DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10344 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_611671.1	Gene:	CG10344 / 37565	FlyBaseID:	FBgn0034729	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_659564.3	Gene:	Zdhhc2 / 246326	RGDID:	628681	Length:	366	Species:	Rattus norvegicus

Alignment Length:	193	Identity:	52/193 - (26%)
Similarity:	78/193 - (40%)	Gaps:	55/193 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 RECGECQKLAPPRSWHCKACKVCILKRDHHCIYTGCCIGLRNHRFFMGFIFYLFVGSVYALVYNS 155
            |.|..|:.:.|.|..||..|..||||.||||.:...|:|..|::||:.|:       .|:|:|
  Rat   126 RYCDRCRLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFL-------AYSLLY-- 181

  Fly   156 IYMWVIHGHIYSNWVTVLKLACPMLHLVTGSFWTN-----------MYLVF----YSLNILALAY 205
                            .|.:|...|.... .||||           |:|.|    :|:::.:
  Rat   182 ----------------CLFIAATDLQYFI-RFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSS--- 226

  Fly   206 GVLLLAYHVPIVLRGGVSAD-------RTKESKEKYDRGVYQNLRSVFGNRMHLAWLSPLIRS 261
               |..||..:|.:...:.:       |....|..:..|..:|:|.|||:.... ||.|:..|
  Rat   227 ---LFGYHCWLVSKNKSTLEAFRNPVFRHGTDKNGFSLGFSKNMRQVFGDEKKY-WLLPIFSS 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10344	NP_611671.1	zf-DHHC	93..220	CDD:279823	39/141 (28%)
Zdhhc2	NP_659564.3	DHHC	19..301	CDD:418707	52/193 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..366
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000250\|UniProtKB:P59267	298..366
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000250\|UniProtKB:P59267	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000250\|UniProtKB:P59267	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810