DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13506 and Kirrel3

DIOPT Version :9

Sequence 1:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus

Alignment Length:	534	Identity:	111/534 - (20%)
Similarity:	192/534 - (35%)	Gaps:	158/534 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GDDVILNCDARNFQLSNAVVWYKNRIIIANGQNPISQRVQCMLNNSIL----LRNVSPEDSDD-- 142
            |..|.|.|....:  ...|:|.|:.:.:..|::..|.....::.|.:.    |:.:..|..||
Mouse    62 GQPVTLLCAIPEY--DGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAV 124

  Fly   143 YYCEILPQRVRQHTALRVGARLSILC--DDRDITDRSQ-TFRQGDHHKLECRTYLPDN----ATI 200
            |.|:.:...:|...     |||::|.  ||..|..... :.|.||...|.|..   ||    |:|
Mouse   125 YECQAIQAAIRSRP-----ARLTVLVPPDDPIILGGPVISLRAGDPLNLTCHA---DNAKPAASI 181

  Fly   201 KW--SFNDLNGQPSSV----DNQNGVII----LDNVDEKNAGDYQCLADDGSRHPPHG---TVHI 252
            .|  ....:||...|.    |.:...|:    :...|.:|.....|.|.  ::..|.|   :|.|
Mouse   182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRAT--NKAIPGGKETSVTI 244

  Fly   253 DVQYSPIVSTHRHNVNTEKGATAE-----LYCNYRAKP-------IGRSYFIKD----------- 294
            |:|:.|:|     |::.|.....|     .:|:.:|.|       ..|.:.||:
Mouse   245 DIQHPPLV-----NLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVD 304

  Fly   295 ---------------------GKTLQL-------SDKYSLKDSVHND------------------ 313
                                 .:|:.:       |:..||...:.:|
Mouse   305 YTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWM 369

  Fly   314 --------HNRTTLIVREVTDSDLGEYLCQ-VENAIGSNEVKVHVSYNPETPQFEDMT-----VE 364
                    .|..||.::.|...|.|:|:|: |...:|:.|.:|.::.|  .|.....|     :.
Mouse   370 KRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN--GPPIISSTQTQHALH 432

  Fly   365 GNKVTLHWLVRSHQ-------LLSEAMLDYQLTGSYTWSTVQVLETHRHNNTDNIWKITHQLELS 422
            |.|..:...:||..       ...|.:|:...:|.||..||         ||:.  .:...|.:|
Mouse   433 GEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETV---------NTEE--GVISTLTIS 486

  Fly   423 RGVWHARVKT-KNTKGWSHFSND-HVFEIPED-SEVDKDEEVELPPDEIVQAGIMPMSKGAASSM 484
             .:..|..:| .|...|:.|.:| .:..:.|. ||:.....:|  .:.:..|.|:.::.||..:.
Mouse   487 -NIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLE--AESVPMAVIIGVAVGAGVAF 548

  Fly   485 QRLNVGVILLAALL 498
                  ::|:|.::
Mouse   549 ------LVLMATIV 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	15/67 (22%)
		IGc2	83..146	CDD:197706	15/67 (22%)
		IG_like	176..254	CDD:214653	23/95 (24%)
		Ig	176..239	CDD:299845	18/77 (23%)
		I-set	258..349	CDD:254352	28/168 (17%)
		Ig	275..348	CDD:143165	23/150 (15%)
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	20/87 (23%)
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353	3/6 (50%)
		Ig strand C	78..82	CDD:409353	2/3 (67%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	0/3 (0%)
		Ig strand E	104..116	CDD:409353	2/11 (18%)
		Ig strand G	132..143	CDD:409353	4/15 (27%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	25/101 (25%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	1/3 (33%)
		Ig strand E	210..214	CDD:409416	0/3 (0%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	7/66 (11%)
		Ig strand B	267..274	CDD:409353	1/6 (17%)
		Ig strand C	279..286	CDD:409353	0/6 (0%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	0/5 (0%)
		Ig strand G	321..334	CDD:409353	1/12 (8%)
		Ig	335..416	CDD:416386	16/80 (20%)
		Ig strand A'	343..347	CDD:409353	2/3 (67%)
		Ig strand B	350..360	CDD:409353	1/9 (11%)
		Ig strand C	365..371	CDD:409353	0/5 (0%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	23/108 (21%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	0/3 (0%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	1/4 (25%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900