DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13506 and IL1R1

DIOPT Version :9

Sequence 1:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_000868.1	Gene:	IL1R1 / 3554	HGNCID:	5993	Length:	569	Species:	Homo sapiens

Alignment Length:	315	Identity:	70/315 - (22%)
Similarity:	124/315 - (39%)	Gaps:	66/315 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VEAKPGDDVILNCDARNFQLSNAVVWYKNRIIIANGQNPISQRVQCMLN---NSILLRNVSPEDS 140
            ::.:|       |.....:....:.|||:     :.:.|:|......::   ..:.......|||
Human    39 IDVRP-------CPLNPNEHKGTITWYKD-----DSKTPVSTEQASRIHQHKEKLWFVPAKVEDS 91

  Fly   141 DDYYCEILPQRVRQHT-ALRVGARLSILCDDRDITDRSQT-FRQ-----GDHHKLEC-------- 190
            ..|||.     ||..: .||:......:.::.::...:|. |:|     || ..|.|
Human    92 GHYYCV-----VRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGD-GGLVCPYMEFFKN 150

  Fly   191 -RTYLPDNATIKWSFNDLNGQPSSVDN--QNGV---IILDNVDEKNAGDYQCLADD---GSRHPP 246
             ...||   .::| :.|.  :|..:||  .:||   :|:.||.||:.|:|.|.|..   |.::|.
Human   151 ENNELP---KLQW-YKDC--KPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPI 209

  Fly   247 HGTVHIDV--QYSP----IVSTHRHNVNTEKGATAELYCNYRAKPIGRSYFIKDGKTLQLSDKYS 305
            ...:....  :..|    |||.....:..:.|:..:|.||...:....:|:..:|..:...|...
Human   210 TRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVL 274

  Fly   306 LKD--SVHNDHN--RTTLI-VREVTDSDLGEY----LCQVENAIGSNEVKVHVSY 351
            .:|  ||.|..|  |:||| |..:::.:...|    .|..:|..|.:...:.:.|
Human   275 GEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIY 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	12/69 (17%)
		IGc2	83..146	CDD:197706	12/65 (18%)
		IG_like	176..254	CDD:214653	27/100 (27%)
		Ig	176..239	CDD:299845	24/82 (29%)
		I-set	258..349	CDD:254352	25/103 (24%)
		Ig	275..348	CDD:143165	20/81 (25%)
IL1R1	NP_000868.1	Ig1_IL1R_like	24..113	CDD:319308	17/90 (19%)
		Ig2_IL1R_like	128..219	CDD:319309	26/97 (27%)
		IG	234..328	CDD:214652	21/93 (23%)
		TIR	384..540	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000