Protein Alignment ppk12 and Asic1

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_001276720.1
• Gene: Asic1 / 11419
• MGIID: 1194915
• Length: 559
• Species: Mus musculus
• Alignment Length: 601
• Identity: 133/601 - (22%)
• Similarity: 214/601 - (35%)
• Gaps: 187/601 - (31%)

  Fly    24 RSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQ 88
            |.|..|.|..:|||...|...|.....::.:..:||.||...:..:.:....:.|.|.:..:...
Mouse    61 RDLVAFANSCTLHGASHVFVEGGPGPRQALWAVAFVIALGAFLCQVGDRVAYYLSYPHVTLLDEV 125

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLKL-----LCESDSWE---SSEADEEFS 145
            ||:  ::.|||:|.||.|.|:.|.: :|.:      ||.|     |.|||...   :....|.||
Mouse   126 ATT--ELVFPAVTFCNTNAVRLSQL-SYPD------LLYLAPMLGLDESDDPGVPLAPPGPEAFS 181

  Fly   146 ASNFVTNNLKISEFVSNHSQSCER---MLLFCRFSAVERNCS-----QLFQQILTDEGLCCVFNF 202
            ...|     .:..|   :::||.|   |||:|.:      |.     ..|..:.|..|.|..||
Mouse   182 GEPF-----NLHRF---YNRSCHRLEDMLLYCSY------CGGPCGPHNFSVVFTRYGKCYTFN- 231

  Fly   203 QPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG 267
                                        ..:.|.|.....|      .|||  .|...:||.:..
Mouse   232 ----------------------------SGQDGRPRLKTMK------GGTG--NGLEIMLDIQQD 260

  Fly   268 EYY------CSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPA----IRS 322
            ||.      ..::...|.||..|:..|.|.:.:.|...|.|::|....:..|...:|:    ..:
Mouse   261 EYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNA 325

  Fly   323 ISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC----IPFDHPLIYSNASICSMGD 383
            ::.|..           |:..|:...|..:|...:|.:.|:|    :|.|.|.
Mouse   326 VTMDSD-----------FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY------------ 367

  Fly   384 TSCVRRAQRASNRPG----------WAKCRQQC-------------LPSCFDLNYLASGFSFPLA 425
              |.....:....|.          :..|...|             :||.....|||
Mouse   368 --CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLA-------- 422

  Fly   426 SNNFQLANALVESFNKS--YLSKNIAVINVYFR----ESVYYGNTKNAY--VGLTEFLSNVGGVM 482
                       :.||||  |:.:||.|::::|.    |::   ..|.||  .||   |.::||.|
Mouse   423 -----------KKFNKSEQYIGENILVLDIFFEVLNYETI---EQKKAYEIAGL---LGDIGGQM 470

  Fly   483 GLFMGFSVISLAEILYFLILKPLAELFVWKRSSHVDSEKSLKHNAFGIEKGQS-------SDNPS 540
            |||:|.|::::.|:..:..     |:...:.......:|..|.|:  .:||.:       ..||.
Mouse   471 GLFIGASILTVLELFDYAY-----EVIKHRLCRRGKCQKEAKRNS--ADKGVALSLDDVKRHNPC 528

  Fly   541 FWHSKELYPKGVSISA 556
              .|...:|.|::.:|
Mouse   529 --ESLRGHPAGMTYAA 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	119/530 (22%)
Asic1	NP_001276720.1	ENaC	63..541	CDD:273304	131/596 (22%)