DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrapper and ncam1a

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	446	Identity:	120/446 - (26%)
Similarity:	186/446 - (41%)	Gaps:	83/446 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NDTVQLPCTLN-TPFRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGS-LQVANVQSSDTGDYYC 111
            |..|.|.|..: .|...|:|.|.:.        ||...::..|..:|| |.:.:|...|.|||.|
Zfish   225 NQAVTLACHADGYPEPTVKWARGNT--------ELESDEKYSLNEDGSELTIKDVNKLDEGDYKC 281

  Fly   112 EMNSDSGHVVQQHAIEVQLAPQVLI----EPSDLTEQRIGAIFEVVCEAQGVPQPVITW------ 166
            ...:.:|...::..:.|.:.|::..    ..|:|.||     ..:.|||.|.|.|.|.|
Zfish   282 IARNKAGERSEEVTLNVFVQPKITFLENQTASELEEQ-----ITLTCEATGDPTPNIIWSFGRRV 341

  Fly   167 ----------------RLNGNVIQPQSNTGNRQSLILEIKSRNQAGLIECVASNGVGEPAVANVY 215
                            .|:|||:  ..:.....||.|:......||...|.|.|.:|:. :.::|
Zfish   342 FTENEQASWTRPEKHKSLDGNVV--VRSDARVSSLTLKYVQFTDAGQYLCTARNSIGQD-IQSMY 403

  Fly   216 LHVLFSPEVSIPQPVVYTKLGSRAHLECIVEAAPAATVKWFHHG--LPVALGAHSTTHESELQTN 278
            |.|.::|::..|| .|:|..|:.|::.|...|.|.|:|.||..|  ||.|    :||
Zfish   404 LEVRYAPKIQGPQ-AVFTWEGNPANITCEALAHPGASVLWFRDGQQLPSA----NTT-------- 455

  Fly   279 RSVDHYVNAVRHMLVVKSVRNADMGQYECRASNQISVKSGS---VELTGRPMPCLFKINPGTQSS 340
             :|..|.......|.|......|.|.|.|.|:|.|..:|..   |:......|.:.::.|  .||
Zfish   456 -NVKIYNTPTVSFLEVTPDSQNDFGSYNCTATNVIGTESKEFILVQADVPSAPSIERVEP--YSS 517

  Fly   341 TSHVLVWQTESL--LPIMEFKLKFRQIPSNNVTRQVRTNWTELTIPAQATNGLIYITTYTLHGLQ 403
            |:.:...:..|.  :|::::|.::|      :..|   :||:...  :..:||..|   |:.||:
Zfish   518 TAMIEFEEPASSGGVPVLKYKAEWR------IAGQ---DWTDREY--ELEDGLNLI---TIVGLK 568

  Fly   404 PASLYEVSVLARNSFGWSDNSKIVRFATGGEVELP-NYSTESELQDDFTEEDFHNE 458
            |.:.|||.:.|.|..|..::|....|.| ..|.|| ..|.|:......|..|...|
Zfish   569 PETTYEVKISAINGKGEGESSAPESFKT-QPVRLPFRMSPETPTSIPPTTADIKGE 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	21/76 (28%)
		IG_like	41..118	CDD:214653	20/70 (29%)
		IG_like	145..218	CDD:214653	23/94 (24%)
		Ig	147..219	CDD:299845	23/93 (25%)
		I-set	224..323	CDD:254352	32/103 (31%)
		IGc2	236..314	CDD:197706	25/79 (32%)
		FN3	339..431	CDD:238020	25/93 (27%)
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845
		I-set	21..111	CDD:254352
		IG_like	121..200	CDD:214653
		IGc2	128..189	CDD:197706
		Ig	208..301	CDD:299845	22/83 (27%)
		IG_like	219..298	CDD:214653	21/80 (26%)
		Ig	300..406	CDD:299845	28/113 (25%)
		IG_like	308..406	CDD:214653	27/105 (26%)
		ig	413..498	CDD:278476	31/98 (32%)
		IG_like	415..498	CDD:214653	31/96 (32%)
		fn3	505..589	CDD:278470	25/99 (25%)
		FN3	624..715	CDD:238020	120/446 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810