DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and asic2

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_004918663.1	Gene:	asic2 / 100492214	XenbaseID:	XB-GENE-6033380	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	530	Identity:	129/530 - (24%)
Similarity:	209/530 - (39%)	Gaps:	131/530 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGIS-PQATSI- 92
            |....|||||::....|:...|:|:..:|.|:|        ..::.|.|..::..:| |..|.:
Frog    45 LQHIKLHGLKYICSPKLAFRHRTFWFLAFFTSL--------GFFLSWSSNRLLYWLSFPSHTRVQ 101

  Fly    93 ----LKVPFPAITICNMNQVQRSLV-------ANYREG---SNESA---LLKLLCES-DSWESSE 139
                .::.|||:|.||.|.|:...:       |.|..|   :|.:|   |.:||.|. ..|....
Frog   102 LEWSKELAFPAVTFCNNNPVRFHRLSKSDLYFAGYWLGLLFANRTARPMLAELLPEDRRKWFQKL 166

  Fly   140 ADEE--FSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTDEGLCCVFNF 202
            ||..  ....||  :.:.:. |:.......|.|||.|::.. |......|..:.|..|.|.:||
Frog   167 ADFRLFLPPRNF--DGISVG-FMDRLGHQLEDMLLSCKYRG-EACGPHNFSTVFTRYGKCYMFN- 226

  Fly   203 QPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG 267
                             :..|| ..|:...:.|              :|.|:.:    :||.:..
Frog   227 -----------------SGQDG-RPVLTTVKGG--------------AGNGLEI----MLDIQQD 255

  Fly   268 EYYC------SSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSISRD 326
            ||..      .:|...|.||..|:..|.|.::|.|...|.|::|....:..|...:|:      .
Frog   256 EYLPIWGDTEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPS------P 314

  Fly   327 GRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC--------IPFDHPLIYSNAS------ 377
            ...|.| :|....|:.:|:...|..:|...::.:.|.|        .||..|..|...:
Frog   315 WGACRF-SELGSDFFPVYSISACRIDCETRYIVENCGCKMVHMPGDAPFCTPEQYKECAEPALDL 378

  Fly   378 ICSMGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNYLASGFSFPLASNNFQLANALVESFNKS 442
            :......:||              |...|..:.:  |...|....|..::    |..|.:.||||
Frog   379 LAEKDGGNCV--------------CTIPCNVTRY--NKELSMVKIPSKTS----AKYLEKKFNKS 423

  Fly   443 --YLSKNIAVINVYFRESVYYG--NTKNAY--VGLTEFLSNVGGVMGLFMGFSVISLAEI---LY 498
              |:..||.|::|:| |::.|.  ..:.||  .||   |.::||.||||:|.|::::.|:   :|
Frog   424 EKYILDNILVLDVFF-EALNYETIEQRKAYEVAGL---LGDIGGQMGLFIGASILTILELFDYIY 484

  Fly   499 FLILKPLAEL 508
            .||.:.|.:|
Frog   485 ELIKEKLLDL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	124/519 (24%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	124/519 (24%)
asic2	XP_004918663.1	ASC	49..497	CDD:383197	128/526 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010