DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13506 and MYOT

DIOPT Version :9

Sequence 1:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_006781.1	Gene:	MYOT / 9499	HGNCID:	12399	Length:	498	Species:	Homo sapiens

Alignment Length:	366	Identity:	71/366 - (19%)
Similarity:	122/366 - (33%)	Gaps:	84/366 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PPYFDVTDLRVEAKPGDDVI--LNCDARNFQLSNAVVWYKNRIIIAN-----------GQNPISQ 120
            ||..:.:....:.|....:|  ..|..:.|..|:.:   .:.|.:::           |.|| .|
Human    23 PPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTL---SSHITMSSSAFPASPQQHAGSNP-GQ 83

  Fly   121 RVQCMLNNS--ILLRNVSPEDSDDYYCEILP-------------QRVRQHTALRVGARLSILCDD 170
            ||....|.|  ..|.::.| ...||....:|             |.:....:....|:......|
Human    84 RVTTTYNQSPASFLSSILP-SQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPD 147

  Fly   171 RDITDRSQTFRQGDHHKLECRTYLPDNATIKWSFNDLNGQPSSVDNQNGVIILDNVDEKNAGDYQ 235
            .:|....:...|....||:|:..|..|...:.::.:...: ..:..||...:....|:..|.|.|
Human   148 HEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKMAR-RLLGPQNAAAVFQAQDDSGAQDSQ 211

  Fly   236 CLADDGSRHPPHGTVHIDVQYSPIVSTHRHNVNTEKGATAELY------------------CNYR 282
                  ..:..|..:.:........||.|.:||.:.....:.|                  |...
Human   212 ------QHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMD 270

  Fly   283 AKPIGR-----SYFIKDGKTLQLSDKYSLKDSVHNDHNRTTLIVREVTDSDLGEYLCQVENAIGS 342
            .|..|.     |::: :|:|:|..|.:.:..|....|   :||...|..||.|.|.|..:|..|.
Human   271 FKVSGLPAPDVSWYL-NGRTVQSDDLHKMIVSEKGLH---SLIFEVVRASDAGAYACVAKNRAGE 331

  Fly   343 NEVKVHVS-------------YNPETPQFEDMTVEGNKVTL 370
            ....|.:.             |.|::.:    .:||:.|.|
Human   332 ATFTVQLDVLAKEHKRAPMFIYKPQSKK----VLEGDSVKL 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	18/81 (22%)
		IGc2	83..146	CDD:197706	17/77 (22%)
		IG_like	176..254	CDD:214653	13/77 (17%)
		Ig	176..239	CDD:299845	12/62 (19%)
		I-set	258..349	CDD:254352	27/113 (24%)
		Ig	275..348	CDD:143165	21/95 (22%)
MYOT	NP_006781.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..151		16/88 (18%)
		Necessary for interaction with ACTN1	79..150		15/72 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..241		10/44 (23%)
		Necessary for interaction with ACTA1. /evidence=ECO:0000269\|PubMed:12499399	215..498		34/162 (21%)
		Necessary for interaction with FLNC	215..493		34/162 (21%)
		Ig	249..333	CDD:299845	20/87 (23%)
		I-set	250..340	CDD:254352	21/93 (23%)
		I-set	349..440	CDD:254352	6/24 (25%)
		Ig_Myotilin_C	366..440	CDD:143300	2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45080
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100