Protein Alignment CG13506 and CEACAM5

DIOPT Version :10

• Sequence 1: NP_611666.2
• Gene: CG13506 / 37556
• FlyBaseID: FBgn0034723
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_004354.3
• Gene: CEACAM5 / 1048
• HGNCID: 1817
• Length: 702
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 90/395 - (22%)
• Similarity: 163/395 - (41%)
• Gaps: 60/395 - (15%)

  Fly    45 YGDDTDDDDTQIIDVTKNHAEQEAPPYFDVTDLRVEAKPGDDVILNCDARNFQLSNAV-VWYKNR 108
            :..||..:.|.:..:|   ...|.|..|..::.....:..|.|.|.|:.   ::.|.. :|:.|
Human   302 HNSDTGLNRTTVTTIT---VYAEPPKPFITSNNSNPVEDEDAVALTCEP---EIQNTTYLWWVN- 359

  Fly   109 IIIANGQNPISQRVQCMLNN-SILLRNVSPEDSDDYYCEILPQRVRQHTALRVGARLSILC--DD 170
                |...|:|.|:|...:| ::.|.:|:..|...|.|.|..:....|:...:   |::|.  ||
Human   360 ----NQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVI---LNVLYGPDD 417

  Fly   171 RDITDRSQTFRQGDHHKLECRTYLPDNATIKWSFNDLNGQPSSVDNQNGVIILDNVDEKNAGDYQ 235
            ..|:.....:|.|.:..|.|.......|...|..:      .::......:.:.|:.|||:|.|.
Human   418 PTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLID------GNIQQHTQELFISNITEKNSGLYT 476

  Fly   236 CLADD---GSRHPPHGTVHIDVQY-SPIVSTHRHNVNTEKGATAELYCNYRAKPIGRSYFIKDGK 296
            |.|::   |.......|:.:..:. .|.:|::......:|.|.| ..|...|:.....::: :|:
Human   477 CQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVA-FTCEPEAQNTTYLWWV-NGQ 539

  Fly   297 TLQLSDKYSLKDSVHNDHNRTTLIVREVTDSDLGEYLCQVENAIGSNE---VKVHVSYNPETPQF 358
            :|.:|.:..|.:.     || ||.:..||.:|...|:|.::|::.:|.   |.:.|.|.|:||..
Human   540 SLPVSPRLQLSNG-----NR-TLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPII 598

  Fly   359 ---EDMTVEGNKVTL------------HWLV----RSH-QLLSEAMLDYQLTGSYTWSTVQVLET 403
               :...:.|..:.|            .|.:    :.| |:|..|.:.....|:|. ..|..|.|
Human   599 SPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYA-CFVSNLAT 662

