DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrapper and bdl

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	105/470 - (22%)
Similarity:	176/470 - (37%)	Gaps:	127/470 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPTTVKTY-ENDTVQLPCTLNTPFR-YVRWHRDDVALVDSRHPELPPPD---RIMLWPNGSLQVA 99
            ||...:|. |..|....|.:..|.. ...|::|.|.|.:.:       |   |..:.|:|||.:.
  Fly   155 IPPVNQTIREGQTAFFHCVMKHPENSQASWYKDGVLLQEVQ-------DLVRRFYMGPDGSLSID 212

  Fly   100 NVQSSDTGDYYCEMNSDSGHV--------VQQHAIEVQLAPQVLI---EPS-------------D 140
            ....||.|:|.|::.:..|.:        :|..|..:...|:|.:   :|:             :
  Fly   213 PTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKN 277

  Fly   141 LTEQRIGAIFEVVCEAQGVPQPVITWRLNGNVIQPQSNTGNRQSLILEIKSRNQAGLIECVASNG 205
            |..::.|.:|    ::..||.  :.:::||             ||.......|.||...|...|.
  Fly   278 LRWEKDGLLF----DSYNVPG--VFYKMNG-------------SLFFAKVDENHAGSYTCTPYND 323

  Fly   206 VG----EPAVANVYLHVLFSPEVSI-PQPVVYTKLGSRAHLECIVEAAP-----AATVKWFH-HG 259
            :|    .|.::.:   ||..|..|: |:.:...|||..|.|.|  ||..     ..::.|.. .|
  Fly   324 LGTDGPSPVISVI---VLRPPIFSVTPKAIYIQKLGEAAELPC--EAIDRDGNNRPSIIWGRKDG 383

  Fly   260 LPVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVRNADMGQYECRASNQISVKSGSVELTG 324
            .|:.....|.:..:                  |.:..:...|.|.|||.|:|:.:..:...||
  Fly   384 QPLPADRFSLSGGN------------------LTITGLVEGDRGIYECSATNEAATITAEAEL-- 428

  Fly   325 RPMPCLFKINPG-----TQSSTSHVLV--WQTESLLPIMEFKLKFRQIPSNNVTRQVRTNWTELT 382
                .:..|.|.     |.:||...:.  ||...|.|.:|:.:.:|.:.:        ..|..|.
  Fly   429 ----MIENIAPRAPYNLTANSTETCITIRWQPGYLRPNLEYTVWYRLMEA--------PEWRTLR 481

  Fly   383 IPAQATNGLIYITTYTLHGLQPASLYEVSVLARNSFGWSDNSKIVRFATGGEVELPNYSTESELQ 447
            :..:.      :...|:..|||...||..||:::.:|....||..||.|     ||     |.::
  Fly   482 VLDKK------VMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQT-----LP-----SPIR 530

  Fly   448 -DDFTEEDFHNEITQ 461
             |||..:...:::.|
  Fly   531 ADDFDAQQLQHDLGQ 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	23/95 (24%)
		IG_like	41..118	CDD:214653	21/81 (26%)
		IG_like	145..218	CDD:214653	15/76 (20%)
		Ig	147..219	CDD:299845	15/75 (20%)
		I-set	224..323	CDD:254352	23/105 (22%)
		IGc2	236..314	CDD:197706	18/83 (22%)
		FN3	339..431	CDD:238020	23/93 (25%)
bdl	NP_608822.1	IG_like	42..128	CDD:214653
		Ig	43..131	CDD:299845
		I-set	153..242	CDD:254352	23/93 (25%)
		Ig	157..242	CDD:299845	21/91 (23%)
		Ig_2	252..337	CDD:290606	19/106 (18%)
		IG_like	260..327	CDD:214653	16/85 (19%)
		I-set	341..428	CDD:254352	23/106 (22%)
		IGc2	356..419	CDD:197706	18/82 (22%)
		FN3	435..524	CDD:238020	25/102 (25%)
		FN3	554..636	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900