DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qkr58E-2 and Khdrbs1

DIOPT Version :9

Sequence 1:	NP_001286724.1	Gene:	qkr58E-2 / 37562	FlyBaseID:	FBgn0022985	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_569089.1	Gene:	Khdrbs1 / 117268	RGDID:	621459	Length:	443	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	115/388 - (29%)
Similarity:	173/388 - (44%)	Gaps:	121/388 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GGGSAAGTAGAGTGVVPTGVSGGTSNGEHENEHNANADGEKAQPAPAV-------------QKYM 77
            |||...|.|.|.....|..:...::.|.     :|...|  :.|.|.:             .||:
  Rat    47 GGGGPRGGARASPATQPPPLLPPSNPGP-----DATVVG--SAPTPLLPPSATAAAKMEPENKYL 104

  Fly    78 QELMTERSRMENHFPLAVKLIDEALERVQLNGRIPTRDQ--YADVYQQRTIKLSQKVHVPIKD-K 139
            .|||.|:..::..|..|::|:...:|::| .|.....|:  |.|::..:.:||.::|.:|:|. .
  Rat   105 PELMAEKDSLDPSFTHAMQLLSVEIEKIQ-KGESKKDDEENYLDLFSHKNMKLKERVLIPVKQYP 168

  Fly   140 KFNYVGKLLGPKGNSLRRLQEETQCKIVILGRFSMKDRAREEELRNSADAKYAHLNLPLHVEVST 204
            |||:|||:|||:||:::||||||..||.:||:.||:|:|:|||||...|.||||||:.|||.:..
  Rat   169 KFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEV 233

  Fly   205 IAPPAEAYARVAYALAEIRRYLTPDKHDDIRQEQYREL-----MEDPEAAKKLTLRQLQQQSNAA 264
            ..||.||||.:|:|:.|::::|.||..|||.|||:.||     :.:|...:.:::|
  Rat   234 FGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPSRGRGVSVR--------- 289

  Fly   265 ASGAGGGGGGGGGNGNGGAAGSGSNNGNGNQRSGGNYRQKFQQQSHYRHNEETVYFRSHNNAYHQ 329
                          |.|.|                                             .
  Rat   290 --------------GRGAA---------------------------------------------P 295

  Fly   330 PKPYVPAAQRGNAMHTTLPPQ-AIVRAS-----------------PPGMVVSAASFNGRNAGL 374
            |.|.||   ||..:.   ||: |:||.:                 ||..|..|.:...|.||:
  Rat   296 PPPPVP---RGRGVG---PPRGALVRGTPVRGSITRGATVTRGVPPPPTVRGAPTPRARTAGI 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr58E-2	NP_001286724.1	SF1_like-KH	129..244	CDD:239088	63/120 (53%)
Khdrbs1	NP_569089.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		12/54 (22%)
		Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q07666	100..260		72/160 (45%)
		Qua1	102..153	CDD:406639	15/51 (29%)
		KH-I	152..257	CDD:412160	55/104 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..317		16/110 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345		4/18 (22%)
		Interaction with HNRNPA1. /evidence=ECO:0000250\|UniProtKB:Q07666	351..443		1/2 (50%)
		Sam68-YY	366..415	CDD:406871
		Interaction with ZBTB7A. /evidence=ECO:0000250\|UniProtKB:Q07666	400..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8931
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850