DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rtf1 and RTF1

DIOPT Version :9

Sequence 1:	NP_001286717.1	Gene:	Rtf1 / 37554	FlyBaseID:	FBgn0034722	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	NP_055953.3	Gene:	RTF1 / 23168	HGNCID:	28996	Length:	710	Species:	Homo sapiens

Alignment Length:	808	Identity:	314/808 - (38%)
Similarity:	452/808 - (55%)	Gaps:	176/808 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRRTQSLIDSNSSDSDSESETNLESDLMSLAKKR------KKP---QTAAKSSSR-SDSDSDWA- 56
            ||:.:.:|||::.||.|:.  ||:.:|:||||::      |:|   |.||.|.|. ||||.:|.
Human    44 KRKGRVVIDSDTEDSGSDE--NLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTF 106

  Fly    57 ----NNKAG-APSSKKKKRQKPSRDSSSSESNWDDDSQDERQPARQSPAQTQQEHKPPEQASQPA 116
                |.|.| |...:||...|...:.::|..:.|.||.                          |
Human   107 GSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSS--------------------------A 145

  Fly   117 QLSEQEEGEVSDSDSDKSKSNSSSSGSDSSSSSSSSDSEFDDGFDDDLMGDDEDRRRLNGLSEKE 181
            :.|..|||||||||     ||||||.||  |.|||.|.||.||:.:|||||:|||.||..::|||
Human   146 ESSAPEEGEVSDSD-----SNSSSSSSD--SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKE 203

  Fly   182 RETEIYKRIEQREIMRTRWEIERKLKLARRGEKNQEKSKNKGERAKKKKEKREKKARKAREAQAP 246
            ||.|::.|||:||:::.|:||::|||.|::.||.::|.       |:::|:.:||..:.:|:|.
Human   204 REQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKK-------KQEEEQEKKKLTQIQESQV- 260

  Fly   247 LPTQASTSTLLDVEPKPSNEVRSASPLSTPALNRDAASTSAAVASIMPDDAASSAGVSDYFDHKE 311
                                                  ||                     .:||
Human   261 --------------------------------------TS---------------------HNKE 266

  Fly   312 RSKERKKNVEANKTDDKRSNAMALLKAKREGKAKREEEEAKRMAEKDRDDDKEELDSVSGCKSAV 376
            |..:|.:.:      ||:|.||..|||:||   ||:...|:.:|:|.
Human   267 RRSKRDEKL------DKKSQAMEELKAERE---KRKNRTAELLAKKQ------------------ 304

  Fly   377 KLKASEIYSDDSGSSDWDEEEKPAGKRSRSNSSKASSESEDEEKAPQRPVFITTREDLNKLRLSR 441
            .||.||:||||   .:.:|::|.:.|..||:.:.:|.|.|::|:.|.:...::..|:||::||||
Human   305 PLKTSEVYSDD---EEEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVSLPEELNRVRLSR 366

  Fly   442 YKMERFVNLPIFESTVLNCFVRISIGNNGQKPVYRVAEIVGVVETGKIYSLGTTRTNRGLRLKHG 506
            :|:||:.::|.|..||..|||||.|||:..|||||||||.|||||.|:|.||.||||:||:|:||
Human   367 HKLERWCHMPFFAKTVTGCFVRIGIGNHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHG 431

  Fly   507 TQERVFRLEFISNQEFTENEFNKWNEVCQQSHVQMPTIDLIAIKQNDIKKALNYEFKDEDVDKIV 571
            ..:|||||||:|||||||:||.||.|....:.:|:||:|.|..|:..||:||||:|.|:|:::||
Human   432 NDQRVFRLEFVSNQEFTESEFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIV 496

  Fly   572 EEKNRFRNRPTNYAMKKTCLMKERDAAMLRGDYDIAQDLGQQIDELENRASELDKRRSHTLNLIS 636
            :||.|||..|.|||||||.|:||:..|...||.|.|:.:..|::|||.||..||::|:..::.||
Human   497 KEKERFRKAPPNYAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAIS 561

  Fly   637 YINDRNRKKNVEDAEKAILEEARANKGLKISDPFTRRITQPRMGFKGAKKDEDDMQLA------- 694
            |||.|||:.|:.::|||::.|:...|..:: ||||||..:|.:   .:...:..:|.|
Human   562 YINQRNREWNIVESEKALVAESHNMKNQQM-DPFTRRQCKPTI---VSNSRDPAVQAAILAQLNA 622

  Fly   695 -----PLPPPP----PGKKRPNEAGTSSASVRSTDSKDYSLYSLHDFDIDLDVPLPVNTNSVPKP 750
                 .||..|    .|:.:..:..:.|||..|.|     |:.:||||:.:|:.:|.:.:.....
Human   623 KYGSGVLPDAPKEMSKGQGKDKDLNSKSASDLSED-----LFKVHDFDVKIDLQVPSSESKALAI 682

  Fly   751 ASK--PA-ETVSKRSLNLEDYKKKRGLI 775
            .||  || :...:||||||||||:||||
Human   683 TSKAPPAKDGAPRRSLNLEDYKKRRGLI 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtf1	NP_001286717.1	Plus3	428..535	CDD:197843	68/106 (64%)
RTF1	NP_055953.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..214		84/204 (41%)
		COG5296	189..623	CDD:227615	210/534 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..357		51/225 (23%)
		Plus-3	359..459	CDD:397304	67/99 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	627..650		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..710		16/35 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3793
eggNOG	1	0.900	-	-		E1_COG5296
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133868
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1804
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55546
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003630
OrthoInspector	1	1.000	-	-		oto90838
orthoMCL	1	0.900	-	-		OOG6_103917
Panther	1	1.100	-	-	LDO	PTHR13115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1264
SonicParanoid	1	1.000	-	-		X3500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860