DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rad50 and RAD50

DIOPT Version :9

Sequence 1:	NP_001246461.1	Gene:	rad50 / 37564	FlyBaseID:	FBgn0034728	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_005723.2	Gene:	RAD50 / 10111	HGNCID:	9816	Length:	1312	Species:	Homo sapiens

Alignment Length:	1345	Identity:	407/1345 - (30%)
Similarity:	721/1345 - (53%)	Gaps:	85/1345 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGK 65
            ||.||.:||.|:||||....|.|.|.|.||:|:::|.||.||||::|||||..||:.|||: :|.
Human     1 MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGT-KGN 64

  Fly    66 SFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKKRNKMSFETMDSTINFLTGAGQSKR 130
            :||||||:....:|.|||::|.||..|..:::.|:|..::|..|..|:|::..|.      ::|.
Human    65 TFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVIT------RTKH 123

  Fly   131 EKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKA 195
            .::.|||.:..:||..:...:|||||::|||:|||||||:|||.|.|.||:|||.||..|.|.||
Human   124 GEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKA 188

  Fly   196 LDKIIKLRKEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAI---KAQCSECEE---- 253
            |:.:.::|:...:::|..:..:|   ||||..|       ||....|.|   :||.:..:|
Human   189 LETLRQVRQTQGQKVKEYQMELK---YLKQYKE-------KACEIRDQITSKEAQLTSSKEIVKS 243

  Fly   254 ---EMKPIEARLVEIRNVEFEIGKYQAQKVEMDTKHKNCKDQISTLTLKIKKPFRGTLDELDQEI 315
               |:.|::.||.||.:...:|.|...:...:|::.|..:...|.|..|::|.|:||.::|:...
Human   244 YENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 308

  Fly   316 SNFDQRMLEMRQKRTEVEGDLSQI-KRSSVAEQEK---LGTQDRKHCLAKQRHQSELACRAQLLK 376
            .|..:.:.|..:|..:...:|.:: |.|.:..|||   |..|.|.. |...|||..:..|..|:
Human   309 HNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQ-LQADRHQEHIRARDSLI- 371

  Fly   377 RVKEFCRELHIPIDCDLVEQPEKMGEVLRDIEAMIITKHCEITEIVEQ--NEKADRS--RQVKID 437
                  :.|...::.|..|:.......:::...::..:.....:...|  |:.|::.  :|.:||
Human   372 ------QSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQID 430

  Fly   438 ELRIELTKSEQSVTAQEKQRESSKRESETLGVEIKKIETSMQDLKKLEKEINEVNELYESATKNI 502
            |:|.:.|...:.:..:.:.....:.|.:.:..|::::|.|...:.:|::|:.:.......|.||.
Human   431 EIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNS 495

  Fly   503 DQQAIKDAIARKKASIAENQIQFKKLDEQLTFLGSMAKLVAECSLKQKELDKKNQEVHRVRSRHS 567
            :.:.:|..:...:...|:.....:|||:::..|........:..:..|:...|::::.:::||||
Human   496 NVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHS 560

  Fly   568 DHFGKLFKEPITCNYRRSMQVVYEKLRREIQELNE-KANTQKLKEQ--SYEIKRKNLISDISRME 629
            |....|.      .|..:.:.:.:.|..:.:|:|: :....||.::  |.|..:.::.:::.|.|
Human   561 DELTSLL------GYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 619

  Fly   630 KELKDSEELIYQKCRSTPYDDLLERSKTTISKLQFDHGALKSSEALYKKYI-QKMDEEPS-CPLC 692
            ::|...|:.::..|.|..::..|:|.|..|.|.......|..:.|:|.::| |..||..| ||:|
Human   620 EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVC 684

  Fly   693 HH-NMTSDEACDLTSELTDEIQKLPDNITRAEKALKAEQIKYENLLQLKPTILKVKELKD-SLPQ 755
            .. ..|..|..::.|:|..:::..||.:...|..||.::.:.:.:|.|.|....:.:||: .:|:
Human   685 QRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPE 749

