DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10344 and ZDHHC1

DIOPT Version :9

Sequence 1:	NP_611671.1	Gene:	CG10344 / 37565	FlyBaseID:	FBgn0034729	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_037436.1	Gene:	ZDHHC1 / 29800	HGNCID:	17916	Length:	485	Species:	Homo sapiens

Alignment Length:	282	Identity:	71/282 - (25%)
Similarity:	115/282 - (40%)	Gaps:	58/282 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RIRSN-----PMPSRMVDILCFLIIAVFLPVVFMFEIVV-VLPAFHEPGGFFHTFTFLMAMF--- 57
            |.|.|     |.|.::|..|.:|..|     |..|.|:| :||....|.|    :..:.|:|
Human    38 RSRRNGWSWPPHPLQIVAWLLYLFFA-----VIGFGILVPLLPHHWVPAG----YACMGAIFAGH 93

  Fly    58 LVFNIKGNMIACMMIDTSVNVKKVEPPSDQLNWRE---------CGECQKLAPPRSWHCKACKVC 113
            ||.::  ..::....|.:|..|....|....|..:         |..|......||.||.||..|
Human    94 LVVHL--TAVSIDPADANVRDKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSARSKHCSACNKC 156

  Fly   114 ILKRDHHCIYTGCCIGLRNHRFFMGFIFYLFVGSVYALVYNSIYMWVIHGHIYSNWVTVLKLACP 178
            :...||||.:...|:|.||:|.|:..:....:| |..||..:.|::|      ..:|..::|...
Human   157 VCGFDHHCKWLNNCVGERNYRLFLHSVASALLG-VLLLVLVATYVFV------EFFVNPMRLRTN 214

  Fly   179 MLHLVTGSFWTNMYLVF--------YSLNILALA-----YGVL-------LLAYHVPIVLRGGVS 223
            . |.......|:::.||        .:..|||||     .|:|       ||.:|:.::.....:
Human   215 R-HFEVLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTT 278

  Fly   224 ADRTKESKEKYD-RGVYQNLRS 244
            .:...:.:...: :||::.|.|
Human   279 YEYIVQHRPPQEAKGVHRELES 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10344	NP_611671.1	zf-DHHC	93..220	CDD:279823	41/146 (28%)
ZDHHC1	NP_037436.1	Mediates interaction with STING1. /evidence=ECO:0000269\|PubMed:25299331	1..271		67/251 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		1/2 (50%)
		zf-DHHC	129..284	CDD:307600	41/162 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810