DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and Asic2

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_006532059.1	Gene:	Asic2 / 11418	MGIID:	1100867	Length:	596	Species:	Mus musculus

Alignment Length:	590	Identity:	143/590 - (24%)
Similarity:	236/590 - (40%)	Gaps:	149/590 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EPSPSA-------GTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFV----GDSGLSSWERSFFL 55
            :|:|:|       |.:|.|..........|..|..|::|.||||:.:    ..:|.|...|:.::
Mouse    26 QPAPAAVAAARQPGGDRSGDRELQGPGVARRGRPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWV 90

  Fly    56 GSFVTALIITVHLISNIYVKWDSTPVIIGIS-PQATSI-----LKVPFPAITICNMNQVQRSLVA 114
            .:|.|:|        .:.:.|.|..::..:| |..|.:     .::||||:|:||.|.::...::
Mouse    91 LAFCTSL--------GLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLS 147

  Fly   115 N---YREG-------SNESA--LLKLLCESD----SWESSEAD----------EEFSASNFVTNN 153
            .   |..|       .|.:|  |:..|...|    .|....||          |..||:
Mouse   148 KGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAA------ 206

  Fly   154 LKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTDEGLCCVFNFQ----PPEYLYKPFAN 214
                 |:.......|.|||.|::..                .||...||.    ||.   :| |.
Mouse   207 -----FMDRLGHQLEDMLLSCKYRG----------------ELCGPHNFSSVSCPPR---EP-AL 246

  Fly   215 NNRNLTNSDGFESVMWDPESGYPEQLPPKF---------------YPATASGTGITLGFTAVLDA 264
            ::..|..|.  |::.|.|.:|:...:..|:               ......|||  .|...:||.
Mouse   247 SDPALPRSP--EALRWAPGTGHQAPVFTKYGKCYMFNSGEDGKPLLTTVKGGTG--NGLEIMLDI 307

  Fly   265 EMGEYYC------SSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSI 323
            :..||..      .:|...|.||..|:..|.|.::|.|...|.|::|....:..|...:|.....
Mouse   308 QQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGE 372

  Fly   324 SRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC--------IPFDHPLIYSNASICS 380
            .|       .:|..|.|:.:|:...|..:|...::.:.|:|        .||..|..:...:..:
Mouse   373 CR-------SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPA 430

  Fly   381 MGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNYLASGFSFPLASNNFQLANALVESFNKS--Y 443
            :|     ..|::.||   :..||..|  :....|...|....|..::    |..|.:.||||  |
Mouse   431 LG-----LLAEKDSN---YCLCRTPC--NLTRYNKELSMVKIPSKTS----AKYLEKKFNKSEKY 481

  Fly   444 LSKNIAVINVYFRESVYYG--NTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEI---LYFLILK 503
            :|:||.|::::| |::.|.  ..|.|| .:...|.::||.||||:|.|::::.|:   :|.||.:
Mouse   482 ISENILVLDIFF-EALNYETIEQKKAY-EVAALLGDIGGQMGLFIGASILTILELFDYIYELIKE 544

  Fly   504 PLAEL 508
            .|.:|
Mouse   545 KLLDL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	130/546 (24%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	130/545 (24%)
Asic2	XP_006532059.1	ASC	64..590	CDD:383197	134/552 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842223
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.700