DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and asic4

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_031749131.1	Gene:	asic4 / 100486325	XenbaseID:	XB-GENE-940165	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	540	Identity:	120/540 - (22%)
Similarity:	198/540 - (36%)	Gaps:	157/540 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSAGTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLI 69
            |:||               |.|..|.:.::||||:.:..:|....::|.:..:|:.:|:..::.:
Frog    35 PAAG---------------RDLAAFASTSTLHGLRHIFQTGRLGIKQSLWALAFLASLLFFLYQV 84

  Fly    70 SNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSL--------VANY-------REG 119
            :...:.:...|.:..:..:...  ::.||||||||:|:.:.|.        :||.       |||
Frog    85 AKCALYYLEHPHVTAVDEEVMG--EMIFPAITICNINRFRHSALTDPDIYHLANLTGLPPKDREG 147

  Fly   120 SNESALLKLLCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCS 184
            ..:|.|:                        .::..:.:.|:........||..|.||.  .:||
Frog   148 HRDSDLM------------------------YDDPDMLDIVNRTGHQLAEMLKSCNFSG--DSCS 186

  Fly   185 -QLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPAT 248
             |.|..:.|..|.|..||                                       ..|.:|..
Frog   187 AQNFSVVFTRYGKCYTFN---------------------------------------ADKKHPKV 212

  Fly   249 ASGTGITLGFTAVLDAEMGEY--YCSSTN----GPGFKVYFHNPIEVPKVKEAGLISAIGYETNY 307
            :...|:..|...:||.:..||  ....||    ..|.:|..|:..|.|.:.:.|...:.|::|..
Frog   213 SRQGGMGNGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQDEPPYIHQMGFGVSPGFQTFV 277

  Fly   308 RIEMVRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYT----RLNCENECLAAFLYDTCSCIPFD 368
            ..:..|...:|......|..    ...|:.|..|..|:    ||.||.|.:..    .|:|....
Frog   278 SCQEQRMTYLPQPWGNCRSS----IPGEEFLSGYSTYSISACRLQCEKEAVIR----KCACRMVH 334

  Fly   369 HPLIYSNASICS--------------MGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNYLASG 419
            .|   .|.:|||              :.|||              .||  .|...| :|...:..
Frog   335 MP---GNETICSPVMYMCADHILDNMVEDTS--------------EKC--SCPTPC-NLTRYSKE 379

  Fly   420 FSFPLASNNFQLANALVESFNK--SYLSKNIAVINVYFRESVYYG--NTKNAYVGLTEFLSNVGG 480
            .|.....|... |..|...:||  :|:.:|..|::::| |::.|.  ..|.|| .|...|.::||
Frog   380 ISMVRIPNKGS-ARYLARKYNKNETYIRENFLVLDIFF-EALNYETIEQKKAY-DLPSLLGDIGG 441

  Fly   481 VMGLFMGFSVISLAEILYFL 500
            .||||:|.|.:::.|||.::
Frog   442 QMGLFIGASFLTILEILDYM 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	115/514 (22%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	115/513 (22%)
asic4	XP_031749131.1	ASC	39..514	CDD:413546	117/521 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5830
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I4647
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48391
Panther	1	1.100	-	-	O	PTHR11690
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160