DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr58E-1 and QKI

DIOPT Version :9

Sequence 1:	NP_523809.2	Gene:	qkr58E-1 / 37561	FlyBaseID:	FBgn0022986	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_006766.1	Gene:	QKI / 9444	HGNCID:	21100	Length:	341	Species:	Homo sapiens

Alignment Length:	320	Identity:	88/320 - (27%)
Similarity:	145/320 - (45%)	Gaps:	83/320 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DTPQLNEKTNAYLQECLLEKKTLEK--------KHIITKRLLDDEVEKILVSGRIPKPEIY---A 103
            :|.:..:.|..||.:.:.:||.:..        .|:  :||||:|:.::       :.::|   .
Human     6 ETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHL--ERLLDEEISRV-------RKDMYNDTL 61

  Fly   104 NVYSEK----------PI-RVAQKVLFPIKEYPKFNFVGKILGPKGNTLRQLQEETMCKMVVMGR 157
            |..:||          || ::.:|:..|:||||.|||||:||||:|.|.:||:.||.||::|.|:
Human    62 NGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGK 126

  Fly   158 NSMRDHGKEEELRSSGNPKYAHLSRDLHVEISTVAPPAEAYHRISYALGEIRKFMIP--DANDDI 220
            .||||..|||:.|  |.|.:.||:.||||.|:.......|..::..|:.|::|.::|  :..|.:
Human   127 GSMRDKKKEEQNR--GKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSL 189

  Fly   221 RLEQLREMDGKERMYKKSHHYSKSYGDHGAYSS-------------------RTPPPASSKPKVY 266
            :..||.|:......|:.::..|.:.....|.::                   |||.||.  |.:.
Human   190 KKMQLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAG--PTIM 252

  Fly   267 SILEK--------------ARYVMDDPNYGIVKTHRSRDHELYDHHGEYDRYATPPPQTS 312
            .::.:              |..|...|..|::.|             .|:...|..|.||
Human   253 PLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYT-------------PYEYPYTLAPATS 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr58E-1	NP_523809.2	KH-I	109..210	CDD:412160	48/111 (43%)
QKI	NP_006766.1	STAR_dimer	10..66	CDD:406848	13/64 (20%)
		Qua1 domain, involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q17339	11..82		17/79 (22%)
		KH-I_Hqk	81..183	CDD:411893	47/103 (46%)
		Qua2 domain, involved in RNA binding. /evidence=ECO:0000269\|PubMed:23630077	182..213		6/30 (20%)
		PHA03247	<211..314	CDD:223021	18/104 (17%)
		SH3-binding	276..279		0/2 (0%)
		Quaking_NLS	312..341	CDD:406855
		Nuclear localization signal. /evidence=ECO:0000250	324..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1833
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.690