Protein Alignment rad50 and rad50

DIOPT Version :9

• Sequence 1: NP_001246461.1
• Gene: rad50 / 37564
• FlyBaseID: FBgn0034728
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_012815225.1
• Gene: rad50 / 779556
• XenbaseID: XB-GENE-1007569
• Length: 1312
• Species: Xenopus tropicalis
• Alignment Length: 1353
• Identity: 408/1353 - (30%)
• Similarity: 729/1353 - (53%)
• Gaps: 101/1353 - (7%)

  Fly     1 MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGK 65
            ||.||.:||||:||||....:.|.|:|.:|:||::|.||.||||::|||||..||:.|||| :||
 Frog     1 MSKIEKMSIQGVRSFGIEDKNKQVIQFFTPLTLLVGPNGAGKTTIIECLKYITTGDFPPGS-KGK 64

  Fly    66 SFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKKRNKMSFETMDSTINFLTGAGQSKR 130
            :||||||:....:|.|||::|::|..|..|::.|:|..::|.....|:|::..|.      :.|.
 Frog    65 TFVHDPKVAHETDVRAQIRLQLKDVNGELVAVQRSMICTQKGKSTEFKTLEGVIT------RMKH 123

  Fly   131 EKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKA 195
            .::.|||.:..::|..:...:|||.|::|||:|||||||:|||.|.::||.|||.||..|.|.||
 Frog   124 GEKVSLSTKCAEMDKEMISALGVSSAVLNNVIFCHQEDSNWPLSEGRQLKVKFDEIFSATRYIKA 188

  Fly   196 LDKIIKLRKEAMEELKIKEANIKHVAYLKQEME-VKTL--NLQKAQRKCDAIKAQCSECEEEMKP 257
            |:.:.|:|....:.::..:..||   ||||..| .:.:  |||..:::....|......|.:::|
 Frog   189 LETLRKVRLNQAQNVREYQVEIK---YLKQNKEKAREIQDNLQSKEKQLAVSKENVKSIESQLEP 250

  Fly   258 IEARLVEI-RN------VEFEIGKYQAQKVEMDTKHKNCKDQISTLTLKIKKPFRGTLDELDQEI 315
            ::.||.:| ||      ::.||...:::|..|:..:::.::       |::|.|:||.:||....
 Frog   251 LKDRLADIQRNLTKVMRLDNEIKALESRKRTMEKDNQDLEE-------KMEKVFQGTDEELSDMY 308

  Fly   316 SNFDQRMLEMRQKRTEVEGDLSQ-IKRSSVAEQEK--LGTQDRKHCLAKQRHQSELACRAQLLKR 377
            .|..:.:.|..:|..:.:.|:.: .|.|....:||  |..|..:..|...:||..:..|..|:|
 Frog   309 QNHQRTVREKERKLNDHQRDMDRACKESQRLNREKGELLVQQGRLQLEADQHQQYIKTRDSLIK- 372

  Fly   378 VKEFCRELHIPIDCDLVEQPEKMGEVLRDIEAMIITK----HCEITEIVEQNEKADRSRQVKIDE 438
                  .|...::.|..|:.........:.:.::..:    .....:|:.:..:.:..:|.:|||
 Frog   373 ------SLAAQLELDGFERTPFNQRQTSNFQMLVKERQEKDEAHANQILREFSEREAMKQRQIDE 431

  Fly   439 LRIELTKSEQSVTAQEKQRESSKRESETLGVEIKKIETSMQDLKKLEKEINEVNELYESATKNID 503
            :|.:.|..|:::..:...:.....:.:.:..|::::|.|...|::|::|:.:.....|:..|:.:
 Frog   432 IRDKKTGLERTIELKSSTQSKKHTDLKNVKYELQQLEGSSDRLQELDEELQKTERELENVEKSCN 496

  Fly   504 QQAIKDAIARKKASIAENQIQFKKLDEQLTFLGSMAKLVAECSLKQKELDKKNQEVHRVRSRHSD 568
            .:|::..:|:.::..::.....:|||:::..|.:......:..:.:|:...|::::.:::|||:|
 Frog   497 LEALRGEVAQLQSQKSDLDRNVRKLDQEMEQLNTHTMTRTQMDMLKKDKADKDEQIRKIKSRHND 561

  Fly   569 HFGKLFKE-PITCNYRRSMQVVYEKLRREIQELNEKANTQKLKEQSYEIKRKNLISDISRMEKEL 632
            ....|... |   |.::....:|.| |:::.:..||......:..:.|..:.:|.:::.|.|::.
 Frog   562 ELSSLIGYFP---NKKQLEDWLYSK-RKDVNQTREKLARFTKELVAAEQNKNHLSNELRRKEEQS 622

