DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and asic5

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_017951381.2	Gene:	asic5 / 100498195	XenbaseID:	XB-GENE-983430	Length:	852	Species:	Xenopus tropicalis

Alignment Length:	525	Identity:	134/525 - (25%)
Similarity:	209/525 - (39%)	Gaps:	114/525 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LFLLKSFVRSLRQ-------FLNQTSLHGLKFV---GDSGLSSWERSFFLGSFVTALIITV--HL 68
            |:|.|..|.||.:       |...||.||:..:   |.||.:|..|:....|.|:..||..  .:
Frog   367 LYLRKHSVPSLEERKKYNHGFATSTSFHGVHNLVENGGSGKNSKFRTAIWTSVVSVFIIMACWQV 431

  Fly    69 ISNI--YVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVAN----YREGSNESALLK 127
            .:.:  |..|.:|     .|.....:..:.|||||.||:|:.|...|.|    :...:..||:|.
Frog   432 CTRVINYFSWPTT-----TSVNVQYVENIDFPAITFCNLNRFQTKAVNNLSIAFFLWNIVSAVLH 491

  Fly   128 LL-CESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCER-MLLFCRFSAVERNC-SQLFQQ 189
            .. ..||..|..|..:...    :..|..|.||..|:...... .||.|.|....  | .:.|:.
Frog   492 FTSIASDPGEMQEVTDFLK----LNKNFSIKEFTKNYGFYLNNSTLLKCSFFGYP--CYPEDFEH 550

  Fly   190 ILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWD-PESGYPEQLPPKFYPATASGTG 253
            |.|:.|.|..||       |...:.|.|..|...|. ||::| .::.:.::      |
Frog   551 IFTEYGNCYTFN-------YNTVSMNKRITTAGRGL-SVLFDIKQTEFTDE------P------- 594

  Fly   254 ITLGFTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAV- 317
             :|||   :||             |.....|:|:..|:....||.|..|...:  :.|.|.:.|
Frog   595 -SLGF---VDA-------------GISFVLHSPLVPPRFDGLGLHSPAGMHAH--VSMRRFKTVI 640

  Fly   318 ---------PAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIY 373
                     |:::                |.::.||:...|..||.:.::.:.|.||||   |:.
Frog   641 QEHPWGECNPSLK----------------LKYHEIYSTYGCLQECKSYYIQNECGCIPF---LLP 686

  Fly   374 SNASICSMGDT-SCVRRAQ---RASNRPGWAKCRQQCLPSCFDLNYLA--SGFSFPLASNNFQLA 432
            .|...|.:... :||.||.   ..|...........|...|.:.::.|  |..:||    :.:.|
Frog   687 GNGKECDLQQLYNCVSRALYTIEKSELCSMGTYNSTCPVPCEETDFPATISYSTFP----SDKAA 747

  Fly   433 NALVESFNKS--YLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAE 495
            ..|....:||  |:..|:..|::.:.|..|....:...:..:|.|||:||.:|||.|.|:|::.|
Frog   748 QFLSAKLSKSALYMRNNLVYIDIKYHEMNYKIMKQQKALTASELLSNIGGQLGLFCGASMITIIE 812

  Fly   496 ILYFL 500
            :|.:|
Frog   813 VLEYL 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	127/510 (25%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	127/502 (25%)
asic5	XP_017951381.2	Inhibitor_I29	66..129	CDD:400519
		Peptidase_C1A	158..360	CDD:239068
		ASC	387..816	CDD:395688	127/502 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010