DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wrapper and ncam2

DIOPT Version :9

Sequence 1:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_012811963.1	Gene:	ncam2 / 100151722	XenbaseID:	XB-GENE-1217730	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	439	Identity:	104/439 - (23%)
Similarity:	193/439 - (43%)	Gaps:	68/439 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QVQAELDF-------NNDLENSQKFKSIPTTVKTYENDTVQLPCTLNTPFRYVRWHRDDVALVDS 77
            :|:.|:||       |...|...:.:|...|....|:.|:....| .:|..|:.|||:...:.::
Frog   220 EVRGEIDFRDISVIVNVPPEILAQQRSFNATADRLEDITLFCRAT-GSPKPYITWHRNGKLVEEN 283

  Fly    78 RHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIEVQLAPQVLIEPSDLT 142
            ...:|..       .|..|.|.|:.|:|:|.|.|...:.:|...:|..::|.:.|.::...::.|
Frog   284 EKYDLRE-------DNTELTVKNIISTDSGLYVCRATNKAGFTEKQSFLQVFVQPHIVQLQNETT 341

  Fly   143 EQRIGAIFEVVCEAQGVPQPVITWR--------LNGNVIQPQ--SNTGNRQSLILEIKS--RNQA 195
            .:. |.: .:.|||:|.|.|.|||:        .:|:..|..  .:||:.....|.|||  .:.|
Frog   342 IEH-GHV-TLTCEAEGEPIPEITWKRSSDGMIFYDGDKSQDGRIESTGHHGKSSLHIKSVMLSDA 404

  Fly   196 GLIECVASNGVGEPAVANVYLHVLFSPEVSIPQPVVYTKLGSRAHLECIVEAAPAATVKWFHHGL 260
            |..:|.|::.:|... .::||::.::|:....|.:.|:...:..::.|.|.:.|.:::.|....|
Frog   405 GRYDCEAASRIGGHQ-KSMYLNIEYAPKFISNQTIYYSWENNPINISCDVTSNPPSSIYWSRDKL 468

  Fly   261 PVALGAHSTTHESELQTNRSVDHYVNAVRHMLVVKSVRNADMGQYECRASNQISVKSGSVELTGR 325
              .|.|.:.|         ::..|.:..|.:|.:..:.:.|.|:|.|.|.|.|..:.....||..
Frog   469 --LLPARNIT---------NIKTYRDGKRILLEITPLSDNDFGRYNCTAINSIGSRIQEYILTLA 522

  Fly   326 PMPCLFKINP----GTQSSTSHVLVW----QTESLLPIMEFKLKFRQIPSNNVTRQVRTNWTELT 382
            .:|.    :|    ..:.|.::..|:    .:...:||..:::.|::: |:.:.:.||::.|:
Frog   523 DVPS----SPYGLRVIELSQTYAKVFFNKPDSHGGVPIHHYQMDFKEV-SSEIWKVVRSHGTQ-- 580

  Fly   383 IPAQATNGLIYITTYTLHGLQPASLYEVSVLARNSFGWSDNSKIVRFAT 431
                        |...|..|...:.|||.|.|.|..|..:.||...|.|
Frog   581 ------------TIIVLGNLDANTTYEVKVAAVNGKGKGEYSKTEIFQT 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wrapper	NP_477404.1	Ig	41..124	CDD:299845	20/82 (24%)
		IG_like	41..118	CDD:214653	19/76 (25%)
		IG_like	145..218	CDD:214653	25/84 (30%)
		Ig	147..219	CDD:299845	25/83 (30%)
		I-set	224..323	CDD:254352	20/98 (20%)
		IGc2	236..314	CDD:197706	17/77 (22%)
		FN3	339..431	CDD:238020	22/95 (23%)
ncam2	XP_012811963.1	Ig	50..141	CDD:386229
		IG_like	150..234	CDD:214653	4/13 (31%)
		Ig	237..330	CDD:386229	24/100 (24%)
		Ig	329..426	CDD:386229	27/99 (27%)
		IG_like	442..520	CDD:214653	18/88 (20%)
		FN3	525..617	CDD:238020	24/110 (22%)
		fn3	623..706	CDD:365830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910