Protein Alignment ppk12 and Asic2

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_006532059.1
• Gene: Asic2 / 11418
• MGIID: 1100867
• Length: 596
• Species: Mus musculus
• Alignment Length: 590
• Identity: 143/590 - (24%)
• Similarity: 236/590 - (40%)
• Gaps: 149/590 - (25%)

  Fly     2 EPSPSA-------GTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFV----GDSGLSSWERSFFL 55
            :|:|:|       |.:|.|..........|..|..|::|.||||:.:    ..:|.|...|:.::
Mouse    26 QPAPAAVAAARQPGGDRSGDRELQGPGVARRGRPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWV 90

  Fly    56 GSFVTALIITVHLISNIYVKWDSTPVIIGIS-PQATSI-----LKVPFPAITICNMNQVQRSLVA 114
            .:|.|:|        .:.:.|.|..::..:| |..|.:     .::||||:|:||.|.::...::
Mouse    91 LAFCTSL--------GLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLS 147

  Fly   115 N---YREG-------SNESA--LLKLLCESD----SWESSEAD----------EEFSASNFVTNN 153
            .   |..|       .|.:|  |:..|...|    .|....||          |..||:
Mouse   148 KGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAA------ 206

  Fly   154 LKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTDEGLCCVFNFQ----PPEYLYKPFAN 214
                 |:.......|.|||.|::..                .||...||.    ||.   :| |.
Mouse   207 -----FMDRLGHQLEDMLLSCKYRG----------------ELCGPHNFSSVSCPPR---EP-AL 246

  Fly   215 NNRNLTNSDGFESVMWDPESGYPEQLPPKF---------------YPATASGTGITLGFTAVLDA 264
            ::..|..|.  |::.|.|.:|:...:..|:               ......|||  .|...:||.
Mouse   247 SDPALPRSP--EALRWAPGTGHQAPVFTKYGKCYMFNSGEDGKPLLTTVKGGTG--NGLEIMLDI 307

  Fly   265 EMGEYYC------SSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSI 323
            :..||..      .:|...|.||..|:..|.|.::|.|...|.|::|....:..|...:|.....
Mouse   308 QQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGE 372

  Fly   324 SRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC--------IPFDHPLIYSNASICS 380
            .|       .:|..|.|:.:|:...|..:|...::.:.|:|        .||..|..:...:..:
Mouse   373 CR-------SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPA 430

  Fly   381 MGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNYLASGFSFPLASNNFQLANALVESFNKS--Y 443
            :|     ..|::.||   :..||..|  :....|...|....|..::    |..|.:.||||  |
Mouse   431 LG-----LLAEKDSN---YCLCRTPC--NLTRYNKELSMVKIPSKTS----AKYLEKKFNKSEKY 481

  Fly   444 LSKNIAVINVYFRESVYYG--NTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEI---LYFLILK 503
            :|:||.|::::| |::.|.  ..|.|| .:...|.::||.||||:|.|::::.|:   :|.||.:
Mouse   482 ISENILVLDIFF-EALNYETIEQKKAY-EVAALLGDIGGQMGLFIGASILTILELFDYIYELIKE 544

  Fly   504 PLAEL 508
            .|.:|
Mouse   545 KLLDL 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	130/545 (24%)
Asic2	XP_006532059.1	ENaC	64..590	CDD:273304	134/552 (24%)