DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13506 and Il18rap

DIOPT Version :9

Sequence 1:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_034683.1	Gene:	Il18rap / 16174	MGIID:	1338888	Length:	614	Species:	Mus musculus

Alignment Length:	511	Identity:	98/511 - (19%)
Similarity:	177/511 - (34%)	Gaps:	144/511 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DTQIIDVTK-NHAEQEAPPYFDVTDLRVEAKPGDDVILNCDARNFQLSNAVVWYKNRIIIANGQN 116
            |.|.:...| :||.|.:|.....      .||       |......||: |.||..    ....:
Mouse    47 DLQELQEQKFSHASQLSPTQSPA------HKP-------CSGSQKDLSD-VQWYMQ----PRSGS 93

  Fly   117 PISQ--RVQCMLNNSILLRNVSPEDSD--DYYC------------------EILPQR-------V 152
            |:.:  |....:.:..:|..::|:.:.  .|.|                  |:.|||       .
Mouse    94 PLEEISRNSPHMQSEGMLHILAPQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTA 158

  Fly   153 RQHTALRVGARLSILCDDRDITDRSQTFRQGDHHKLECRTY-----LPDNATIKWSFNDLNGQPS 212
            :....|.:|:..||.|.....        |.|....|...|     ||::..     |.:.....
Mouse   159 QDEQVLLLGSTGSIHCPSLSC--------QSDVQSPEMTWYKDGRLLPEHKK-----NPIEMADI 210

  Fly   213 SVDNQNGVIILDNVDEKNAGDYQCLADDGSRHPPHGTVHIDVQYSP-IVSTHRHNVNTEKGATAE 276
            .|.|| |:.:.|.....|...:...|....|     |:..|:...| |:......::.|.|....
Mouse   211 YVFNQ-GLYVCDYTQSDNVSSWTVRAVVKVR-----TIGKDINVKPEILDPITDTLDVELGKPLT 269

  Fly   277 LYCNYR------AKPIGRSYFIKDGKTLQLS--DKYSLKDSVHNDHNRTTLIVREVTDSDLG-EY 332
            |.|..:      :||:.:.|..:..:..::|  ::..::.:..|:....|:.:||||..||. ::
Mouse   270 LPCRVQFGFQRLSKPVIKWYVKESTQEWEMSVFEEKRIQSTFKNEVIERTIFLREVTQRDLSRKF 334

  Fly   333 LCQVENAIGSNEVKVHVSYNPETPQFEDMTVEGNKVTLHWLVRSHQLLSEAMLDYQLTGSYT--- 394
            :|..:|:||:....:.:....|                  :|..:.||..|::   |.|...
Mouse   335 VCFAQNSIGNTTRTIRLRKKEE------------------VVFVYILLGTALM---LVGVLVAAA 378

  Fly   395 ---WSTVQ-VLETHRHNNTDNIWKITHQLELSRGVWHARVKTKNTKGWSHFSNDHVF-----EIP 450
               |..:: ||....:.|.|.  .:..:.|....|.::...:..|......|.:|:.     |:.
Mouse   379 FLYWYWIEVVLLCRTYKNKDE--TLGDKKEFDAFVSYSNWSSPETDAVGSLSEEHLALNLFPEVL 441

  Fly   451 EDSE------VDKDEEVELPP-----DEIVQAGIMPMSKGAASSMQRLNVGVILLA 495
            ||:.      :|:|    :.|     |:||            |.:::...|:.:|:
Mouse   442 EDTYGYRLCLLDRD----VTPGGVYADDIV------------SIIKKSRRGIFILS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	14/88 (16%)
		IGc2	83..146	CDD:197706	13/84 (15%)
		IG_like	176..254	CDD:214653	16/82 (20%)
		Ig	176..239	CDD:299845	13/67 (19%)
		I-set	258..349	CDD:254352	22/100 (22%)
		Ig	275..348	CDD:143165	18/81 (22%)
Il18rap	NP_034683.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..78		6/31 (19%)
		Ig	161..243	CDD:299845	21/100 (21%)
		Ig	255..351	CDD:299845	20/95 (21%)
		IG_like	262..352	CDD:214653	20/89 (22%)
		TIR	410..558	CDD:279864	16/88 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000