DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment babos and DSCAM

DIOPT Version :9

Sequence 1:	NP_001286719.1	Gene:	babos / 37557	FlyBaseID:	FBgn0034724	Length:	196	Species:	Drosophila melanogaster
Sequence 2:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens

Alignment Length:	161	Identity:	36/161 - (22%)
Similarity:	59/161 - (36%)	Gaps:	31/161 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DQMQADDDFDYGGEDQ-----SAPSPQTKSPNPVASEKINKTLSVTGIRGEDVVLKCDV-GSNLH 90
            |::.|.|......||.     ||.|.:..||                  .|.|.|.|:| |:.|.
Human   390 DKLSAQDYVQVVLEDGTPKIISAFSEKVVSP------------------AEPVSLMCNVKGTPLP 436

  Fly    91 SSDVVVLWYFGDN-VISNGKNLVQPNFKLDANYDLTILKASPQV--AGSYLCKVLPSGSVVNTKV 152
            :    :.|...|: ::..|.:.:......:.|....:..:|.||  .|.|.|....|..||..:.
Human   437 T----ITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQA 497

  Fly   153 TIAEHSLDAIAPESSTSAAGSASSFLGCTVL 183
            .|......:|.|..:.:|.....:::.|.|:
Human   498 RINVRGPASIRPMKNITAIAGRDTYIHCRVI 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
babos	NP_001286719.1	ig	70..154	CDD:278476	20/87 (23%)
babos	NP_001286719.1	IG_like	70..154	CDD:214653	20/87 (23%)
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254
		Ig_3	407..488	CDD:316449	22/102 (22%)
		IGc2	518..575	CDD:197706	2/11 (18%)
		I-set	596..686	CDD:333254
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:325142
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900