DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr58E-3 and QKI

DIOPT Version :9

Sequence 1:	NP_001246460.1	Gene:	qkr58E-3 / 37559	FlyBaseID:	FBgn0022984	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_006766.1	Gene:	QKI / 9444	HGNCID:	21100	Length:	341	Species:	Homo sapiens

Alignment Length:	325	Identity:	89/325 - (27%)
Similarity:	141/325 - (43%)	Gaps:	72/325 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METPSEFTEKQPPTHDHQPRLNEVAQKFLADLDEERQRLSADFPLCAL------LIDEAVDRVYC 59
            |||    .||..||.|           :|..|..:::.:|:....|.:      |:||.:.||
Human     5 MET----KEKPKPTPD-----------YLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRV-- 52

  Fly    60 TGRIPGKEFYADVYKQKPMK--------------ITQKVFVPVKQYPKFNFTGKILGPKGNSLRR 110
                 .|:.|.|.......|              :.:|::||||:||.|||.|:||||:|.:.::
Human    53 -----RKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQ 112

  Fly   111 LQEETQCKIAIKGRSSIRDRNKEEQLRSTGDPRYAHLQKDLFLEVSTVATPAECYARIAYALAEI 175
            |:.||.|||.::|:.|:||:.||||.|  |.|.:.||.:||.:.::..........::..|:.|:
Human   113 LEAETGCKIMVRGKGSMRDKKKEEQNR--GKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEV 175

  Fly   176 RKYLIP--DKNDEVSHEQLRELMEMD-PESAKNIHGPNLEAYRSVFDKKFGGNSNGAPKYIN--- 234
            :|.|:|  :..|.:...||.||..:: .....||..|.| |:      .....:..||:.|.
Human   176 KKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPAL-AF------SLAATAQAAPRIITGPA 233

  Fly   235 --LIKRAAENP-PEVDDVEEVAYEYEHRMPPKRPPTGYEYSKPRPSIIPTNAAA------YKRPY 290
              |...|...| |....:..:..:.:..:.|...|      .|..:|:|....|      |:.||
Human   234 PVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTP------HPTAAIVPPGPEAGLIYTPYEYPY 292

Fly 291 290
Human 293 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr58E-3	NP_001246460.1	SF1_like-KH	81..200	CDD:239088	47/121 (39%)
QKI	NP_006766.1	STAR_dimer	10..66	CDD:406848	16/73 (22%)
		Qua1 domain, involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q17339	11..82		16/88 (18%)
		KH-I_Hqk	81..183	CDD:411893	42/103 (41%)
		Qua2 domain, involved in RNA binding. /evidence=ECO:0000269\|PubMed:23630077	182..213		7/30 (23%)
		PHA03247	<211..314	CDD:223021	19/95 (20%)
		SH3-binding	276..279		1/2 (50%)
		Quaking_NLS	312..341	CDD:406855
		Nuclear localization signal. /evidence=ECO:0000250	324..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740