DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and Asic1

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001276720.1	Gene:	Asic1 / 11419	MGIID:	1194915	Length:	559	Species:	Mus musculus

Alignment Length:	599	Identity:	134/599 - (22%)
Similarity:	214/599 - (35%)	Gaps:	183/599 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQ 88
            |.|..|.|..:|||...|...|.....::.:..:||.||...:..:.:....:.|.|.:..:...
Mouse    61 RDLVAFANSCTLHGASHVFVEGGPGPRQALWAVAFVIALGAFLCQVGDRVAYYLSYPHVTLLDEV 125

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLKL-----LCESDSWE---SSEADEEFS 145
            ||:  ::.|||:|.||.|.|:.|.: :|.:      ||.|     |.|||...   :....|.||
Mouse   126 ATT--ELVFPAVTFCNTNAVRLSQL-SYPD------LLYLAPMLGLDESDDPGVPLAPPGPEAFS 181

  Fly   146 ASNFVTNNLKISEFVSNHSQSCER---MLLFCRFSAVERNCS-----QLFQQILTDEGLCCVFNF 202
            ...|     .:..|   :::||.|   |||:|.:      |.     ..|..:.|..|.|..||
Mouse   182 GEPF-----NLHRF---YNRSCHRLEDMLLYCSY------CGGPCGPHNFSVVFTRYGKCYTFN- 231

  Fly   203 QPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG 267
                                        ..:.|.|.....|      .|||  .|...:||.:..
Mouse   232 ----------------------------SGQDGRPRLKTMK------GGTG--NGLEIMLDIQQD 260

  Fly   268 EYY------CSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPA----IRS 322
            ||.      ..::...|.||..|:..|.|.:.:.|...|.|::|....:..|...:|:    ..:
Mouse   261 EYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNA 325

  Fly   323 ISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC----IPFDHPLIYSNASICSMGD 383
            ::.|..           |:..|:...|..:|...:|.:.|:|    :|.|.|.
Mouse   326 VTMDSD-----------FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY------------ 367

  Fly   384 TSCVRRAQRASNRPG----------WAKCRQQC-------------LPSCFDLNYLASGFSFPLA 425
              |.....:....|.          :..|...|             :||.....|||
Mouse   368 --CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLA-------- 422

  Fly   426 SNNFQLANALVESFNKS--YLSKNIAVINVYFRESVYYG--NTKNAY--VGLTEFLSNVGGVMGL 484
                       :.||||  |:.:||.|::::| |.:.|.  ..|.||  .||   |.::||.|||
Mouse   423 -----------KKFNKSEQYIGENILVLDIFF-EVLNYETIEQKKAYEIAGL---LGDIGGQMGL 472

  Fly   485 FMGFSVISLAEILYFLILKPLAELFVWKRSSHVDSEKSLKHNAFGIEKGQS-------SDNPSFW 542
            |:|.|::::.|:..:..     |:...:.......:|..|.|:  .:||.:       ..||.
Mouse   473 FIGASILTVLELFDYAY-----EVIKHRLCRRGKCQKEAKRNS--ADKGVALSLDDVKRHNPC-- 528

  Fly   543 HSKELYPKGVSISA 556
            .|...:|.|::.:|
Mouse   529 ESLRGHPAGMTYAA 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	120/529 (23%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	120/528 (23%)
Asic1	NP_001276720.1	ASC	63..541	CDD:295594	132/594 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842203
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.750