DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrapper and Fas2

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	103/458 - (22%)
Similarity:	180/458 - (39%)	Gaps:	83/458 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SIPTTVKTYENDTVQLPCTL-NTPFRYVRWHRDDVALVDSRHPELPPPDRIMLWP-NGSLQVANV 101
            |:||.::..|.......||. ..|...:.|.||...|      .:...||..:.| .|.:.:::|
  Fly   234 SLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQL------NVATADRFQVNPQTGLVTISSV 292

  Fly   102 QSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQVLIEPSDLTEQRIGAIFEVVCEAQGVPQPVITW 166
            ...|.|.|.|...:.:|.|.|:..:.|.:.||: .|..::|..|...| .:.|.|:|.|.|.||:
  Fly   293 SQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQI-YELYNVTGARTKEI-AITCRAKGRPAPAITF 355

  Fly   167 R--------LNGN-------VIQPQ------SNTGNRQSLILEIKSRNQAGLIECVASNGVGEPA 210
            |        .||.       :::|.      .:||   :|.:....|:..||.:|:|.| .|..|
  Fly   356 RRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTG---TLRISNAERSDDGLYQCIARN-KGADA 416

  Fly   211 VANVYLHVLFSPEVSIPQ--PVVYTKLGSRAHLECIVEAAPAATVKWFHHGLPVALGAHSTTHES 273
            ....::.|.|:|:.|..:  |.|::....:|:|.|:....|.||::|..:|..:         :.
  Fly   417 YKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKI---------KD 472

  Fly   274 ELQTNRSVDHYVNAVRHMLVVKSVRNADMGQYECRASNQISVKSGSVELTGRPMP-CLFKINPGT 337
            ...||..:  .....|..|:|..|.......|:|.|:|........::|....:| .:.:..|..
  Fly   473 LYDTNLKI--VGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQ 535

  Fly   338 QSSTS---HVLVWQTESLLPIMEFKLKFRQIPSNNVTRQVRTNWTELTIPAQATNGLIYITTYTL 399
            .::|:   .:....||..|||:.:.:::::..:.:.:.....:|:.             .:.|.:
  Fly   536 LTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSP-------------DSPYIV 587

  Fly   400 HGLQPASLYEVSVLARNSFG---WSDNSKIVRFATGGEVELPNYSTESELQDDFTEEDFHNEITQ 461
            .||:|.:.|.....|||..|   |..|.         :...|..|...|      .:..||.:..
  Fly   588 EGLRPQTEYSFRFAARNQVGLGNWGVNQ---------QQSTPRRSAPEE------PKPLHNPVQH 637

  Fly   462 RSE 464
            ..|
  Fly   638 DKE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	22/84 (26%)
		IG_like	41..118	CDD:214653	19/78 (24%)
		IG_like	145..218	CDD:214653	24/93 (26%)
		Ig	147..219	CDD:299845	23/92 (25%)
		I-set	224..323	CDD:254352	21/100 (21%)
		IGc2	236..314	CDD:197706	18/77 (23%)
		FN3	339..431	CDD:238020	18/97 (19%)
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653
		IGc2	152..209	CDD:197706
		I-set	230..319	CDD:254352	23/90 (26%)
		IGc2	243..309	CDD:197706	17/71 (24%)
		IG_like	330..424	CDD:214653	25/98 (26%)
		IGc2	339..412	CDD:197706	21/77 (27%)
		Ig	447..518	CDD:143165	18/81 (22%)
		fn3	534..611	CDD:278470	16/89 (18%)
		FN3	640..735	CDD:238020	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900