DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wrapper and PAPLN

DIOPT Version :9

Sequence 1:NP_477404.1 Gene:wrapper / 37555 FlyBaseID:FBgn0025878 Length:500 Species:Drosophila melanogaster
Sequence 2:NP_001352835.1 Gene:PAPLN / 89932 HGNCID:19262 Length:1278 Species:Homo sapiens


Alignment Length:360 Identity:81/360 - (22%)
Similarity:129/360 - (35%) Gaps:107/360 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 PTTVKTYENDTVQLPCTLNT-PFRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGSLQVANVQSS 104
            |:.|:......|:|.|:.:| |.....|.:|...:...||       |:..  :|||.:..:|:.
Human   916 PSLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRH-------RLQF--DGSLIIHPLQAE 971

  Fly   105 DTGDYYC------------EMNSDSGHVVQQHAIEVQLAPQVLIEPSDLTEQ--------RIGAI 149
            |.|.|.|            ::....|.:......|:...||    |.|..:.        .:|||
Human   972 DAGTYSCGSTRPGRDSQKIQLRIIGGDMAVLSEAELSRFPQ----PRDPAQDFGQAGAAGPLGAI 1032

  Fly   150 ----------------------------FEVVCEAQGVPQPVITWRLNGN-VIQPQSNTGNRQSL 185
                                        ..:.|.|:|.|.|.|.|:.:|. |..|:.......||
Human  1033 PSSHPQPANRLRLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSL 1097

  Fly   186 ILEIKSRNQAGLIECVASNG------------VGEPAVANVYLHVLFSPEVSIPQPVVYTKLGSR 238
            ::...:....|...|||.||            :||..::.:      .|.|::|:       |..
Human  1098 VISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGL------PPTVTVPE-------GDT 1149

  Fly   239 AHLECIVEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVRNADMG 303
            |.|.|:| |..:..::|..:||||....| ..|:|...|              |::.::|..|.|
Human  1150 ARLLCVV-AGESVNIRWSRNGLPVQADGH-RVHQSPDGT--------------LLIYNLRARDEG 1198

  Fly   304 QYECRA--SNQISVKSGSVELTGRPMPCLFKINPG 336
            .|.|.|  .:|...:|..|::.. |.|.....:||
Human  1199 SYTCSAYQGSQAVSRSTEVKVVS-PAPTAQPRDPG 1232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wrapperNP_477404.1 Ig 41..124 CDD:299845 21/95 (22%)
IG_like 41..118 CDD:214653 20/89 (22%)
IG_like 145..218 CDD:214653 23/113 (20%)
Ig 147..219 CDD:299845 23/112 (21%)
I-set 224..323 CDD:254352 27/100 (27%)
IGc2 236..314 CDD:197706 23/79 (29%)
FN3 339..431 CDD:238020
PAPLNNP_001352835.1 TSP1 29..80 CDD:214559
ADAM_spacer1 183..298 CDD:310520
TSP1 308..361 CDD:214559
TSP1 369..424 CDD:214559
TSP1 424..481 CDD:214559
TSP1 488..539 CDD:214559
Kunitz_BPTI 753..805 CDD:278443
Papilin_u7 814..905 CDD:318767
Ig 914..>978 CDD:325142 19/70 (27%)
I-set 1049..1119 CDD:254352 18/69 (26%)
IG 1139..1219 CDD:214652 28/102 (27%)
PLAC 1235..1267 CDD:312271
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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