  Fly   633 KDSEELIYQKCRSTPYDDLLERSKTTISKLQFDHGALKSSEALYKKYIQKMDEE--PSCPLCHHN 695
            ...||.::..|.|..:|..|.|.:..|.|.......|..:.|:|.::|..:.||  |.||:|...
 Frog   623 TSFEEKVFDVCGSQDFDSDLSRLQDDIEKTSKQRAMLAGATAVYTQFITTLTEENQPCCPVCQRI 687

  Fly   696 MTSD-EACDLTSELTDEIQKLPDNITRAEKALKAEQIKYENLLQLKPTILKVKELKD-SLPQKKE 758
            ..|: |..|:.:::..:::.:||.:..||..||.::.:.:.:::|||....:.:||: .:|:.:.
 Frog   688 FPSEAELQDVINDMQSKLRLVPDKLKAAEGELKRKEKRKDEMMELKPMRQMLADLKEKEVPEIRN 752

  Fly   759 EL----KKVEELLGDSVSEYETLIA-LIGEPTHNMELANSMMGDMSLLDE---ALKDSAR----- 810
            :|    ::::.|..| |.|.||||| .:.|.    |.|.:.:.|:||::.   .|:|..|
 Frog   753 KLVAINREIQRLKND-VEEQETLIATFVSEE----ESAKACLQDISLMERYQMELRDVERKIAQY 812

  Fly   811 LTKDLDLQKGQLPASYDSSVSMDDLQAEKSKVSKELETERKELESAQNAVQQQMDALNRLREKKN 875
            .||   ||      ..|.:.::..:..||.:....|:....::|..:..:|.|.:.:.:|:...|
 Frog   813 ATK---LQ------GVDLNRTVQQVNQEKQEKQHSLDNVSGKIELLRKRIQDQQEQVQQLKSTVN 868

  Fly   876 SLKDRQIHLREGLQSLPQLKERLEKLNSFLTTVASEISELKAKIQPLKLNLRAAIEEKERLKKSE 940
            .|...::|:...||...||:|:..:|.:.|..::.||.|.|.::.||:..|:...:||:.|.:.:
 Frog   869 ELTAEKLHISSNLQRRQQLEEQNVELTTELQCLSREIKEAKEQVFPLESTLQKFQQEKQELLQRK 933

  Fly   941 SEKLAQLNSKYNSYKSTDHDIQRLNKEAEDY---AKLDLRNEIK-KLDEIIM------ASKDKLR 995
            .....:...|.|..|.....|...:|:.|.|   .|.|.:.:.: :|.|:|.      ..|:|:.
 Frog   934 ELSYREAQEKVNDIKEKVKKINLFSKDIEKYIQDGKEDFKEQKECELQELIARLNECEKQKEKIN 998

  Fly   996 KLATEISLKTDELETIKTECSNQQTVERDLKDNRELKQLEDKEAKLRESCQVLDKQLGNLDFHSV 1060
            :          |:..|:.:...|:..||.|:||..|::..::..::.|..|.|.|::|.:....:
 Frog   999 R----------EMVNIRQDIDTQKIQERCLQDNLTLRKRIEELKRVEEERQQLLKEMGQMKVMQM 1053

  Fly  1061 SKEKVNLTKQRDKATVRKGELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCI 1125
            ..|...|..:.:.........||:......::.:.::|:.||::|::.:.:|.....:..|.|.|
 Frog  1054 KNEHQELENKSETLKTNHSLALGRQKGFEDEILRFKKELREPQYKDAEEKYRDKMIVMRTTELAI 1118

  Fly  1126 EDLGQYRLALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYN 1190
            :||..|...|:.|:::|||.|||.||::||:.||..|||.||:||::::|.....::||:|:|||
 Frog  1119 KDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADEGVSAADKRRTYN 1183

  Fly  1191 YRVVQSKNYSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEA 1255
            ||||..|..:.::|||||||||:|||||||||||||||..|||:||||||||||||.||.||..|
 Frog  1184 YRVVMIKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHA 1248

  Fly  1256 LNCIVEERQSQSNFMLIIITHDENFVSSLGK---ITSYHRVFRN-EECKSVIR 1304
            |..|::.|..|.||.|::|||||:||..||:   :..::|:.:| ::|..::|
 Frog  1249 LVEIIKSRSRQRNFQLVVITHDEDFVELLGRSEYVEHFYRIKKNIDQCSEIMR 1301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rad50	NP_001246461.1	rad50	2..1295	CDD:129694	404/1340 (30%)
		ABC_Rad50	4..>173	CDD:213207	76/168 (45%)
		Rad50_zn_hook	669..716	CDD:282302	13/49 (27%)
		ABC_Rad50	<1203..1302	CDD:213207	63/102 (62%)
rad50	XP_012815225.1	rad50	2..1312	CDD:129694	407/1352 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3185
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38092
Inparanoid	1	1.050	636	1.000	Inparanoid score	I815
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126777at33208
OrthoFinder	1	1.000	-	-		FOG0004656
OrthoInspector	1	1.000	-	-		oto104018
Panther	1	1.100	-	-	LDO	PTHR18867
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3270
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070