DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and AgaP_AGAP006704

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_309040.4	Gene:	AgaP_AGAP006704 / 1270353	VectorBaseID:	AGAP006704	Length:	565	Species:	Anopheles gambiae

Alignment Length:	538	Identity:	122/538 - (22%)
Similarity:	212/538 - (39%)	Gaps:	117/538 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LKSFVRSLRQ-FLNQTSLHGLKFV-GDSGL-------SSWERSFFLGSFVTALIITVHLISNIYV 74
            :::.|||:.| |...||||||::| |::..       |...|..:|...:.::..|:.:....::
Mosquito    10 VRATVRSVVQTFCENTSLHGLRYVYGEARTGATTTPHSRMLRMLWLLVCMVSIGFTMIMGMIAWM 74

  Fly    75 KWDSTPVIIGISPQATSILKVPFPAITICNMNQVQR--------SLVANYREGSNESALLKLLCE 131
            ::.:||.|..|......|..:||||:|:||:|::..        .||..|  |.:|:....||..
Mosquito    75 RFRTTPTITTIETMTYPIWNIPFPAVTVCNINKIDSRKARIIIDRLVKEY--GMSEANATGLLIA 137

  Fly   132 SDSWESSEADEEFSASNFVTNNLKISEFVSNH-----------SQSCERMLLFCRFSAVERNCSQ 185
            ..|..:      |.|.|  |:.|::...:...           :|.||.::..|.:...|..||:
Mosquito   138 QASLVN------FEAVN--TSYLELESVLGRMGWNPDKLLLELTQPCEDLIKVCYWLGSEIPCSK 194

  Fly   186 LFQQILTDEGLCCVFNFQPPEYLYKPFA-NNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATA 249
            :.::..||.|.||.:|.   :...:|.. ..|::            ||.:.|        .|...
Mosquito   195 IIRRTRTDNGFCCSYNV---DTTMQPLVLQQNQS------------DPRTPY--------RPRRL 236

  Fly   250 SGTGITLGFTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRA 314
            ||.|..:|.:.::|.:...|...:.:..|.:||.|:..:.|...:...::..|::....:..:..
Mosquito   237 SGAGRHVGLSILIDVQPDTYMAPTKSYYGAEVYIHDSSDFPSDADFEHVAQPGWDVVMSVIPLPI 301

  Fly   315 EAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPF---DHPLIYSNA 376
            |:...:..:....|:|....|........:....|..||....:...|.|:||   |...||...
Mosquito   302 ESSSTMNQVPESMRKCFLPEESGTNGSDSFNLNVCMAECRLRTILKLCHCVPFYYADLSRIYGYF 366

  Fly   377 SICSMGDT------------SCVRRAQRASNRPGWAKCRQQCLPSCFDLNYLASGFSFPLASNNF 429
            ......||            .|                  .|.|.|..|||            |.
Mosquito   367 YSLRTDDTLDPELDDVEFGMDC------------------DCKPPCSVLNY------------NV 401

  Fly   430 QLANALVESFNKSYLSKNI--------AVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFM 486
            |  ..:.:...||::|.|.        |.:||:|::.......::||:.....::..||:.||.|
Mosquito   402 Q--TIVSQRTTKSFMSANFGGRNVSMYATLNVHFKDIYCVKYKRDAYMTWDSLVATFGGIFGLCM 464

  Fly   487 GFSVISLAEILYFLILKP 504
            |.||:|:.|::|:..:||
Mosquito   465 GGSVLSIVELVYYFTIKP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	116/522 (22%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	115/520 (22%)
AgaP_AGAP006704	XP_309040.4	ASC	21..477	CDD:279230	115/520 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
TreeFam	0	0.000	Not matched by this tool.
	5	4.820