DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrapper and sdk1a

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_009297968.1	Gene:	sdk1a / 558391	ZFINID:	ZDB-GENE-081104-374	Length:	2245	Species:	Danio rerio

Alignment Length:	677	Identity:	127/677 - (18%)
Similarity:	202/677 - (29%)	Gaps:	249/677 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTPHMCSVVRCLLAALILGQVQAELDFNND-LENSQK---------------------------- 36
            |..:.| |||..:.||:..:.:.::.:..| ::|.|:
Zfish   185 MGVYQC-VVRNRMGALLQKKAEIQVAYMGDFIDNDQRKTVTQGRAAILNSPAVSCFPRPQVTWFR 248

  Fly    37 --FKSIPTT--VKTYENDTVQLPCTLNTPFRY---------------------------VRWHRD 70
              :|.||:.  ..|.||..|.|....:...||                           .|...|
Zfish   249 DGYKIIPSNRIAITLENQLVVLGTAASDAGRYYVQAVNEKNGENKTSPSIYLNVAANKKYRGSHD 313

  Fly    71 DVALVDSRHPELPPPDR-------------------------IMLWPNGSLQVA----------- 99
            ..|..|...|.:..|.|                         .::|....::||
Zfish   314 SEAPADPVAPVIVIPPRNTTVVAGISEATLECVANARPVEKLSLVWRRNGVEVASGVGSFSRRLT 378

  Fly   100 --NVQSSDTGDYYCE---MNSDSGHVVQQHAIEVQLAPQVLIEPSDLTEQRIGAIFEVVCEAQGV 159
              |..|:|.|.|.||   ::|.......:..:.:..||....||.......:....::.|:|:||
Zfish   379 IINPTSTDVGMYVCEALLLDSSVKPAEARAFLSITEAPYFTAEPRRKMMGEVEKSVDIQCQARGV 443

  Fly   160 PQPVITWRLNGNVIQPQSNTGNRQ-----SLILEIK--SRNQAGLIECVASNGVGEPAVANVYLH 217
            |.|.:.|..:.   .|.|...|.:     |:.|:::  ..:.||:.:|.|.|..|| |..:.||.
Zfish   444 PMPKLEWYKDA---VPLSKLNNPRYKIISSMGLQVRKLQPSDAGIFQCFARNSAGE-AQVHTYLD 504

  Fly   218 VL-FSPEVSIPQPVVYTKLGSRAHLECIVEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSV 281
            |. .:|..:.|...:....|:.|...|.|..||...:.|......:|.|:......:.|::..
Zfish   505 VTSMAPAFTAPPLDITVTDGAVAAFTCRVSGAPKPAIVWRRDTQILASGSVQIPRFTLLESGG-- 567

  Fly   282 DHYVNAVRHMLVVKSVRNADMGQYECRASNQISVKSGSVELT-------GRPMPCLFKINPGT-- 337
                      |.::.|...|.|.|.|.|:|.....:.|..||       ..| |...::..||
Zfish   568 ----------LQIQPVVLQDTGNYTCYAANSEGAINASASLTVWSRTSISSP-PTDRRVIKGTTA 621

  Fly   338 -----------------------------------QSSTSHV-LVW------------------Q 348
                                               |..:.|: ..|                  .
Zfish   622 ILECGATHDPRVGVRYVWKKDEELVSHSRGGRISLQEGSLHISQTWSGDIGNYTCDVISEAGNES 686

  Fly   349 TESLLPIMEFKLKFRQIPSN---NVTRQVRTNWTELTIPAQATNGLIYI---------------- 394
            .|:.|.::|.....|.:.::   |.:|.|..:|..   |....:.|::.
Zfish   687 KEARLEVIELPHSPRNLQASLNANDSRSVDLSWMR---PFDGNSPLLHYVVELSENNSPWRVYLS 748

  Fly   395 ------TTYTLHGLQPASLYEVSVLARNSFGWSDNSKIVRFATGGEVELPNYSTESELQDDFTEE 453
                  |...:.||.||..|:..|.|.|..|..                 .||||:
Zfish   749 DVDPSGTGAMVKGLTPARSYQFRVCAVNQVGRG-----------------QYSTET--------- 787

  Fly   454 DFHNEITQRSEVLSA--SMMFNSGSVN 478
               |.:..|.|..||  ..:..||..|
Zfish   788 ---NRLMLREEPPSAPPKNIVASGRTN 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	26/152 (17%)
		IG_like	41..118	CDD:214653	26/146 (18%)
		IG_like	145..218	CDD:214653	22/79 (28%)
		Ig	147..219	CDD:299845	22/78 (28%)
		I-set	224..323	CDD:254352	20/98 (20%)
		IGc2	236..314	CDD:197706	18/77 (23%)
		FN3	339..431	CDD:238020	22/135 (16%)
sdk1a	XP_009297968.1	I-set	125..208	CDD:254352	7/23 (30%)
		Ig	125..204	CDD:299845	7/19 (37%)
		IG_like	222..302	CDD:214653	10/79 (13%)
		Ig	236..287	CDD:299845	10/50 (20%)
		Ig_3	322..394	CDD:290638	12/71 (17%)
		I-set	323..412	CDD:254352	14/88 (16%)
		I-set	416..505	CDD:254352	25/92 (27%)
		Ig	436..500	CDD:299845	20/67 (30%)
		I-set	510..600	CDD:254352	22/101 (22%)
		Ig	527..600	CDD:299845	19/84 (23%)
		I-set	605..693	CDD:254352	9/88 (10%)
		Ig	610..693	CDD:299845	8/82 (10%)
		FN3	697..788	CDD:238020	21/122 (17%)
		fn3	800..886	CDD:278470	3/12 (25%)
		FN3	901..997	CDD:238020
		FN3	1002..1090	CDD:238020
		FN3	1100..1196	CDD:238020
		FN3	1206..1301	CDD:238020
		FN3	1308..1397	CDD:238020
		FN3	1408..1501	CDD:238020
		FN3	1507..1602	CDD:238020
		FN3	1616..1722	CDD:238020
		FN3	1732..1825	CDD:238020
		FN3	1830..1919	CDD:238020
		FN3	1931..2021	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900