DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrapper and Ncam1

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	113/491 - (23%)
Similarity:	197/491 - (40%)	Gaps:	111/491 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GQVQAELDFNNDLENSQKFKSIPTTVKTYEN---------DTVQLPCTLN-TPFRYVRWHRDDVA 73
            |::.|..:.|  .::.|...::|.||:..::         .:|.|.|..: .|...:.|.:|...
  Rat   191 GRILARGEIN--FKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEP 253

  Fly    74 LV-----DSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQ 133
            :.     |.:|        |....:..|.:.||..:|..:|.|...:.:|.......::|...|:
  Rat   254 IENEEEDDEKH--------IFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPK 310

  Fly   134 VLIEPS----DLTEQRIGAIFEVVCEAQGVPQPVITWRLN-GNVIQPQSNTGNR----------- 182
            :....:    :|.||     ..:.|||.|.|.|.||||.: .|:...:..:..|
  Rat   311 ITYVENQTAMELEEQ-----VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHM 370

  Fly   183 --------QSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPEVSIPQPVVYTKLGSRA 239
                    .||.|:......||...|.|||.:|:.: .::||.|.::|::..| ..|||..|::.
  Rat   371 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS-QSMYLEVQYAPKLQGP-VAVYTWEGNQV 433

  Fly   240 HLECIVEAAPAATVKWFHHG--LPVA----LGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVR 298
            ::.|.|.|.|:||:.||..|  ||.:    :..::|...|.|:.....::
  Rat   434 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN--------------- 483

  Fly   299 NADMGQYECRASNQISVKSGS---VELTGRPMPCLFKINPGTQSSTSHVLVWQTESL--LPIMEF 358
              |.|.|.|.|.|:|..:|..   |:......|.:.::.|  .|||:.|...:.|:.  :||:::
  Rat   484 --DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEP--YSSTAQVQFDEPEATGGVPILKY 544

  Fly   359 KLKFRQIPSNNVTRQVRTNWTELTIPAQATN--GLIYITTYTLHGLQPASLYEVSVLARNSFGWS 421
            |.:::.:...        .|......|:..|  |::     |:.||:|.:.|.|.:.|.|..|..
  Rat   545 KAEWKSLGEE--------AWHSKWYDAKEANMEGIV-----TIMGLKPETRYAVRLAALNGKGLG 596

  Fly   422 DNSKIVRFAT--------GGEVELPNYSTESELQDD 449
            :.|....|.|        .||...|  ..|.::.:|
  Rat   597 EISAATEFKTQPVHSPPPQGEPSAP--KLEGQMGED 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	19/97 (20%)
		IG_like	41..118	CDD:214653	18/91 (20%)
		IG_like	145..218	CDD:214653	24/92 (26%)
		Ig	147..219	CDD:299845	24/91 (26%)
		I-set	224..323	CDD:254352	28/107 (26%)
		IGc2	236..314	CDD:197706	21/83 (25%)
		FN3	339..431	CDD:238020	23/95 (24%)
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451
		Ig strand B	37..41	CDD:409451
		Ig strand C	51..55	CDD:409451
		Ig strand E	79..83	CDD:409451
		Ig strand F	93..98	CDD:409451
		Ig strand G	107..110	CDD:409451
		IG_like	124..190	CDD:214653
		Ig strand B	135..139	CDD:409353
		Ig strand C	148..152	CDD:409353
		Ig strand E	172..176	CDD:409353
		Ig strand F	186..191	CDD:409353	113/491 (23%)
		IgI_3_NCAM-1	211..308	CDD:143207	20/104 (19%)
		Ig strand B	231..235	CDD:143207	2/3 (67%)
		Ig strand C	244..248	CDD:143207	0/3 (0%)
		Ig strand E	271..275	CDD:143207	1/3 (33%)
		Ig strand F	285..290	CDD:143207	2/4 (50%)
		Ig strand G	298..301	CDD:143207	0/2 (0%)
		IgI_NCAM-1	307..413	CDD:143277	28/111 (25%)
		Ig strand B	326..330	CDD:143277	0/3 (0%)
		Ig strand C	339..343	CDD:143277	2/3 (67%)
		Ig strand E	379..383	CDD:143277	2/3 (67%)
		Ig strand F	393..398	CDD:143277	1/4 (25%)
		Ig strand G	406..409	CDD:143277	0/3 (0%)
		Ig_3	422..494	CDD:404760	24/89 (27%)
		Ig strand B	433..437	CDD:409353	0/3 (0%)
		Ig strand C	446..450	CDD:409353	1/3 (33%)
		Ig strand E	473..477	CDD:409353	2/3 (67%)
		Ig strand F	487..492	CDD:409353	2/4 (50%)
		FN3	509..606	CDD:238020	25/111 (23%)
		fn3	619..701	CDD:394996	3/14 (21%)
		Herpes_BLLF1	<842..1133	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900