DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrapper and paplna

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_005169942.1	Gene:	paplna / 562930	ZFINID:	ZDB-GENE-070815-4	Length:	1187	Species:	Danio rerio

Alignment Length:	353	Identity:	79/353 - (22%)
Similarity:	132/353 - (37%)	Gaps:	91/353 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KSIPTTVKTYENDTVQLPCTLNTP---FRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGSLQVA 99
            |:.|:||:......|.|||.:..|   ...|.|.||.|.:..:||.:         ..:|||.|.
Zfish   836 KTDPSTVEGLVGQRVVLPCRVTPPPSSAVLVEWRRDGVPVDPTRHEQ---------QLDGSLLVG 891

  Fly   100 NVQSSDTGDYYC---------------------EMNSDSGHVVQQHAIEVQLAPQVLIEPSDLTE 143
            .:...|:|.:.|                     :.|:....|....:...|.:.:..|:.|.|.|
Zfish   892 PITLQDSGWFLCVATRDDKRDHRYIYLSVSGSSQNNAGISEVDSSQSYTSQSSSRFNIDYSPLVE 956

  Fly   144 QRIGAIFEVVCE---AQGVPQPVITWRLNGNVIQPQSNTGNRQ----SLILEIKSRNQAGLIECV 201
            .|.|...::.|.   ...:....|.|...|   ||.::..:.|    :|:::..:.:.:||..|.
Zfish   957 ARAGQTAKLQCSVLPVSAIHAVTIHWSRAG---QPLNSLRHSQHSDGTLVIKQLTADDSGLYTCT 1018

  Fly   202 ASNG------------VGEPAVANVYLHVLFSP-EVSIPQPVVYTKLGSRAHLECIVEAAPAATV 253
            .::.            :|:       |.:..:| :|.:.|       ||.|.|.|:| ......|
Zfish  1019 VTDAQKFEERQVQLRVLGD-------LRITKAPIDVDVVQ-------GSTAQLACVV-TGENVNV 1068

  Fly   254 KWFHHGLPVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVRNADMGQYECRA-SNQISVKS 317
            .|..:|:||....| ..|.|...|              |::.:|::.|.|.|.|.| :..:||.:
Zfish  1069 GWSRNGVPVRPDGH-RVHVSADGT--------------LILNNVQSVDEGTYTCNAYTGTLSVSA 1118

  Fly   318 GS-VELTGRPMPCLFKINPGTQSSTSHV 344
            .: :.|...|..   .|:.|..||:..|
Zfish  1119 AAEIRLAKTPQQ---DIDGGQFSSSDCV 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	24/106 (23%)
		IG_like	41..118	CDD:214653	23/100 (23%)
		IG_like	145..218	CDD:214653	15/91 (16%)
		Ig	147..219	CDD:299845	14/90 (16%)
		I-set	224..323	CDD:254352	26/100 (26%)
		IGc2	236..314	CDD:197706	22/78 (28%)
		FN3	339..431	CDD:238020	3/6 (50%)
paplna	XP_005169942.1	TSP1	24..75	CDD:214559
		ADAM_spacer1	181..293	CDD:310520
		TSP1	303..356	CDD:214559
		TSP1	388..442	CDD:214559
		TSP1	449..498	CDD:214559
		TSP1	504..557	CDD:214559
		KU	720..771	CDD:238057
		Ig_3	839..906	CDD:316449	22/75 (29%)
		IGc2	960..1022	CDD:197706	12/64 (19%)
		I-set	1039..1121	CDD:333254	27/104 (26%)
		PLAC	1142..1173	CDD:312271	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900