DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rad50 and Rad50

DIOPT Version :9

Sequence 1:	NP_001246461.1	Gene:	rad50 / 37564	FlyBaseID:	FBgn0034728	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_071582.2	Gene:	Rad50 / 64012	RGDID:	621542	Length:	1312	Species:	Rattus norvegicus

Alignment Length:	1373	Identity:	409/1373 - (29%)
Similarity:	729/1373 - (53%)	Gaps:	141/1373 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGK 65
            ||.||.:||.|:||||....|.|.|.|.||:|:::|.||.||||::|||||..||:.|||: :|.
  Rat     1 MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGT-KGN 64

  Fly    66 SFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKKRNKMSFETMDSTINFLTGAGQSKR 130
            :||||||:....:|.|||::|.||..|..|.:.|:|..|:|..|..|:|::..|.      :.|.
  Rat    65 TFVHDPKVAQETDVRAQIRLQFRDVNGEMVLVQRSMLCSQKSKKTEFKTLEGVIT------RIKH 123

  Fly   131 EKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKA 195
            .::.|||.:..:||..:...:||||:::|||:|||||||:|||.|.|.||:|||.||..|.|.||
  Rat   124 GEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKA 188

  Fly   196 LDKIIKLR-------KEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAIKAQCSECEE 253
            ||.:.::|       ||...|||....|.:....::.::..|...|..::   :.:||.    |.
  Rat   189 LDTLRQVRQTQGQKVKECQTELKYLRQNKEKACEIRDQITSKEAQLASSR---EIVKAY----EN 246

  Fly   254 EMKPIEARLVEIRNVEFEIGKYQAQKVEMDTKHKNCKDQISTLTLKIKKPFRGTLDELDQEISNF 318
            |::|::.||.||.:...:|.:...:...:|::.|..:...|.|..|::|.|:||.::|:....|.
  Rat   247 ELEPLKNRLKEIEHNLSKIMRLDNEIKALDSRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNH 311

  Fly   319 DQRMLEMRQKRTEVEGDLSQIKRSSVAEQEKLGTQDRKHCLAKQ--------RHQSELACRAQLL 375
            .:.:.|..::..:.:.:|.::     :::.:|..|:|...|.:|        |||..:..|..|:
  Rat   312 QRTVREKERRLVDCQRELEKL-----SKEARLLNQERAELLVEQGRLQLQADRHQEHIRARDSLI 371

  Fly   376 KRVKEFCRELHIPID---------------CDLVEQPEK-----MGEVLRDIEAMIITKHCEITE 420
            :.:     ..|:.:|               .:||.:.::     ..::|.|:......|..::.|
  Rat   372 QSL-----AAHLELDGFERGPFSERQIKNFHELVRERQEREAKTASQLLSDLTDKEALKQRQMDE 431

  Fly   421 IVEQNEKADRSRQVKIDELRIELTKSEQSVTAQEKQRESSKRESETLGV--EIKKIETSMQDLKK 483
            :  :::|:...|.:   ||:.|:.               :|:::|...|  |::::|.|...:.:
  Rat   432 M--RDKKSGLGRMI---ELKTEIL---------------TKKQTELRNVRNELQQLEGSSDRILE 476

  Fly   484 LEKEINEVNELYESATKNIDQQAIKDAIARKKASIAENQIQFKKLDEQLTFLGSMAKLVAECSLK 548
            |::|:.:.......|.||...:.:|..|...::..|:.....:|||:::..|........:..:.
  Rat   477 LDQELTKAERELSKAEKNSSIETLKAEILNLQSEKADLDRNLRKLDQEMEQLNHHTTTRTQMEML 541

  Fly   549 QKELDKKNQEVHRVRSRHSDHFGKLFKEPITCNYRRSMQVVYEKLRREIQELNE-KANTQKLKEQ 612
            .|:...|::::.:::|||||....|.      .|..:.:.:.:.|..:.:|:|: :....||.::
  Rat   542 TKDKTDKDEQIRKIKSRHSDELTSLL------GYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE 600

  Fly   613 --SYEIKRKNLISDISRMEKELKDSEELIYQKCRSTPYDDLLERSKTTISKLQFDHGALKSSEAL 675
              |.|..:.::.:::.:.|::|...|:.::..|.|..::..|:|.|..|.|.......|..:.|:
  Rat   601 LASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDFESDLDRLKEDIEKSSKQRAMLAGATAV 665

  Fly   676 YKKYI-QKMDEEPS-CPLCHH-NMTSDEACDLTSELTDEIQKLPDNITRAEKALKAEQIKYENLL 737
            |.::| |..||..| ||:|.. ..|..|..::.|:|..:::..||.:...|..||.::.:.:.:|
  Rat   666 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEML 730

