Protein Alignment rad50 and rad50

DIOPT Version :10

• Sequence 1: NP_726199.3
• Gene: rad50 / 37564
• FlyBaseID: FBgn0034728
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: NP_001342968.1
• Gene: rad50 / 2541635
• PomBaseID: SPAC1556.01C
• Length: 1285
• Species: Schizosaccharomyces pombe
• Alignment Length: 1410
• Identity: 395/1410 - (28%)
• Similarity: 680/1410 - (48%)
• Gaps: 237/1410 - (16%)

  Fly     1 MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGK 65
            ||.|:.:||.|||||...:  .:||:|.||:|||:|:||.||||::||||||.||..||.: :|.
pombe     1 MSCIDRMSIMGIRSFDNRS--RESIQFFSPLTLIVGQNGSGKTTIIECLKYATTGILPPNT-KGG 62

  Fly    66 SFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKKRNKMSFETMDSTINFLTGAGQSKR 130
            :|:|||||.|..|||||:|:..|:....::...|::::|.|:.....:|:|..:..|      |.
pombe    63 AFIHDPKICGEKEVLAQVKLAFRNTNQVKMICTRSLQLSVKKTTRQQKTLDGQLLIL------KD 121

  Fly   131 EKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKA 195
            .::.::|.|..::|..:...:|||||:::.|:|||||:|.|||.|...||::||.||....|.||
pombe   122 NERTTISNRCAELDSQVPLSLGVSKALLDYVIFCHQEESFWPLSEPANLKKRFDEIFESLRYAKA 186

  Fly   196 LDKIIKLRKEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAIKAQCSECEEEMKPIEA 260
            ||:|..|:::...::|:.:|.:.|....|:..|...|.:.::.::...|:::..|.::|
pombe   187 LDQIKGLKRDQETQVKVDQATLTHYRSDKERAEKIELRVHESLKRISCIRSKVEELDQE------ 245

  Fly   261 RLVEIRNVEFEIGK----YQAQKVEMDTKHKNCKDQISTLTLKIKKPFRGTLDELDQEI----SN 317
             :.|...::.|:.|    |:.|.:.:  :|...:..|...|:...|......||..:::    ||
pombe   246 -ITETARLQDELFKSTEEYEQQMITI--RHLESQSDIINTTINDLKSQMTITDESSEDLEKLHSN 307

  Fly   318 FDQRMLEMRQKRTEVE---GDLSQIKRSSVAEQEKLGTQDRKHCLAKQRHQSELACRAQLLKRVK 379
            |.:::.|.::....:|   .||..:.:|.....||| |.|    |.|  .|.|:....:|..:..
pombe   308 FAEKVKEEQELYKSLEKKRSDLESLLKSRRELLEKL-TGD----LGK--IQGEIESLEKLKVKKS 365

  Fly   380 EFCRELHIPIDCDLVEQPEKMGEVLRDIEAMIITKHCEITE-IVEQNEKADRSR--QVKIDELRI 441
            ....|:....:.:.:.:...|.||.:  .|.::.|:.||:. .:::.:.|.|:|  .:|..|:.:
pombe   366 TMINEIVHRYNINEINEEGIMTEVSK--YASLVNKNYEISSGKLKERQVAVRARIEGIKAHEMFL 428

  Fly   442 -----ELTKS-EQSVTAQEK-------------QRESSKRESETLGVEIKKIETSMQD------- 480
                 |:..| |:.:|.|::             |||...::.|...:.||.:....:.
pombe   429 NNRVSEINSSLEKQLTTQKELRSRFEILFPVKLQREDFTKDVEKSDLWIKSLRQEYESKNLLELL 493

  Fly   481 ------LKKLEKEINEVNELYESATK----NIDQQAIKDAIARKKASIAENQIQFKKLDEQLTFL 535
                  |..:|..::|::|:.:|..|    ....|..::....|.|.:| ||:        :|..
pombe   494 DKHQTALSSVENRLDEISEIVDSYHKYSGVRTKLQVFEENKTNKSAILA-NQL--------MTLK 549

  Fly   536 GSMAKLVAECSLKQKELDKKNQE----VHRVRSRHSDHFGKLFKEPITCNYRRSMQVVYEKLRRE 596
            .|.::::   |.:.|:.|..|:|    |..||.:..:      ||....:.|...:.:..::...
pombe   550 SSFSEVM---SYELKDDDNYNEELDKLVEDVRKKLQE------KEEAESSLRSVRERLEIRISLS 605

  Fly   597 IQELNEKANTQKLKE---QSYEIKRKNLISDISRMEKELKDSEELIYQKCRSTPYDDLLERSKTT 658
            :|.:|:....:|:|.   :||.....::||:|..:|.|                    :|.::.|
pombe   606 VQSINDLTENKKIKTKTLKSYSGTFASMISEIKALESE--------------------IEENRKT 650

