DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr58E-1 and khdrbs2

DIOPT Version :9

Sequence 1:	NP_523809.2	Gene:	qkr58E-1 / 37561	FlyBaseID:	FBgn0022986	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001070758.1	Gene:	khdrbs2 / 768147	ZFINID:	ZDB-GENE-061013-497	Length:	346	Species:	Danio rerio

Alignment Length:	382	Identity:	133/382 - (34%)
Similarity:	189/382 - (49%)	Gaps:	94/382 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 YLQECLLEKKTLEKKHIITKRLLDDEVEK-----ILVSGRIPKPEIYANVYSEKPIRVAQKVLFP 120
            ||.|.:.||::|:...:...|||.:|:||     :...|.:.|   |.::.|.|.|:::::||.|
Zfish     6 YLPELVAEKESLDASFVHAMRLLAEEIEKFEGDELRKDGEVKK---YLDIISNKNIKLSERVLIP 67

  Fly   121 IKEYPKFNFVGKILGPKGNTLRQLQEETMCKMVVMGRNSMRDHGKEEELRSSGNPKYAHLSRDLH 185
            :::|||||||||:|||:||::::|||||..||.::|:.||||.|||||||.||..||||||.|||
Zfish    68 VQQYPKFNFVGKLLGPRGNSMKRLQEETGAKMSILGKGSMRDKGKEEELRKSGEAKYAHLSNDLH 132

  Fly   186 VEISTVAPPAEAYHRISYALGEIRKFMIPDANDDIRLEQLRE---MDGKE-------------RM 234
            |.|...|||.|||.|:|:||.||:||::||.||:||.|||||   ::|.:             |:
Zfish   133 VLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSDDPSRGRSARGRGLRL 197

  Fly   235 YKKSHHYSK------------SYGDHGAYSSRT--PPPAS--SKPKVYSILEKARYVMDDPNY-- 281
            ...:....:            :....|..||||  |.||.  |.|       :.|.....|.|
Zfish   198 TSTASPRGRGSAAPPAPPGRGAAAPRGTVSSRTSVPTPARGVSAP-------RTRGTAGTPGYRA 255

  Fly   282 -GIVKTHRSRDHELYDHHGEYDRYATPPPQTSKHSTHHAQYDSSSYERDYRREYHPHSSSSSYAA 345
             .:..||::     |:.:|..|.|             ..:||..||| .|...|...|.|.|...
Zfish   256 PSLQATHKT-----YEDYGYDDGY-------------DGEYDDQSYE-SYDDNYSNQSKSVSEYY 301

  Fly   346 AYPAKPSNGRSSSSYRPTTSGSGSHSSAHYETGSRSRESVR----------YRSAPY 392
            .|    .:|.:..:|           :.:.|....||.:::          ||..||
Zfish   302 EY----GHGNNDENY-----------NNYEEDWISSRPNLKAPASRLTRGGYRDHPY 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr58E-1	NP_523809.2	KH-I	109..210	CDD:412160	63/100 (63%)
khdrbs2	NP_001070758.1	Qua1	6..57	CDD:292891	16/53 (30%)
		SF1_like-KH	61..180	CDD:239088	74/118 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..292		28/142 (20%)
		Sam68-YY	<281..>306	CDD:293176	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3866
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26159
orthoMCL	1	0.900	-	-		OOG6_110429
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.760