  Fly   738 QLKPTILKVKELKD-SLPQKKEELKKVE---ELLGDSVSEYETLIALIGEPTHNMELANSMMGDM 798
            .|.|....:.:||: .:|:.:..|:.|.   :.|.:.:.|.||   |:|......|.|...:.|:
  Rat   731 GLVPMRQSIIDLKEKEIPELRNRLQSVNRDIQRLKNDIEEQET---LLGTVMPEEESAKVCLTDV 792

  Fly   799 SLLDEALKDSARLTKDLDLQKGQLPA---SYDSSVSMDDLQAEKSKVSKELETERKELESAQNAV 860
            ::::....:    .||::.:..|..|   ..|...::..:..||.:...:|:|...::|..:..:
  Rat   793 TIMERFQME----LKDVERKIAQQAAKLQGVDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLI 853

  Fly   861 QQQMDALNRLREKKNSLKDRQIHLREGLQSLPQLKERLEKLNSFLTTVASEISELKAKIQPLKLN 925
            |.|.:.:..|:.|.|.||..::.:...||...|::|:..:|::.:.::..||.:.|.:|.||::.
  Rat   854 QDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQTVELSTEVQSLNREIKDAKEQINPLEIA 918

  Fly   926 LRAAIEEKERL--KKSESEKLAQLNSKYNSYKSTDHDIQRLNKEAEDYAKLDLRNEIKK-----L 983
            |....:|||.|  :|:.|.|:||  .|.|..|....:|....|:.|:|.: |.:::.||     |
  Rat   919 LEKLQQEKEELIHRKNTSNKMAQ--DKINDIKEKVKNIHGYMKDIENYIQ-DGKDDYKKQKETEL 980

  Fly   984 DEIIM------ASKDKLRKLATEISLKTDELETIKTECSNQQTVERDLKDNRELKQLEDKEAKLR 1042
            :|:::      ..|:|:.|          |:.|::.:...|:..||.|:||..|::..::..::.
  Rat   981 NEVVIQLNECDKHKEKINK----------EMGTMRQDIDTQKIQERWLQDNLTLRKRREELKEVE 1035

  Fly  1043 ESCQVLDKQLGNLDFHSVSKEKVNLTKQRDKATVRKGE--LLGQLGEIHSQVNKLQREIDEPRFK 1105
            |..:...|::|.:....:..|...|.:..|  |:::..  .||:......::...::|:.||:|:
  Rat  1036 EERKQHLKEMGQMQVLQMKNEHQKLEENID--TIKRNHSLALGRQKGYEEEILHFKKELREPQFR 1098

  Fly  1106 ESLKNFRKANYEIEVTRLCIEDLGQYRLALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYI 1170
            ::.:.:|:....:..|.|..:||..|...|:.|:::|||.|||.||::||:.||..|||.||:||
  Rat  1099 DAEEKYREMMIVMRTTELVNKDLDIYYKTLDHAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYI 1163

  Fly  1171 QVKTDEVSSDASADRRKTYNYRVVQSKNYSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVL 1235
            ::::|...:.:::|:|:.||||||..|..:.::|||||||||:|||||||||||||||..|||:|
  Rat  1164 EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIL 1228

  Fly  1236 ALDEPTTNLDRANINSLCEALNCIVEERQSQSNFMLIIITHDENFVSSLGK---ITSYHRVFRN- 1296
            |||||||||||.||.||..||..|::.|..|.||.|::|||||:||..||:   :..::||.:|
  Rat  1229 ALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRVKKNI 1293

  Fly  1297 EECKSVIR 1304
            ::|..:::
  Rat  1294 DQCSEIVK 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad50	NP_001246461.1	rad50	2..1295	CDD:129694	406/1360 (30%)
		ABC_Rad50	4..>173	CDD:213207	78/168 (46%)
		Rad50_zn_hook	669..716	CDD:282302	15/49 (31%)
		ABC_Rad50	<1203..1302	CDD:213207	64/102 (63%)
Rad50	NP_071582.2	rad50	2..1312	CDD:129694	408/1372 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341352
Domainoid	1	1.000	191	1.000	Domainoid score	I3161
eggNOG	1	0.900	-	-		E1_COG0419
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38092
Inparanoid	1	1.050	608	1.000	Inparanoid score	I893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126777at33208
OrthoFinder	1	1.000	-	-		FOG0004656
OrthoInspector	1	1.000	-	-		oto97335
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18867
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3270
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900