DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qkr58E-3 and KHDRBS1

DIOPT Version :9

Sequence 1:	NP_001246460.1	Gene:	qkr58E-3 / 37559	FlyBaseID:	FBgn0022984	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_006550.1	Gene:	KHDRBS1 / 10657	HGNCID:	18116	Length:	443	Species:	Homo sapiens

Alignment Length:	309	Identity:	99/309 - (32%)
Similarity:	148/309 - (47%)	Gaps:	62/309 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPTHDHQPRLNEVAQKFLADLDEERQRLSADFPLCALLIDEAVDRVY-CTGRIPGKEFYADVYKQ 75
            ||:.....:: |...|:|.:|..|:..|...|.....|:...::::. ...:...:|.|.|::..
Human    88 PPSATASVKM-EPENKYLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSH 151

  Fly    76 KPMKITQKVFVPVKQYPKFNFTGKILGPKGNSLRRLQEETQCKIAIKGRSSIRDRNKEEQLRSTG 140
            |.||:.::|.:||||||||||.||||||:||:::||||||..||::.|:.|:||:.|||:||..|
Human   152 KNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGG 216

  Fly   141 DPRYAHLQKDLFLEVSTVATPAECYARIAYALAEIRKYLIPDKNDEVSHEQLRELMEMD--PESA 203
            ||:||||..||.:.:.....|.|.||.:|:|:.|::|:|:||..|::..||..||..::  ||.:
Human   217 DPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPS 281

  Fly   204 KNIHGPNLEAYRSVFDKKFGGNSNGAPKYINLIKRAAENPPEVDDVEEVAYEYEHRMPPKRPPTG 268
            :                     ..|.|    :..|.|..||                ||  .|.|
Human   282 R---------------------GRGVP----VRGRGAAPPP----------------PP--VPRG 303

  Fly   269 YEYSKPRPSIIP--------TNAAAYKRPYPTDMKRMREPPIKSYKPNP 309
            .....||.:::.        |..|...|..|       .||.....|.|
Human   304 RGVGPPRGALVRGTPVRGAITRGATVTRGVP-------PPPTVRGAPAP 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qkr58E-3	NP_001246460.1	SF1_like-KH	81..200	CDD:239088	61/120 (51%)
KHDRBS1	NP_006550.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		2/7 (29%)
		Involved in homodimerization. /evidence=ECO:0000305\|PubMed:26758068	100..260		69/159 (43%)
		Qua1	102..153	CDD:406639	10/50 (20%)
		KH-I_KHDRBS1	152..257	CDD:411896	57/104 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..316		12/78 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..346		7/26 (27%)
		Interaction with HNRNPA1. /evidence=ECO:0000269\|PubMed:17371836	351..443
		Sam68-YY	366..415	CDD:406871
		Interaction with ZBTB7A. /evidence=ECO:0000269\|PubMed:24514149	400..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8456
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810