLANALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVIS 492
                                  |::|:||.:......:..:|.....::..||::||..|.|::|
Mosquito   396 ----------------------VLHVHFRSTNCLKYRREPFVTWQTLVATFGGILGLCFGGSILS 438

  Fly   493 LAEILYFLILKP 504
            |.|.|:...:.|
Mosquito   439 LIEGLFLFGVIP 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	111/498 (22%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	111/497 (22%)
AgaP_AGAP006703	XP_309041.4	ASC	25..441	CDD:279230	109/493 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
TreeFam	0	0.000	Not matched by this tool.
	5	4.820