DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wrapper and Ncam1

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	465	Identity:	108/465 - (23%)
Similarity:	190/465 - (40%)	Gaps:	101/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GQVQAELDFNNDLENSQKFKSIPTTVKTYEN---------DTVQLPCTLN-TPFRYVRWHRDDVA 73
            |::.|..:.|  .::.|...::|.||:..::         .:|.|.|..: .|...:.|.:|...
Mouse   191 GRILARGEIN--FKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEP 253

  Fly    74 LV-----DSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQ 133
            :.     |.:|        |....:..|.:.||..:|..:|.|...:.:|.......::|...|:
Mouse   254 IENEEEDDEKH--------IFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPK 310

  Fly   134 VLIEPS----DLTEQRIGAIFEVVCEAQGVPQPVITWRLN-GNVIQPQSNTGNR----------- 182
            :....:    :|.||     ..:.|||.|.|.|.||||.: .|:...:..:..|
Mouse   311 ITYVENQTAMELEEQ-----VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHM 370

  Fly   183 --------QSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPEVSIPQPVVYTKLGSRA 239
                    .||.|:......||...|.|||.:|:.: .::||.|.::|::..| ..|||..|::.
Mouse   371 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS-QSMYLEVQYAPKLQGP-VAVYTWEGNQV 433

  Fly   240 HLECIVEAAPAATVKWFHHG--LPVA----LGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVR 298
            ::.|.|.|.|:||:.||..|  ||.:    :..::|...|.|:.....::
Mouse   434 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN--------------- 483

  Fly   299 NADMGQYECRASNQISVKSGS---VELTGRPMPCLFKINPGTQSSTSHVLVWQTESL--LPIMEF 358
              |.|.|.|.|.|:|..:|..   |:......|.:.::.|  .|||:.|...:.|:.  :||:::
Mouse   484 --DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEP--YSSTAQVQFDEPEATGGVPILKY 544

  Fly   359 KLKFRQIPSNNVTRQVRTNWTELTIPAQATN--GLIYITTYTLHGLQPASLYEVSVLARNSFGWS 421
            |.:::.:...        :|......|:..|  |::     |:.||:|.:.|.|.:.|.|..|..
Mouse   545 KAEWKSLGEE--------SWHFKWYDAKEANMEGIV-----TIMGLKPETRYSVRLAALNGKGLG 596

  Fly   422 DNSKIVRFAT 431
            :.|....|.|
Mouse   597 EISAATEFKT 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	19/97 (20%)
		IG_like	41..118	CDD:214653	18/91 (20%)
		IG_like	145..218	CDD:214653	24/92 (26%)
		Ig	147..219	CDD:299845	24/91 (26%)
		I-set	224..323	CDD:254352	28/107 (26%)
		IGc2	236..314	CDD:197706	21/83 (25%)
		FN3	339..431	CDD:238020	23/95 (24%)
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652
		Ig3_NCAM-1_like	211..308	CDD:143207	20/104 (19%)
		Ig_NCAM-1	307..413	CDD:143277	28/111 (25%)
		Ig_3	417..494	CDD:372822	25/94 (27%)
		FN3	509..606	CDD:238020	25/111 (23%)
		fn3	649..731	CDD:365830
		PHA03247	<905..1140	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900