  Fly   659 ISKLQFDHGALKSSEALYKKYIQKMDEEPSCPLCHHNMTSDEACDLTSELTDEIQKLPDNITRAE 723
            :..|||       ....|:|.|:...::.:|.||..::..:|...........|..:|.......
pombe   651 LHSLQF-------GSTFYEKAIEICVDQHACQLCQRSLDKEEEKLFVEHCHSMIDVIPSKSAEVY 708

  Fly   724 KALKAEQIKYENLLQLKPTILKVKELKDSLPQKKEELKKVE-ELLG-----DSV-SEYETLIALI 781
            ..|:.....::||.:.||...:::.|...|.:.|.||..:: :|.|     |.: ||.:||..
pombe   709 SHLETLTKTFKNLSEAKPIFDEIELLDKRLSETKTELSDLQGDLQGLDIRKDEIQSELDTLYL-- 771

  Fly   782 GEPTHNMELANSMMGDMSLLDEALKDSARLTKDLDLQKGQLPASYDSSVSMDDLQAEKSK----- 841
              ...|:|....::.|:|.|:|.::...|.|:.|.:   :||:|. :..::|::.||:.|
pombe   772 --RRANLEKLQLLVKDISNLEEEIRTIDRETEVLRI---ELPSSI-AHHNLDEIYAEREKLLEKR 830

  Fly   842 --VSKELE-------TERKELESAQNAVQQQMDALNRLREKKNSLKDRQIHLREGLQSLPQLKER 897
              :.|::|       :.:|:::.|..|..:|...|.:|..:.|.|:..:..:.:..:.....|::
pombe   831 GYLRKQIERTKLEETSFKKKIDDAVLANNEQKLKLTKLNFQVNELEQLEKDINKSSEDCDLQKKK 895

  Fly   898 LEKLNS-------FLTTVASEISELKAKIQPLKLNLRAAIEEKERLKKSESEKLAQLNSKYNSYK 955
            |.:::|       ||..:.||..:|:|.||             |..:||.:|.|     :.|.|.
pombe   896 LLEVSSKQGSQAPFLNELESEYEKLEADIQ-------------EMAQKSRTEIL-----EANEYL 942

  Fly   956 STDHDIQRLNKEAEDYAKLDLRNEIKKLDEIIMASKDKLRKLEAEISLKTDELETIKTECSNQQT 1020
               |.:...|.|    .::|:..:.|.:.|......:::|.:.::|....|.|..::...::.:|
pombe   943 ---HQLNEWNSE----LRIDVSTKFKCIKEKKSNIGEEVRIIASKIESTDDNLRKLQERLADLRT 1000

  Fly  1021 VERDLKDNREL----KQLE---------------DKEAKLRESCQVLDKQLGNLDFHSVSKEKVN 1066
            .||:..||..|    :|||               |.....||..|:|..:.|.|:
pombe  1001 RERNASDNLRLRALMRQLEEAVTQKNYLLSQQSHDDRESFRERMQILKSKYGALN---------- 1055

  Fly  1067 LTKQRDKATVRKGELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCIEDLGQY 1131
                     ..:..|||:..::.:.:.|.:.|:: ..||::.:.||:...:.:.|....||||:|
pombe  1056 ---------AERAGLLGECKQLENSITKDKEELN-MEFKDADERFRRQLIKTKTTGKANEDLGKY 1110

  Fly  1132 RLALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYNYRVVQS 1196
            ..||:.|::|.||.||..|||::.|.|::.|.|.|||.|.::     ||:.....:||||||...
pombe  1111 AKALDVAIMQLHSMKMNEINRIVDELWKQTYCGTDIDTILIR-----SDSEGKGNRTYNYRVCMV 1170

  Fly  1197 KNYSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEALNCIVE 1261
            |..:|::|||||||||:|||.:||||||||....|||:|||||||||||..||.||.:.|:.|||
pombe  1171 KGDAELDMRGRCSAGQKVLACIIIRLALAECLGVNCGILALDEPTTNLDEENICSLAKNLSRIVE 1235

  Fly  1262 ERQSQSNFMLIIITHDENF---VSSLGKITSYHRVFRNEECKSVI 1303
            .|:.|:||.||:|||||.|   |:|....:.|:||.|:...||:|
pombe  1236 FRRKQANFQLIVITHDEQFIRLVNSDAYCSYYYRVKRDTNQKSMI 1280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rad50	NP_726199.3	rad50	2..1295	CDD:129694	390/1399 (28%)
rad50	NP_001342968.1	rad50	4..1282	CDD:129694	384/1384 (28%)