DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrapper and Igsf9

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	118/524 - (22%)
Similarity:	182/524 - (34%)	Gaps:	147/524 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LILGQVQAELDFNN------DLENSQKFKSIPTTV-KTYENDTVQLPC-TLNTPFRYVRWHRDDV 72
            |.|.|...|.||.|      .:.:..:|:..|..| :..|.:.|.|.| .|.:|..||.|
  Rat   111 LFLDQHSPEQDFANGSWVHLTVNSPPQFQETPPLVLEVKELEAVTLRCVALGSPQPYVTW----- 170

  Fly    73 ALVDSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQVLIE 137
               ..|..:|......:...||:|.:..|:....|||.|:.:|..|.|.....:.| |.|.|::.
  Rat   171 ---KFRGQDLGKGQGQVQVRNGTLWIRRVERGSAGDYTCQASSTEGSVTHTTQLLV-LGPPVIVV 231

  Fly   138 PSDLTEQRIGAIFEVVCEAQGVPQPV-ITW---RLN-GNVIQPQSNT-----GNRQSLILEIKSR 192
            |.:...........:.|.|:..|..: .:|   |:| .::.:.||..     |   ||.|:....
  Rat   232 PPNNNTVNASQDVSLACRAEAYPANLTYSWFQDRINVFHISRLQSRVRILVDG---SLWLQATQP 293

  Fly   193 NQAGLIECVASNGVGEPAVANVYLHVLFSPEVSIPQPVVYTKLGSRAHLECIVEA-APAATVKWF 256
            :.||...||.|||...|..|:.||.||:..:|::..|.....:|.|..:.|.|.| .|...|.|.
  Rat   294 DDAGHYTCVPSNGFPHPPSASAYLTVLYPAQVTVMPPETPLPIGMRGVIRCPVRANPPLLFVTWT 358

  Fly   257 HHGLPV------------------------ALGAHSTTHESELQT------------------NR 279
            ..|..:                        |||.:|.|..:.|.|                  ::
  Rat   359 KDGQALQLDKFPGWSLGPEGSLVIALGNEDALGEYSCTPYNSLGTAGSSPVTRVLLKAPPAFIDQ 423

  Fly   280 SVDHYVNAV-----------------------------------RHMLVVKSVRNADMGQYECRA 309
            ..:.|...|                                   .:.|:::.:.....|::||.|
  Rat   424 PKEEYFQEVGRDLLIPCSARGDPPPIVSWAKVGRGLQGQAQVDSNNSLILRPLTKEAHGRWECSA 488

  Fly   310 SNQIS--VKSGSVELTGR-----------PMPCLFKIN--PGTQSS-TSHVLVWQTESLLPIMEF 358
            .|.::  ..|.:|.:.|.           |:|....::  ||.... .....||.|
  Rat   489 RNAVAHVTISTNVYVLGTSPHVVTNVSVVPLPKGANVSWEPGFDGGYLQRFSVWYT--------- 544

  Fly   359 KLKFRQIPSNNVTRQVRTNWTELTIPAQATNGLIYITTYTLHGLQPASLYEVSVLARNSFGWSDN 423
                   |......:...:|..|.:|..||:.|:       .|||..:.|:.||||:|..|....
  Rat   545 -------PLAKRPDRAHHDWVSLAVPMGATHLLV-------PGLQAYTQYQFSVLAQNKLGSGPF 595

  Fly   424 SKIV 427
            |:||
  Rat   596 SEIV 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	24/84 (29%)
		IG_like	41..118	CDD:214653	22/78 (28%)
		IG_like	145..218	CDD:214653	23/82 (28%)
		Ig	147..219	CDD:299845	23/81 (28%)
		I-set	224..323	CDD:254352	28/178 (16%)
		IGc2	236..314	CDD:197706	24/155 (15%)
		FN3	339..431	CDD:238020	23/90 (26%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652
		Ig strand A	136..139	CDD:409353	0/2 (0%)
		IG_like	143..223	CDD:214653	23/87 (26%)
		Ig strand A'	145..148	CDD:409353	1/2 (50%)
		Ig strand B	154..161	CDD:409353	3/6 (50%)
		Ig strand C	167..172	CDD:409353	3/12 (25%)
		Ig strand C'	175..177	CDD:409353	0/1 (0%)
		Ig strand D	183..187	CDD:409353	0/3 (0%)
		Ig strand E	189..193	CDD:409353	2/3 (67%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	2/9 (22%)
		Ig_3	226..305	CDD:404760	19/81 (23%)
		putative Ig strand A	226..230	CDD:409353	2/3 (67%)
		putative Ig strand A'	235..239	CDD:409353	0/3 (0%)
		putative Ig strand B	241..251	CDD:409353	1/9 (11%)
		putative Ig strand C'	267..270	CDD:409353	1/2 (50%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	4/8 (50%)
		putative Ig strand F	297..305	CDD:409353	3/7 (43%)
		putative Ig strand G	310..319	CDD:409353	4/8 (50%)
		Ig	322..407	CDD:416386	18/84 (21%)
		Ig strand A'	324..328	CDD:409353	1/3 (33%)
		Ig strand B	333..347	CDD:409353	3/13 (23%)
		Ig strand C	353..359	CDD:409353	2/5 (40%)
		Ig strand C'	362..364	CDD:409353	0/1 (0%)
		Ig strand D	371..374	CDD:409353	0/2 (0%)
		Ig strand E	378..382	CDD:409353	0/3 (0%)
		Ig strand F	391..399	CDD:409353	3/7 (43%)
		Ig	418..503	CDD:416386	10/84 (12%)
		Ig strand A	418..421	CDD:409353	0/2 (0%)
		Ig strand A'	427..430	CDD:409353	1/2 (50%)
		Ig strand B	436..443	CDD:409353	0/6 (0%)
		Ig strand C	449..454	CDD:409353	0/4 (0%)
		Ig strand C'	457..459	CDD:409353	0/1 (0%)
		Ig strand D	462..466	CDD:409353	0/3 (0%)
		Ig strand E	469..473	CDD:409353	1/3 (33%)
		Ig strand F	482..490	CDD:409353	4/7 (57%)
		Ig strand G	493..503	CDD:409353	2/9 (22%)
		FN3	508..599	CDD:238020	25/113 (22%)
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900