DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wrapper and lrit1a

DIOPT Version :9

Sequence 1:NP_477404.1 Gene:wrapper / 37555 FlyBaseID:FBgn0025878 Length:500 Species:Drosophila melanogaster
Sequence 2:NP_001018174.2 Gene:lrit1a / 553943 ZFINID:ZDB-GENE-040924-5 Length:643 Species:Danio rerio


Alignment Length:462 Identity:89/462 - (19%)
Similarity:150/462 - (32%) Gaps:138/462 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 DLENSQKFKSIPTTVKTY----------ENDTVQLPC-TLNT-----------PFRYVRWHRDDV 72
            |:.|:| ..|:|:....|          .|:.:.:|. .|||           ..:.:....|:.
Zfish   137 DIHNNQ-LSSLPSEAALYMKNITYLDLSSNNLLTVPAEVLNTWLTIKPTLGAESSKLILGLHDNP 200

  Fly    73 ALVDSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQVLIE 137
            .|.|.|..:|     :....:.||.||.:   ||.....:..|.||.:.....:.....|:|...
Zfish   201 WLCDCRLYDL-----VQFQKSPSLSVAFI---DTRLRCADPESLSGVLFSDAELRRCQGPRVHTA 257

  Fly   138 PSDLTEQRIGAIFEVVCEAQGVPQPVITWR------LNGNVIQPQSNTGNRQSLI-LEIKSRNQA 195
            .:.: ...:|....:.|...|||.|.:.||      |||.|:...|..|...|:: :...|....
Zfish   258 VARV-RSAVGNNVLLRCGTVGVPIPELAWRRADGKPLNGTVLLENSKEGIVWSILSVPAVSYRDT 321

  Fly   196 GLIECVASNGVGEPAVANVYLHVLFSPEVSIPQPVVYTKLGSR------------AHLECIVEAA 248
            |...|.|:|..|. |.|.:.|.:..:|::..|......||.|:            .|:...|...
Zfish   322 GKYICKATNYAGS-AEAVISLIINDAPKMENPTLDPKPKLKSKKPNTMVKAAYQEKHIATYVSPT 385

  Fly   249 PAATVKWFHHGLPVA---------------------LGAHSTTHESELQTNRS------------ 280
            |       .:|||::                     :...:.:.:..|:||.|            
Zfish   386 P-------KNGLPLSGTVSYTGPYPGMESDNAANSRMNTQTASPDGFLETNLSNLAANTSSLQQD 443

  Fly   281 VDHYVNAVRHM------------------LVVKSVRNADMGQYECRASNQISVKSGSVELTGRPM 327
            .|..|.:|:.:                  ....||..|..|:.:.|   :|:|..|:..:     
Zfish   444 PDRVVRSVKVIGDTDYTVCLNWRAPTAKNTTAFSVLYAVFGERDMR---RINVSPGNNRI----- 500

  Fly   328 PCLFKINPGTQSSTSHVLVWQTESLLPIMEFKLKFRQIPSNNVTRQVRTNWTELTIPAQATNGLI 392
                 :..|....|.::.....:.|:|..|..:.|.               |:....|..|..||
Zfish   501 -----VIEGLVPKTKYIACVCVKGLIPKKEQCVIFS---------------TDAAASANGTQKLI 545

  Fly   393 YITTYTL 399
            .:...|:
Zfish   546 NVVVITV 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wrapperNP_477404.1 Ig 41..124 CDD:299845 21/104 (20%)
IG_like 41..118 CDD:214653 19/98 (19%)
IG_like 145..218 CDD:214653 24/79 (30%)
Ig 147..219 CDD:299845 24/78 (31%)
I-set 224..323 CDD:254352 25/161 (16%)
IGc2 236..314 CDD:197706 19/140 (14%)
FN3 339..431 CDD:238020 11/61 (18%)
lrit1aNP_001018174.2 leucine-rich repeat 61..84 CDD:275378
LRR_8 63..119 CDD:290566
LRR_RI <77..175 CDD:238064 8/38 (21%)
leucine-rich repeat 85..108 CDD:275378
LRR_8 108..167 CDD:290566 7/30 (23%)
leucine-rich repeat 109..132 CDD:275378
leucine-rich repeat 133..156 CDD:275378 6/19 (32%)
leucine-rich repeat 157..170 CDD:275378 1/12 (8%)
LRRCT 199..243 CDD:214507 13/51 (25%)
I-set 252..343 CDD:254352 26/92 (28%)
Ig 259..333 CDD:299845 20/74 (27%)
fn3 448..515 CDD:278470 12/79 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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