  Fly   756 KKEELKKVE---ELLGDSVSEYETLIALIGEPTHNMELANSMMGDMSLLDEALKDSARLTKDLDL 817
            .:.:|:.|.   :.|.:.:.|.|||:..|   ....|.|...:.|:::::....:    .||::.
Human   750 LRNKLQNVNRDIQRLKNDIEEQETLLGTI---MPEEESAKVCLTDVTIMERFQME----LKDVER 807

  Fly   818 QKGQLPA---SYDSSVSMDDLQAEKSKVSKELETERKELESAQNAVQQQMDALNRLREKKNSLKD 879
            :..|..|   ..|...::..:..||.:...:|:|...::|..:..:|.|.:.:..|:...|.||.
Human   808 KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKS 872

  Fly   880 RQIHLREGLQSLPQLKERLEKLNSFLTTVASEISELKAKIQPLKLNLRAAIEEKERL--KKSESE 942
            .::.:...||...||:|:..:|::.:.::..||.:.|.::.||:..|....:|||.|  ||:.|.
Human   873 EKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSN 937

  Fly   943 KLAQLNSKYNSYKSTDHDIQRLNKEAEDYAKLDLRNEIKKLDEI----IMASKDKLRKLATEISL 1003
            |:||  .|.|..|....:|....|:.|:|.: |.:::.||..|.    ::|...:..|...:|:
Human   938 KIAQ--DKLNDIKEKVKNIHGYMKDIENYIQ-DGKDDYKKQKETELNKVIAQLSECEKHKEKIN- 998

  Fly  1004 KTDELETIKTECSNQQTVERDLKDNRELKQLEDKEAKLRESCQVLDKQLGNLDFHSVSKEKVNLT 1068
              :::..::.:...|:..||.|:||..|::..::..::.|..:...|::|.:....:..|...|.
Human   999 --EDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLE 1061

  Fly  1069 KQRDKATVRKGELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCIEDLGQYRL 1133
            :..|.........||:......::...::|:.||:|:::.:.:|:....:..|.|..:||..|..
Human  1062 ENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYK 1126

  Fly  1134 ALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYNYRVVQSKN 1198
            .|:.|:::|||.|||.||::||:.||..|||.||:||::::|...:.:::|:|:.||||||..|.
Human  1127 TLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKG 1191

  Fly  1199 YSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEALNCIVEER 1263
            .:.::|||||||||:|||||||||||||||..|||::|||||||||||.||.||..||..|::.|
Human  1192 DTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSR 1256

  Fly  1264 QSQSNFMLIIITHDENFVSSLGK---ITSYHRVFRN-EECKSVIR 1304
            ..|.||.|::|||||:||..||:   :..::|:.:| ::|..:::
Human  1257 SQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVK 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rad50	NP_001246461.1	rad50	2..1295	CDD:129694	404/1332 (30%)
		ABC_Rad50	4..>173	CDD:213207	77/168 (46%)
		Rad50_zn_hook	669..716	CDD:282302	15/49 (31%)
		ABC_Rad50	<1203..1302	CDD:213207	62/102 (61%)
RAD50	NP_005723.2	rad50	2..1312	CDD:129694	406/1344 (30%)
		ABC_Rad50	4..>166	CDD:213207	77/168 (46%)
		Rad50_zn_hook	659..709	CDD:282302	15/49 (31%)
		ABC_Rad50	<1195..1297	CDD:213207	61/101 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147551
Domainoid	1	1.000	193	1.000	Domainoid score	I3197
eggNOG	1	0.900	-	-		E1_COG0419
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38092
Inparanoid	1	1.050	617	1.000	Inparanoid score	I898
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126777at33208
OrthoFinder	1	1.000	-	-		FOG0004656
OrthoInspector	1	1.000	-	-		oto90217
orthoMCL	1	0.900	-	-		OOG6_101667
Panther	1	1.100	-	-	LDO	PTHR18867
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1062
SonicParanoid	1	1.000	-	-		X3270
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.830