DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrapper and ush2a

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	594	Identity:	119/594 - (20%)
Similarity:	186/594 - (31%)	Gaps:	212/594 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TPHMCSVVRCLLAALILGQVQAELDFNNDLENSQKFKSIPTTVKTYENDTVQLPCTLNTPFRYVR 66
            |.:..:::.|.:|..:                    .|.||.::|.|.    .|.|:::|.
Zfish  4353 TLYSYAIIACTVAGCV--------------------TSGPTQIRTLEG----APATVDSPI---- 4389

  Fly    67 WHRDDVALVDSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIEVQLA 131
                   |.|.....|          |.|..|.:.|:.:...|..::|:|          ||...
Zfish  4390 -------LSDITSYSL----------NVSWTVPSFQNGEIVVYILKVNND----------EVYRG 4427

  Fly   132 PQVLIEPSDLTEQRIGAIFEVVC----------------EA--QGVPQPV----------ITW-- 166
            .::.::..||......:|....|                ||  .|:|.|.          :||
Zfish  4428 KRLSVQVLDLQPHVSYSIILTACTNGGCTSSSPILIQTREAPPSGMPAPTLKVTGPESVEVTWRE 4492

  Fly   167 -------------RLNGNVIQPQSNTGNRQSLIL-------EIKSRNQAGLIECVASNGVGEPAV 211
                         |.||::|...::|......:|       .|.:.|..|..       ...|||
Zfish  4493 PVHPNGVIMGYELRRNGSLIYTGTDTRYHDFTLLPSVEYSYTITANNSEGAT-------TSPPAV 4550

  Fly   212 ANVYLHVLFSPEVSIPQPVVYTKLGSRAHLECIVEAAPAA-------------------TVKWFH 257
            |..        :.|.|..|...:|.:......:|:..|.|                   .||.|
Zfish  4551 ART--------QPSAPSGVAPPRLQALGPFSVMVKWDPPARPNGVIISYSLYKRDPAENNVKRF- 4606

  Fly   258 HGLPVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVRNADMGQYECRASNQISVKSGSVEL 322
                |....||.........|....:|    |:     .||........|.||:..|:::.....
Zfish  4607 ----VFASHHSAFQSRSFSLNTLKPYY----RY-----EVRVEACSLLGCAASDWSSIQTLESPP 4658

  Fly   323 TGRPMPCL-FKINP-GTQSSTSHVLVWQ--TESLLPIMEFKLKFRQIPSNNVTRQVRTNWTELTI 383
            .|:|.|.| .:.|| |.|  |..:|.|.  ||....::.::| :|:..|:..:|.|.|
Zfish  4659 AGQPAPLLELQTNPKGLQ--TVFLLSWSPPTEPNGKLLHYEL-YRKHLSDMESRSVTT------- 4713

  Fly   384 PAQATNGLIYITTYT-LHG--LQPASLYEVSVLARNSFG-----W-------------SDNSKIV 427
                   |:|..:.| .|.  |||.:.||..|.|.||.|     |             |....:.
Zfish  4714 -------LVYSDSSTSCHDDKLQPYTAYEYQVWAVNSAGRAGSPWAQGHTGPAPPEGISSPKFLY 4771

  Fly   428 RFATGGEVEL-----PN-----YSTESELQDDFTEEDFHNEITQRSEVLSASMMFNSGSVNGRGG 482
            .::|...|::     ||     |...::.:|.:   ...:|.|...:.|.....|...||    |
Zfish  4772 IYSTSAVVDISPPTKPNGIISLYRVFAQNKDSY---QLLSEGTSHQQTLHGLRPFTVYSV----G 4829

  Fly   483 ISAFIYSLC 491
            :......||
Zfish  4830 VEVCTCFLC 4838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	17/82 (21%)
		IG_like	41..118	CDD:214653	17/76 (22%)
		IG_like	145..218	CDD:214653	22/122 (18%)
		Ig	147..219	CDD:299845	22/121 (18%)
		I-set	224..323	CDD:254352	22/117 (19%)
		IGc2	236..314	CDD:197706	17/96 (18%)
		FN3	339..431	CDD:238020	27/114 (24%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470	2/12 (17%)
		FN3	4382..4465	CDD:238020	19/113 (17%)
		FN3	4470..4553	CDD:238020	18/89 (20%)
		FN3	4555..4653	CDD:238020	22/111 (20%)
		FN3	4679..4753	CDD:238020	25/88 (28%)
		fn3	4760..4830	CDD:278470	13/76 (17%)
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900