DRSC/TRiP Functional Genomics Resources

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Protein Alignment qkr58E-2 and KHDRBS1

DIOPT Version :10

Sequence 1:NP_523810.2 Gene:qkr58E-2 / 37562 FlyBaseID:FBgn0022985 Length:416 Species:Drosophila melanogaster
Sequence 2:NP_006550.1 Gene:KHDRBS1 / 10657 HGNCID:18116 Length:443 Species:Homo sapiens


Alignment Length:406 Identity:118/406 - (29%)
Similarity:175/406 - (43%) Gaps:131/406 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 GGGSAAGTAGAGTGVVPTGVSGGTSNGEHENEHNANADGEKAQPAPA---------------VQK 75
            |||.:.|.|.|.....|..:...::.|         .|.....|||.               ..|
Human    47 GGGGSRGGARASPATQPPPLLPPSATG---------PDATVGGPAPTPLLPPSATASVKMEPENK 102

  Fly    76 YMQELMTERSRMENHFPLAVKLIDEALERVQL-NGRIPTRDQYADVYQQRTIKLSQKVHVPIKD- 138
            |:.|||.|:..::..|..|::|:...:|::|. :.:....:.|.|::..:.:||.::|.:|:|. 
Human   103 YLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQY 167

  Fly   139 KKFNYVGKLLGPKGNSLRRLQEETQCKIVILGRFSMKDRAREEELRNSADAKYAHLNLPLHVEVS 203
            .|||:|||:|||:||:::||||||..||.:||:.||:|:|:|||||...|.||||||:.|||.:.
Human   168 PKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIE 232

  Fly   204 TIAPPAEAYARVAYALAEIRRYLTPDKHDDIRQEQYREL-----MEDPEAAKKLTLRQLQQQSNA 263
            ...||.||||.:|:|:.|::::|.||..|||.|||:.||     :.:|...:.:.:|        
Human   233 VFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPSRGRGVPVR-------- 289

  Fly   264 AASGAGGGGGGGGGNGNGGAAGSGSNNGNGNQRSGGNYRQKFQQQSHYRHNEETVYFRSHNNAYH 328
                           |.|.|                                             
Human   290 ---------------GRGAA--------------------------------------------- 294

  Fly   329 QPKPYVPAAQRGNAMHTTLPPQ-AIVRASPPGMVVSAASFNGRNAGLGNAGGGGIMANSIVATTG 392
            .|.|.||   ||..:.   ||: |:||.:|    |..|...|                   ||..
Human   295 PPPPPVP---RGRGVG---PPRGALVRGTP----VRGAITRG-------------------ATVT 330

  Fly   393 GGIGGAVPPNMRYRPA 408
            .|:  ..||.:|..||
Human   331 RGV--PPPPTVRGAPA 344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
qkr58E-2NP_523810.2 KH-I_KHDRBS 124..224 CDD:411812 54/100 (54%)
KHDRBS1NP_006550.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96 12/57 (21%)
Involved in homodimerization. /evidence=ECO:0000305|PubMed:26758068 100..260 70/159 (44%)
Qua1 102..153 CDD:465079 13/50 (26%)
KH-I_KHDRBS1 152..257 CDD:411896 55/104 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..316 15/109 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..346 8/20 (40%)
Interaction with HNRNPA1. /evidence=ECO:0000269|PubMed:17371836 351..443
Sam68-YY 366..415 CDD:465182
Interaction with ZBTB7A. /evidence=ECO:0000269|PubMed:24514149 400..420
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 411..443
Blue background indicates that the domain is not in the aligned region.

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