DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qkr58E-2 and KHDRBS1

DIOPT Version :9

Sequence 1:	NP_001286724.1	Gene:	qkr58E-2 / 37562	FlyBaseID:	FBgn0022985	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_006550.1	Gene:	KHDRBS1 / 10657	HGNCID:	18116	Length:	443	Species:	Homo sapiens

Alignment Length:	406	Identity:	118/406 - (29%)
Similarity:	175/406 - (43%)	Gaps:	131/406 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GGGSAAGTAGAGTGVVPTGVSGGTSNGEHENEHNANADGEKAQPAPA---------------VQK 75
            |||.:.|.|.|.....|..:...::.|         .|.....|||.               ..|
Human    47 GGGGSRGGARASPATQPPPLLPPSATG---------PDATVGGPAPTPLLPPSATASVKMEPENK 102

  Fly    76 YMQELMTERSRMENHFPLAVKLIDEALERVQL-NGRIPTRDQYADVYQQRTIKLSQKVHVPIKD- 138
            |:.|||.|:..::..|..|::|:...:|::|. :.:....:.|.|::..:.:||.::|.:|:|.
Human   103 YLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQY 167

  Fly   139 KKFNYVGKLLGPKGNSLRRLQEETQCKIVILGRFSMKDRAREEELRNSADAKYAHLNLPLHVEVS 203
            .|||:|||:|||:||:::||||||..||.:||:.||:|:|:|||||...|.||||||:.|||.:.
Human   168 PKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIE 232

  Fly   204 TIAPPAEAYARVAYALAEIRRYLTPDKHDDIRQEQYREL-----MEDPEAAKKLTLRQLQQQSNA 263
            ...||.||||.:|:|:.|::::|.||..|||.|||:.||     :.:|...:.:.:|
Human   233 VFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPSRGRGVPVR-------- 289

  Fly   264 AASGAGGGGGGGGGNGNGGAAGSGSNNGNGNQRSGGNYRQKFQQQSHYRHNEETVYFRSHNNAYH 328
                           |.|.|
Human   290 ---------------GRGAA--------------------------------------------- 294

  Fly   329 QPKPYVPAAQRGNAMHTTLPPQ-AIVRASPPGMVVSAASFNGRNAGLGNAGGGGIMANSIVATTG 392
            .|.|.||   ||..:.   ||: |:||.:|    |..|...|                   ||..
Human   295 PPPPPVP---RGRGVG---PPRGALVRGTP----VRGAITRG-------------------ATVT 330

  Fly   393 GGIGGAVPPNMRYRPA 408
            .|:  ..||.:|..||
Human   331 RGV--PPPPTVRGAPA 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr58E-2	NP_001286724.1	SF1_like-KH	129..244	CDD:239088	63/120 (53%)
KHDRBS1	NP_006550.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		12/57 (21%)
		Involved in homodimerization. /evidence=ECO:0000305\|PubMed:26758068	100..260		70/159 (44%)
		Qua1	102..153	CDD:406639	13/50 (26%)
		KH-I_KHDRBS1	152..257	CDD:411896	55/104 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..316		15/109 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..346		8/20 (40%)
		Interaction with HNRNPA1. /evidence=ECO:0000269\|PubMed:17371836	351..443
		Sam68-YY	366..415	CDD:406871
		Interaction with ZBTB7A. /evidence=ECO:0000269\|PubMed:24514149	400..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155067
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	167	1.000	Inparanoid score	I4169
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8456
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.860