DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr58E-1 and Khdrbs3

DIOPT Version :9

Sequence 1:	NP_523809.2	Gene:	qkr58E-1 / 37561	FlyBaseID:	FBgn0022986	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_034288.2	Gene:	Khdrbs3 / 13992	MGIID:	1313312	Length:	346	Species:	Mus musculus

Alignment Length:	378	Identity:	130/378 - (34%)
Similarity:	187/378 - (49%)	Gaps:	74/378 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LNEKTNAYLQECLLEKKTLEKKHIITKRLLDDEVEKILVSGRIPKPEIYANVYSEKPIRVAQKVL 118
            :.||   ||.|.:.||.:|:.......||::.|:|| ...|...:.|.|.:|...|.:::.||||
Mouse     1 MEEK---YLPELMAEKDSLDPSFTHALRLVNREIEK-FQKGEGKEEEKYIDVVINKNMKLGQKVL 61

  Fly   119 FPIKEYPKFNFVGKILGPKGNTLRQLQEETMCKMVVMGRNSMRDHGKEEELRSSGNPKYAHLSRD 183
            .|:|::||||||||:|||:||:|::|||||:.||.::|:.||||..||||||.||..||.||:.|
Mouse    62 IPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDD 126

  Fly   184 LHVEISTVAPPAEAYHRISYALGEIRKFMIPDANDDIRLEQLREMD---------------GKER 233
            |||.|...|||||||.|:.:||.||:||:|||.||:||..||:|:.               ||..
Mouse   127 LHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKST 191

  Fly   234 MYKKSHHYSKSYGDHGAYSSR---------TPPP---ASSKPKVYSILEKARYVMDDPNYGIVKT 286
            :..:...........|..::|         ||.|   .|::..|    .:.|.::.....|:..|
Mouse   192 LRTRGVTTPAITRGRGGVTARPVAVGVPRGTPTPRGVLSTRGPV----SRGRGLLTPRARGVPPT 252

  Fly   287 HRSRDHELYDHHGEYDRYATPPPQTSKHSTHHAQYDSSSYERDYRREYHPHSSSSSYAAAY--PA 349
                            .|..|||..::.:  :.:||   |:..|...| ...|..||..:|  ||
Mouse   253 ----------------GYRPPPPPPTQET--YGEYD---YDDGYGTAY-DEQSYDSYDNSYSTPA 295

  Fly   350 KPS-------NGRSSSSYRPTTSGSGSH---SSAHYETGSRSRESVRYRSAPY 392
            :.:       :|.|..:|    ...|..   :|.|....:|:.:.| ||..||
Mouse   296 QSAADYYDYGHGLSEDAY----DSYGQEEWTNSRHKAPSARTAKGV-YRDQPY 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr58E-1	NP_523809.2	KH-I	109..210	CDD:412160	62/100 (62%)
Khdrbs3	NP_034288.2	Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:O75525	1..160		84/162 (52%)
		Qua1	5..53	CDD:292891	15/48 (31%)
		SF1_like-KH	58..177	CDD:239088	73/118 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..266		13/75 (17%)
		Sam68-YY	266..320	CDD:293176	15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..346		9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4780
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3911
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8696
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.860