DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrapper and klg

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	132/467 - (28%)
Similarity:	219/467 - (46%)	Gaps:	42/467 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KFKSIPTTVKTYENDTVQLPCTLNTPFRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGSLQVAN 100
            :|.|...|.:....||:.|||.:.....:|...|....::.:.:..:...:|:.|....:|::::
  Fly   102 RFLSRGHTYRAVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYNLEISD 166

  Fly   101 VQSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQV-LIEPSDLTEQRIGAIFEVVCEAQGVPQPVI 164
            ::..|.|||.|:: ||..:..|.|.:|:.:.|.| .|..|...:.|.|....:.|:..|.|.|.|
  Fly   167 LEPQDAGDYVCQI-SDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSI 230

  Fly   165 TWRLNGNVIQPQSNTGNRQSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPEVSIPQP 229
            .|.......:..:..|:...|.||...|.|||:.:|.|.||||:|...::.|.||:.|::.:.:.
  Fly   231 YWTKKSGANKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQVEKS 295

  Fly   230 VVYTKLGSRAHLECIVEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYVNAV---RHM 291
            .:::..|..|.|.|||.|.|.|||.|:.:..|:                :|.|..:.|.   |||
  Fly   296 WIHSGEGFEAKLVCIVFADPVATVSWYQNSFPI----------------QSTDRRIMATRANRHM 344

  Fly   292 LVVKSVRNADMGQYECRASNQISVKSGSVELTGRPMPCLFKINPGTQSSTSHVLVWQTESLLPIM 356
            |.::.::..|.|.|.|.|.|.:......:||:|||....|......:|..|:.|.|:.:|..|:.
  Fly   345 LTIRHIQQEDFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPLE 409

  Fly   357 EFKLKFRQIPSNNVTRQVRTNWTELTIPAQ---ATNGLIYITTYTLHGLQPASLYEVSVLARNSF 418
            |.:|.:|::..|. |.|....|.:..:..:   |:..|.:|.:||:..|.|...||..|.|:|.:
  Fly   410 EVRLLYRRVQMNE-TYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRY 473

  Fly   419 GWSDNSKIVRFATGGEVELPNYSTESELQDDFTEEDFHNEITQRSEVLSASMMFNSGSVNGRGGI 483
            ||::.|.|.:|..         :|.|:   |...||.....:.:|...|||:    ||:.|...:
  Fly   474 GWNEVSDIFQFVV---------ATNSQ---DIGPEDAEVVASSKSRSNSASI----GSLPGSTVL 522

  Fly   484 -SAFIYSLCLIN 494
             :|.:.:|.|.|
  Fly   523 HTALLLALALSN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	19/82 (23%)
		IG_like	41..118	CDD:214653	18/76 (24%)
		IG_like	145..218	CDD:214653	24/72 (33%)
		Ig	147..219	CDD:299845	23/71 (32%)
		I-set	224..323	CDD:254352	27/101 (27%)
		IGc2	236..314	CDD:197706	26/80 (33%)
		FN3	339..431	CDD:238020	30/94 (32%)
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	8/21 (38%)
		IG_like	109..195	CDD:214653	21/86 (24%)
		Ig	118..191	CDD:143165	17/73 (23%)
		IG_like	205..274	CDD:214653	22/68 (32%)
		IGc2	213..273	CDD:197706	19/59 (32%)
		IGc2	301..367	CDD:197706	26/81 (32%)
		FN3	392..486	CDD:238020	30/94 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4772
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14108
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45080
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.970