DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wrapper and Dscam

DIOPT Version :9

Sequence 1:NP_477404.1 Gene:wrapper / 37555 FlyBaseID:FBgn0025878 Length:500 Species:Drosophila melanogaster
Sequence 2:XP_038943864.1 Gene:Dscam / 171119 RGDID:619992 Length:2034 Species:Rattus norvegicus


Alignment Length:497 Identity:104/497 - (20%)
Similarity:183/497 - (36%) Gaps:101/497 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LILGQVQAELD---------FNNDLENSQKFK---SIPTTVKTYE------NDTVQLPCTL---N 59
            |.|..||.|:|         ....|..||...   .:|..::.:|      ...|.:||.:   :
  Rat   559 LKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGD 623

  Fly    60 TPFRYVRWHRDDVALVDSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQH 124
            .|.. :.|.:|...:..|....:   |.|..  ..||:::|:.....|:|.|...:::..|..|.
  Rat   624 LPIT-ITWQKDGRPIPASLGVTI---DNIDF--TSSLRISNLSLMHNGNYTCIARNEAAAVEHQS 682

  Fly   125 AIEVQLAPQVLIEPSDLTEQRIGAIFEVVCEAQGVPQPVITWR--------------LNGNVIQP 175
            .:.|::.|:.:::|.| .:...|....:.|.|:|.|.|.|.|:              |||. ||.
  Rat   683 QLIVRVPPKFVVQPRD-QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR-IQV 745

  Fly   176 QSNTGNRQSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPEV-SIPQPVVYTKLGSRA 239
            .||    .||:::......:|...|..||.||.....::||.|.....: |.|...:.|: |.|.
  Rat   746 LSN----GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQ-GQRK 805

  Fly   240 HLECIVEAAPAATVKWFHHGLPVALGAHSTTHESELQTNRSVDHYV--------NAVRHMLVVKS 296
            .:.|.........|:|               .:.:...|..:..|:        ..:..:.::.:
  Rat   806 EMSCTAHGEKPIIVRW---------------EKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855

  Fly   297 VRNADMGQYECRASNQISVKSGSVELTGRPMPCLFKINPGTQSSTSHVLVWQT--ESLLPIMEFK 359
            ||. |.|.:.|.|.|......|.::||.:..|...:|......:.:..|.|..  :...||..:.
  Rat   856 VRE-DSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYD 919

  Fly   360 LKFRQIPSNNVTRQVRTNWTELTIPAQATNGLI-YITTYTLHGLQPASLYEVSVLARNSFGWSDN 423
            ::         .:....:|..    ||.|..:. .:.:.|:..:.|:|.|.:.:.|:|..|.|:.
  Rat   920 IE---------CKNKSDSWDS----AQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEP 971

  Fly   424 SKIVRFATGGEVELPNYSTESELQDDFTEEDFHNEITQRSEV 465
            |        .|:.:    |..|...|...::.|.|.|....:
  Rat   972 S--------NEITI----TADEAAPDGPPQEVHLEPTSSQSI 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wrapperNP_477404.1 Ig 41..124 CDD:299845 18/91 (20%)
IG_like 41..118 CDD:214653 17/85 (20%)
IG_like 145..218 CDD:214653 25/86 (29%)
Ig 147..219 CDD:299845 25/85 (29%)
I-set 224..323 CDD:254352 18/107 (17%)
IGc2 236..314 CDD:197706 14/85 (16%)
FN3 339..431 CDD:238020 17/94 (18%)
DscamXP_038943864.1 Ig 26..121 CDD:416386
Ig strand A' 33..37 CDD:409353
Ig strand B 40..49 CDD:409353
Ig strand C 55..61 CDD:409353
Ig strand C' 63..66 CDD:409353
Ig strand D 72..75 CDD:409353
Ig strand E 80..85 CDD:409353
Ig strand F 98..106 CDD:409353
Ig strand G 109..121 CDD:409353
Ig 125..210 CDD:416386
Ig strand A 126..130 CDD:409353
Ig strand A' 132..136 CDD:409353
Ig strand B 139..149 CDD:409353
Ig strand C 157..163 CDD:409353
Ig strand C' 164..167 CDD:409353
Ig strand E 179..185 CDD:409353
Ig strand F 191..201 CDD:409353
IGc2 239..300 CDD:197706
Ig strand B 242..246 CDD:409353
Ig strand C 255..259 CDD:409353
Ig strand F 290..295 CDD:409353
Ig 313..395 CDD:416386
Ig strand A 314..319 CDD:409353
Ig strand A' 322..326 CDD:409353
Ig strand B 329..339 CDD:409353
Ig strand C 344..350 CDD:409353
Ig strand C' 351..354 CDD:409353
Ig strand E 368..374 CDD:409353
Ig strand F 381..389 CDD:409353
Ig 406..501 CDD:416386
Ig strand A 406..409 CDD:409353
Ig strand A' 415..419 CDD:409353
Ig strand B 422..431 CDD:409353
Ig strand C 436..442 CDD:409353
Ig strand C' 444..447 CDD:409353
Ig strand D 452..460 CDD:409353
Ig strand E 464..473 CDD:409353
Ig strand F 480..488 CDD:409353
Ig strand G 491..501 CDD:409353
Ig 504..593 CDD:416386 9/33 (27%)
Ig strand A 505..507 CDD:409353
Ig strand A' 512..516 CDD:409353
Ig strand B 519..526 CDD:409353
Ig strand C 533..539 CDD:409353
Ig strand C' 540..542 CDD:409353
Ig strand D 549..553 CDD:409353
Ig strand E 557..563 CDD:409353 2/3 (67%)
Ig strand F 571..579 CDD:409353 0/7 (0%)
Ig strand G 583..593 CDD:409353 3/9 (33%)
Ig 596..686 CDD:416386 19/95 (20%)
Ig strand A 597..599 CDD:409353 0/1 (0%)
Ig strand B 611..620 CDD:409353 3/8 (38%)
Ig strand C 625..632 CDD:409353 2/7 (29%)
Ig strand C' 634..636 CDD:409353 0/1 (0%)
Ig strand D 643..648 CDD:409353 1/7 (14%)
Ig strand E 651..658 CDD:409353 2/6 (33%)
Ig strand F 665..673 CDD:409353 3/7 (43%)
Ig strand G 676..685 CDD:409353 2/8 (25%)
Ig_DSCAM 689..784 CDD:409397 28/100 (28%)
Ig strand B 707..711 CDD:409397 0/3 (0%)
Ig strand C 720..724 CDD:409397 1/3 (33%)
Ig strand E 749..753 CDD:409397 2/3 (67%)
Ig strand F 763..768 CDD:409397 1/4 (25%)
Ig strand G 777..780 CDD:409397 0/2 (0%)
Ig_DSCAM 785..884 CDD:409398 20/115 (17%)
Ig strand B 805..809 CDD:409398 0/3 (0%)
Ig strand C 818..822 CDD:409398 2/18 (11%)
Ig strand E 848..852 CDD:409398 0/3 (0%)
Ig strand F 862..867 CDD:409398 1/4 (25%)
Ig strand G 875..878 CDD:409398 1/2 (50%)
FN3 885..978 CDD:238020 20/117 (17%)
FN3 986..1083 CDD:238020 3/16 (19%)
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig_3 1287..1363 CDD:404760
Ig strand B 1303..1307 CDD:409353
Ig strand C 1316..1320 CDD:409353
Ig strand E 1342..1346 CDD:409353
Ig strand F 1356..1361 CDD:409353
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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