DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrapper and itgb4

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	374	Identity:	71/374 - (18%)
Similarity:	125/374 - (33%)	Gaps:	117/374 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 PQPVITWRLNGNVIQPQSNT--GNRQSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSP 222
            |.|:|..:.|..::.|.:|.  |.|::             .|.:.::|.|:....:.......:.
Zfish  1179 PSPIIPEKFNLELLDPSNNAIIGKRKT-------------TEVIVTDGRGDGKNQDFQKMEYVTQ 1230

  Fly   223 EVSIPQPVVYTKLGSRAHLECIVEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYVNA 287
            ..:.|...:|    |.|:::.:........:.|               ..|:......|.:::
Zfish  1231 TATSPGGRLY----SPANIKAVATGPKNIRLNW---------------KPSQNANGYKVKYWI-- 1274

  Fly   288 VRHMLVVKSVRNADMGQYECRASNQISVKSGSVELTGRPMPCLFKI-----NPGTQSSTSHVLVW 347
                          .|..|.:| ..:.||:...|||.....|.:::     |.....:.|.::..
Zfish  1275 --------------YGDPEDKA-KFMDVKTPQAELTNLDPYCDYEMRVCGYNALGDGNYSDIIQC 1324

  Fly   348 QTESLLPIMEFKLKFRQIPSNNVTRQVRTNWTELTIPAQATNGLI--YITTY------------- 397
            ||...:|....:|.|..| |..||   :.:|.|   ||:| ||:|  |...|
Zfish  1325 QTLEDIPGEPGRLAFNVI-SPTVT---QVSWAE---PAEA-NGIITGYEVIYMPINEDKKPTGPP 1381

  Fly   398 -------------TLHGLQPASLYEVSVLARNSFGWSDNSKIVRFATGGEVELPNYST------- 442
                         .:..|||:..|...|.|.|..||..    .|.||   :.|.:..|
Zfish  1382 KKVMIDNPKKRMLLIENLQPSQTYCYKVRASNKVGWGP----YREAT---INLASQPTRPMSIPI 1439

  Fly   443 --ESELQDDFTEEDFHNEITQRSEVL---------SASMMFNSGSVNGR 480
              :..:.|....|::.:.:...:|||         |.:.:.:...|||:
Zfish  1440 IPDIPIVDAEAGEEYDSYLMYSNEVLRSPTSSLRPSVTDLSDDQFVNGK 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845
		IG_like	41..118	CDD:214653
		IG_like	145..218	CDD:214653	11/59 (19%)
		Ig	147..219	CDD:299845	11/60 (18%)
		I-set	224..323	CDD:254352	13/98 (13%)
		IGc2	236..314	CDD:197706	8/77 (10%)
		FN3	339..431	CDD:238020	30/119 (25%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020	15/115 (13%)
		FN3	1331..1420	CDD:238020	26/100 (26%)
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900