DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrapper and Sdk2

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	396	Identity:	101/396 - (25%)
Similarity:	158/396 - (39%)	Gaps:	65/396 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VQLPC-TLNTPFRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNS 115
            |.:|| ....|...:.|:: |.|||     |:....|.....:|.||::.:...|||...|..::
Mouse   330 VDIPCRAKGVPPPSITWYK-DAALV-----EVGKLTRFKQRSDGGLQISGLLPDDTGMLQCFAHN 388

  Fly   116 DSGHVVQQHAIEV-QLAPQVLIEPSDLTEQRIGAIFEVVCEAQGVPQPVITWR------LNGNVI 173
            .:|.......:.| .:||.:...|.|.|... |....:.||..|.|:|.|||:      .:|:|.
Mouse   389 AAGEAQTSTYLAVTSIAPNITRGPLDSTVID-GMSVVLACETSGAPRPAITWQKGERILASGSVQ 452

  Fly   174 QPQSNTGNRQSLILEIKSRNQAGLIECVASN--GVGEPAVANVYLHVLFSPEVSIP---QPVVYT 233
            .|:.......||::.....:.||...|:|:|  ||.|   |:..|.|.....::.|   |.|:
Mouse   453 LPRFTLLESGSLLISPTHISDAGTYTCLATNSRGVDE---ASADLVVWARTRITKPPQDQSVI-- 512

  Fly   234 KLGSRAHLECIVEAAPAATVK--WFHHGLPVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKS 296
             .|::|.:.|.|...|..||:  |...|..:|:   .|.....|..|.|           |.:..
Mouse   513 -KGTQASMVCGVTHDPRVTVRYVWEKDGATLAV---ETNPRIRLDRNGS-----------LHISQ 562

  Fly   297 VRNADMGQYECRASNQISVKSGSVELTGRPMPCLFKINPGTQSSTSH---VLVWQT--ESLLPIM 356
            ..:.|:|.|.||..:.....|.:..|..|.:|...:....|.|:...   .|.|..  :...|:|
Mouse   563 TWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAPEHPVATLSTVERRAINLTWAKPFDGNSPLM 627

  Fly   357 EFKLKFRQIPSNNVTRQVRTNWTEL--TIPAQATNGLIYITTYTLHGLQPASLYEVSVLARNSFG 419
            .:.|   ::..||..      ||.|  ::..:||:.::       .||.||..|:..:.|.|..|
Mouse   628 RYVL---EMSENNAP------WTILLASVDPEATSVMV-------KGLVPARSYQFRLCAVNDVG 676

  Fly   420 WSDNSK 425
            ....||
Mouse   677 KGQFSK 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	19/72 (26%)
		IG_like	41..118	CDD:214653	18/66 (27%)
		IG_like	145..218	CDD:214653	24/80 (30%)
		Ig	147..219	CDD:299845	24/79 (30%)
		I-set	224..323	CDD:254352	24/103 (23%)
		IGc2	236..314	CDD:197706	20/79 (25%)
		FN3	339..431	CDD:238020	23/94 (24%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653
		IGc2	44..102	CDD:197706
		IG_like	124..207	CDD:214653
		Ig	136..192	CDD:299845
		IG_like	226..308	CDD:214653
		IGc2	237..290	CDD:197706
		I-set	312..401	CDD:254352	19/76 (25%)
		Ig	330..398	CDD:143165	19/73 (26%)
		I-set	406..496	CDD:254352	28/93 (30%)
		Ig	420..496	CDD:299845	24/78 (31%)
		Ig	506..590	CDD:299845	24/100 (24%)
		IG_like	506..590	CDD:214653	24/100 (24%)
		FN3	594..685	CDD:238020	25/105 (24%)
		FN3	697..790	CDD:238020
		FN3	798..894	CDD:238020
		FN3	899..987	CDD:238020
		FN3	997..1091	CDD:238020
		FN3	1103..1198	CDD:238020
		FN3	1205..1294	CDD:238020
		FN3	1305..1398	CDD:238020
		FN3	1404..1488	CDD:238020
		FN3	1507..1620	CDD:238020
		FN3	1630..1723	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734
		FN3	1728..1809	CDD:238020
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900