DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrapper and NTM

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001338930.1	Gene:	NTM / 50863	HGNCID:	17941	Length:	367	Species:	Homo sapiens

Alignment Length:	397	Identity:	98/397 - (24%)
Similarity:	162/397 - (40%)	Gaps:	93/397 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAALILGQVQAELDFNNDLENSQKFKSIP------TTVKTYENDTVQ------LPCTLNTPFRYV 65
            ||||.|                  |:.:|      |..|..:|.||:      |.||::.....|
Human    20 LAALCL------------------FQGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRV 66

  Fly    66 RW-HRDDVALVDSRHPELPPPDRIMLWPNG----SLQVANVQSSDTGDYYCEMNSDSGHVVQQHA 125
            .| :|..:....:....|.|  |::|..|.    |:::.||...|.|.|.|.:.:|:.....:..
Human    67 AWLNRSTILYAGNDKWCLDP--RVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVH 129

  Fly   126 IEVQLAPQVLIEPSDLTEQRIGAIFEVVCEAQGVPQPVITWRLNGNVIQPQSNTGNRQSLILEIK 190
            :.||::|:::...||::... |....:.|.|.|.|:|.:|||    .|.|::.....:...|||:
Human   130 LIVQVSPKIVEISSDISINE-GNNISLTCIATGRPEPTVTWR----HISPKAVGFVSEDEYLEIQ 189

  Fly   191 --SRNQAGLIECVASNGVGEPAVANVYLHVLFSPEVS------IPQPVVYTKLGSRAHLECIVEA 247
              :|.|:|..||.|||.|..|.|..|.:.|.:.|.:|      :|       :|.:..|:|...|
Human   190 GITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVP-------VGQKGTLQCEASA 247

  Fly   248 APAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVRNADMGQYECRASNQ 312
            .|:|..:|:.....:..|......|:....::.:  :.|...|          |.|.|.|.|||:
Human   248 VPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLI--FFNVSEH----------DYGNYTCVASNK 300

  Fly   313 ISVKSGSVELTGRPMPCLFKINPGTQSSTSHVLVWQTESLLP------IMEFKLKFRQIPSNNVT 371
            :...:.|:        .||::|..|.|:....:  :|.:|.|      :.|.        ||..:
Human   301 LGHTNASI--------MLFELNEPTSSTLLQEV--KTTALTPWKGPGAVSEV--------SNGTS 347

  Fly   372 RQVRTNW 378
            |:....|
Human   348 RRAGCVW 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	25/99 (25%)
		IG_like	41..118	CDD:214653	25/93 (27%)
		IG_like	145..218	CDD:214653	26/74 (35%)
		Ig	147..219	CDD:299845	26/73 (36%)
		I-set	224..323	CDD:254352	21/104 (20%)
		IGc2	236..314	CDD:197706	18/77 (23%)
		FN3	339..431	CDD:238020	9/46 (20%)
NTM	NP_001338930.1	Ig	44..132	CDD:416386	22/89 (25%)
		Ig strand A'	44..49	CDD:409353	3/4 (75%)
		Ig strand B	51..59	CDD:409353	2/7 (29%)
		CDR1	59..63	CDD:409353	0/3 (0%)
		FR2	64..70	CDD:409353	2/5 (40%)
		Ig strand C	64..70	CDD:409353	2/5 (40%)
		CDR2	71..83	CDD:409353	1/11 (9%)
		Ig strand C'	72..76	CDD:409353	0/3 (0%)
		Ig strand C'	80..83	CDD:409353	0/2 (0%)
		FR3	84..118	CDD:409353	12/35 (34%)
		Ig strand D	87..94	CDD:409353	2/6 (33%)
		Ig strand E	97..103	CDD:409353	1/5 (20%)
		Ig strand F	110..118	CDD:409353	3/7 (43%)
		CDR3	119..123	CDD:409353	1/3 (33%)
		Ig strand G	123..132	CDD:409353	0/8 (0%)
		FR4	125..132	CDD:409353	0/6 (0%)
		Ig_3	136..205	CDD:404760	23/73 (32%)
		Ig strand A'	142..147	CDD:409353	2/4 (50%)
		Ig strand B	153..160	CDD:409353	1/6 (17%)
		Ig strand C	166..171	CDD:409353	3/8 (38%)
		Ig strand D	177..180	CDD:409353	0/2 (0%)
		Ig strand E	184..190	CDD:409353	3/5 (60%)
		Ig strand F	197..204	CDD:409353	3/6 (50%)
		Ig strand G	211..219	CDD:409353	2/7 (29%)
		Ig_3	222..299	CDD:404760	19/95 (20%)
		putative Ig strand A	223..229	CDD:409353	2/5 (40%)
		Ig strand B	239..243	CDD:409353	1/3 (33%)
		Ig strand C	252..256	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	0/5 (0%)
		Ig strand F	292..297	CDD:409353	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810