  Fly   404 HRHNN 408
            .|:|:
Human   663 GRNNS 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13506	NP_611666.2	Ig_3	69..146	CDD:464046	19/78 (24%)
		Ig_3	173..238	CDD:464046	14/64 (22%)
		Ig	258..349	CDD:472250	23/93 (25%)
		Ig strand B	275..279	CDD:409353	1/3 (33%)
		Ig strand C	288..292	CDD:409353	0/3 (0%)
		Ig strand E	317..321	CDD:409353	2/3 (67%)
		Ig strand F	331..336	CDD:409353	2/4 (50%)
CEACAM5	NP_004354.3	IgV_CEACAM_D1	36..140	CDD:409430
		FR1	37..55	CDD:409430
		Ig strand A	37..39	CDD:409430
		Ig strand A'	44..46	CDD:409430
		Ig strand B	49..56	CDD:409430
		CDR1	56..63	CDD:409430
		FR2	64..69	CDD:409430
		Ig strand C	64..68	CDD:409430
		CDR2	70..91	CDD:409430
		Ig strand C'	78..83	CDD:409430
		Ig strand C'	88..91	CDD:409430
		FR3	98..124	CDD:409430
		Ig strand D	98..103	CDD:409430
		Ig strand E	105..109	CDD:409430
		Ig strand F	119..124	CDD:409430
		CDR3	125..132	CDD:409430
		FR4	133..140	CDD:409430
		Ig strand G	133..139	CDD:409430
		IgI_hCEACAM_2_4_6_like	146..234	CDD:409402
		Ig strand A	146..150	CDD:409402
		Ig strand A'	153..158	CDD:409402
		Ig strand B	163..169	CDD:409402
		Ig strand C	176..181	CDD:409402
		Ig strand C'	183..186	CDD:409402
		Ig strand D	190..194	CDD:409402
		Ig strand E	197..202	CDD:409402
		Ig strand F	212..220	CDD:409402
		Ig strand G	224..233	CDD:409402
		IgC2_CEACAM5-like	243..318	CDD:409540	4/18 (22%)
		Ig strand A	243..249	CDD:409540
		Ig strand B	254..261	CDD:409540
		Ig strand C	267..273	CDD:409540
		Ig strand C'	276..281	CDD:409540
		Ig strand E	284..290	CDD:409540
		Ig strand F	293..304	CDD:409540	0/1 (0%)
		Ig strand G	307..318	CDD:409540	2/13 (15%)
		IgI_hCEACAM_2_4_6_like	324..412	CDD:409402	22/98 (22%)
		Ig strand A	324..328	CDD:409402	1/3 (33%)
		Ig strand A'	331..336	CDD:409402	0/4 (0%)
		Ig strand B	341..347	CDD:409402	3/5 (60%)
		Ig strand C	354..359	CDD:409402	1/4 (25%)
		Ig strand C'	361..364	CDD:409402	0/2 (0%)
		Ig strand D	368..372	CDD:409402	2/3 (67%)
		Ig strand E	375..380	CDD:409402	1/4 (25%)
		Ig strand F	390..398	CDD:409402	3/7 (43%)
		Ig strand G	402..411	CDD:409402	2/11 (18%)
		IgC2_CEACAM5-like	421..496	CDD:409540	16/80 (20%)
		Ig strand A	421..427	CDD:409540	0/5 (0%)
		Ig strand B	432..439	CDD:409540	2/6 (33%)
		Ig strand C	445..451	CDD:409540	2/5 (40%)
		Ig strand C'	454..459	CDD:409540	0/4 (0%)
		Ig strand E	462..468	CDD:409540	1/5 (20%)
		Ig strand F	471..482	CDD:409540	5/10 (50%)
		Ig strand G	485..496	CDD:409540	2/10 (20%)
		IgI_hCEACAM_2_4_6_like	502..590	CDD:409402	23/95 (24%)
		Ig strand A	502..506	CDD:409402	1/3 (33%)
		Ig strand A'	509..514	CDD:409402	0/4 (0%)
		Ig strand B	519..525	CDD:409402	2/6 (33%)
		Ig strand C	532..537	CDD:409402	0/5 (0%)
		Ig strand C'	539..542	CDD:409402	0/2 (0%)
		Ig strand D	546..550	CDD:409402	0/3 (0%)
		Ig strand E	553..558	CDD:409402	4/5 (80%)
		Ig strand F	568..576	CDD:409402	2/7 (29%)
		Ig strand G	580..589	CDD:409402	2/8 (25%)
IgC2_CEACAM5-like	599..674	CDD:409540	14/70 (20%)
Ig strand A	599..605	CDD:409540	0/5 (0%)
Ig strand B	610..617	CDD:409540	1/6 (17%)
Ig strand C	623..629	CDD:409540	1/5 (20%)
Ig strand C'	632..637	CDD:409540	0/4 (0%)
Ig strand E	640..646	CDD:409540	2/5 (40%)
Ig strand F	649..660	CDD:409540	3/11 (27%)
Ig strand G	663..674	CDD:409540	2/5 (40%)