DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13506 and Igsf9

DIOPT Version :9

Sequence 1:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	107/493 - (21%)
Similarity:	170/493 - (34%)	Gaps:	134/493 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 HAEQEAPPYFDVT-DLRVEAKPGDDVILNCDARNFQLSNA---VVWYKNRIIIANGQNPISQRVQ 123
            |....:||.|..| .|.:|.|..:.|.|.|.|    |.:.   |.|......:..||..:..|
  Rat   129 HLTVNSPPQFQETPPLVLEVKELEAVTLRCVA----LGSPQPYVTWKFRGQDLGKGQGQVQVR-- 187

  Fly   124 CMLNNSILLRNVSPEDSDDYYCEILPQR--VRQHTALRV-GARLSILCDDRDITDRSQTFRQGDH 185
               |.::.:|.|....:.||.|:.....  |...|.|.| |..:.::..:.:..:.||..
  Rat   188 ---NGTLWIRRVERGSAGDYTCQASSTEGSVTHTTQLLVLGPPVIVVPPNNNTVNASQDV----- 244

  Fly   186 HKLECRT-YLPDNATIKWSFNDLN-GQPSSVDNQ-----NGVIILDNVDEKNAGDYQCLADDGSR 243
             .|.||. ..|.|.|..|..:.:| ...|.:.::     :|.:.|......:||.|.|:..:|..
  Rat   245 -SLACRAEAYPANLTYSWFQDRINVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFP 308

  Fly   244 HPPHGTVHIDVQYSPIVSTHRHNVNTEKGATAELYCNYRAKPIGRSYFI---KDGKTLQLSDKY- 304
            |||..:.::.|.|...|:..........|....:.|..||.|  ...|:   |||:.||| ||:
  Rat   309 HPPSASAYLTVLYPAQVTVMPPETPLPIGMRGVIRCPVRANP--PLLFVTWTKDGQALQL-DKFP 370

  Fly   305 --SLKDSVHNDHNRTTLIVREVTDSDLGEYLCQVENAIGSNEVKVHVSYNPET-------PQFED 360
              ||..       ..:|::....:..||||.|...|::|:      ...:|.|       |.|.|
  Rat   371 GWSLGP-------EGSLVIALGNEDALGEYSCTPYNSLGT------AGSSPVTRVLLKAPPAFID 422

  Fly   361 MTVE------GNKVTL------------HWLVRSHQLLSEAMLDYQLTGSYTWSTVQVLETHRHN 407
            ...|      |..:.:            .|......|..:|.:|                   .|
  Rat   423 QPKEEYFQEVGRDLLIPCSARGDPPPIVSWAKVGRGLQGQAQVD-------------------SN 468

  Fly   408 NTDNIWKITHQLELSRGVWHARVK------TKNTKGWSHFSNDHVFEIPEDSEVDKDEEVELPPD 466
            |:..:..:|.:   :.|.|....:      |.:|..:...::.||
  Rat   469 NSLILRPLTKE---AHGRWECSARNAVAHVTISTNVYVLGTSPHV-------------------- 510

  Fly   467 EIVQAGIMPMSKGAASS---------MQRLNVGVILLA 495
             :....::|:.|||..|         :||.:|....||
  Rat   511 -VTNVSVVPLPKGANVSWEPGFDGGYLQRFSVWYTPLA 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	17/69 (25%)
		IGc2	83..146	CDD:197706	15/65 (23%)
		IG_like	176..254	CDD:214653	21/84 (25%)
		Ig	176..239	CDD:299845	17/69 (25%)
		I-set	258..349	CDD:254352	25/96 (26%)
		Ig	275..348	CDD:143165	23/78 (29%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652
		Ig strand A	136..139	CDD:409353	1/2 (50%)
		IG_like	143..223	CDD:214653	22/88 (25%)
		Ig strand A'	145..148	CDD:409353	0/2 (0%)
		Ig strand B	154..161	CDD:409353	4/10 (40%)
		Ig strand C	167..172	CDD:409353	2/4 (50%)
		Ig strand C'	175..177	CDD:409353	0/1 (0%)
		Ig strand D	183..187	CDD:409353	0/3 (0%)
		Ig strand E	189..193	CDD:409353	0/3 (0%)
		Ig strand F	202..210	CDD:409353	3/7 (43%)
		Ig strand G	213..223	CDD:409353	3/9 (33%)
		Ig_3	226..305	CDD:404760	17/84 (20%)
		putative Ig strand A	226..230	CDD:409353	0/3 (0%)
		putative Ig strand A'	235..239	CDD:409353	0/3 (0%)
		putative Ig strand B	241..251	CDD:409353	5/15 (33%)
		putative Ig strand C'	267..270	CDD:409353	1/2 (50%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	2/5 (40%)
		putative Ig strand F	297..305	CDD:409353	3/7 (43%)
		putative Ig strand G	310..319	CDD:409353	2/8 (25%)
		Ig	322..407	CDD:416386	25/100 (25%)
		Ig strand A'	324..328	CDD:409353	1/3 (33%)
		Ig strand B	333..347	CDD:409353	2/13 (15%)
		Ig strand C	353..359	CDD:409353	1/5 (20%)
		Ig strand C'	362..364	CDD:409353	0/1 (0%)
		Ig strand D	371..374	CDD:409353	0/2 (0%)
		Ig strand E	378..382	CDD:409353	1/3 (33%)
		Ig strand F	391..399	CDD:409353	4/7 (57%)
		Ig	418..503	CDD:416386	16/106 (15%)
		Ig strand A	418..421	CDD:409353	1/2 (50%)
		Ig strand A'	427..430	CDD:409353	0/2 (0%)
		Ig strand B	436..443	CDD:409353	0/6 (0%)
		Ig strand C	449..454	CDD:409353	1/4 (25%)
		Ig strand C'	457..459	CDD:409353	0/1 (0%)
		Ig strand D	462..466	CDD:409353	1/3 (33%)
		Ig strand E	469..473	CDD:409353	1/3 (33%)
		Ig strand F	482..490	CDD:409353	2/7 (29%)
		Ig strand G	493..503	CDD:409353	2/9 (22%)
		FN3	508..599	CDD:238020	12/61 (20%)
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900