DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and PPFIA3

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_003651.1	Gene:	PPFIA3 / 8541	HGNCID:	9247	Length:	1194	Species:	Homo sapiens

Alignment Length:	1018	Identity:	277/1018 - (27%)
Similarity:	409/1018 - (40%)	Gaps:	267/1018 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 LAQAAGPAHNAPSSGSAL-NAVDKRNANLSEPDQDLPPNLNVNLSPNPSL--ALGAPHSPTSAAS 273
            ||...||..::....:.| .|::::.|.:.:    |...|.|.......|  .||..|.....|.
Human   221 LANGLGPGGDSNRRTAELEEALERQRAEVCQ----LRERLAVLCRQMSQLEEELGTAHRELGKAE 281

  Fly   274 AALLLLE----SCDGNRND-ESRFHHLH----SAPRPEATMKLREENDRLNAELL---------- 319
            .|...|:    .....|.| |.|...|.    ||.| ||| .|.:.||:|..||.
Human   282 EANSKLQRDLKEALAQREDMEERITTLEKRYLSAQR-EAT-SLHDANDKLENELASKESLYRQSE 344

  Fly   320 -RLRRLLELSTDG------AVGGVDTAPEMEAVASGEGSAA----------KERIERLESELRSV 367
             :.|:|.|...|.      .:...:|.||:||..:...:|.          :||:.:||::|..
Human   345 EKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEE- 408

  Fly   368 KNQLLTMRLERKKLRTDKSDLLGQ-VKQLCASLQEKEQELRDFIRNYQERVRETETTNAKISGDR 431
            |||.|....:|:|:..|.:..|.: |.:|.:...|:.|      .:.:||:...|..|:.
Human   409 KNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQ------LHLKERMGALEEKNSL----- 462

  Fly   432 DRERFQLLKQARDEAERSLALAQQLSARDLQLQRLQEQLQEAR--------RQLTGCLSDQESLH 488
             .|....:|:.:||.   |...:||.|   :::|:|.::.:.|        |.|.|  |..|..:
Human   463 -SEEIANMKKLQDEL---LLNKEQLLA---EMERMQMEIDQLRGRPPSSYSRSLPG--SALELRY 518

  Fly   489 SFAPLTPPSAASGMLSQMAAASGMGGGLAGMRGTTEDSGRGNSLSA--------FSGSLSG---- 541
            |.|| |.||.|.  |....|.||..|......|..|:..:....||        |.|.|.|
Human   519 SQAP-TLPSGAH--LDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEE 580

  Fly   542 -GSGATAGDRNSCSNDSGLRN-------------------SSDREST---GGELN---FSDG--- 577
             ..|....:..|.|..:.::.                   ..::|:|   ..||.   .|.|
Human   581 EAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDS 645

  Fly   578 ------TCDNGPCITVDPDSISLVSSQNMYQFGTPKERSPTLSPLNSA------AYSRSVEQLGS 630
                  :|...|.:|.     |.::|.:....|   ..:|.|:|.:.|      |.....|:.|:
Human   646 LGRYRSSCSLPPSLTT-----STLASPSPPSSG---HSTPRLAPPSPAREGTDKANHVPKEEAGA 702

  Fly   631 P----------VDPEGPGNGAISRKF-ANASKSGPL---GARNGRGGT-------------WGSI 668
            |          ..|..|.:..:.|.. |.|.::|.|   |...|..||             ..||
Human   703 PRGEGPAIPGDTPPPTPRSARLERMTQALALQAGSLEDGGPPRGSEGTPDSLHKAPKKKSIKSSI 767

  Fly   669 SRVFARSRNKNK-------ALSADGVTEYADYSWNPLTEEGYAE-------------KLRLLREA 713
            .|:|.: :.|.:       :.|..|.......:.:||   |.|:             |..||.||
Human   768 GRLFGK-KEKGRMGPPGRDSSSLAGTPSDETLATDPL---GLAKLTGPGDKDRRNKRKHELLEEA 828

  Fly   714 SQ--LPIDRWRATQVLAWLEVALGMPQ-YSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKK 775
            .:  ||...|....|::|||:.:|||. |.|.|..|||||.::..|:|.|::..:|:::|:||.|
Human   829 CRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLK 893

  Fly   776 LRLAIEEQ--------------------------------RRPEM--VRYPLITQLG---HTWVA 803
            |||||:|.                                .:||.  :.:..|...|   |.||.
Human   894 LRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVG 958

  Fly   804 TEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDRQT 868
            .:|||.:|||||...|::|||||||||.|:||||...|.:...||:.|:.:||..|:.:.|||:.
Human   959 NDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKD 1023

  Fly   869 LAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMATALG 933
            |..||.:|:|...|.:||:|:|.:.||..:.|.|:|.||.:|||||.|:.|:.:|....:|..|.
Human  1024 LERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQ 1088

  Fly   934 IPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLTGPGGLQHYATTDRRSSGNLRISAW 998
            ||......|:.|..||..||     :||                       ||||...:   ||.
Human  1089 IPTQNAQARQLLEKEFSNLI-----SLG-----------------------TDRRLDED---SAK 1122

  Fly   999 KGSQS-SLSKAFRFNSKPHRTGDRSSFGNSTSPTPSYSSSEGG 1040
            ..|:| |..|.||.......|.|     ::....|::.|:..|
Human  1123 SFSRSPSWRKMFREKDLRGVTPD-----SAEMLPPNFRSAAAG 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	26/106 (25%)
		SAM_kazrin_repeat1	718..787	CDD:188963	30/101 (30%)
		SAM	719..781	CDD:197735	28/62 (45%)
		SAM_kazrin_repeat2	796..860	CDD:188966	33/66 (50%)
		SAM	805..860	CDD:197735	29/54 (54%)
		SAM_kazrin_repeat3	882..953	CDD:188969	28/70 (40%)
		SAM	885..>934	CDD:197735	21/48 (44%)
PPFIA3	NP_003651.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..233		4/11 (36%)
		BAR	237..>419	CDD:299863	49/188 (26%)
		Taxilin	239..499	CDD:286771	70/284 (25%)
		CDC37_N	<398..498	CDD:296150	30/118 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..583		16/59 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..819		42/206 (20%)
		SAM_liprin-alpha1,2,3,4_repeat1	835..905	CDD:188961	30/69 (43%)
		SAM	838..901	CDD:197735	29/62 (47%)
		SAM_liprin-alpha1,2,3,4_repeat2	952..1017	CDD:188964	33/64 (52%)
		SAM	960..1015	CDD:197735	29/54 (54%)
		SAM_liprin-alpha1,2,3,4_repeat3	1037..1108	CDD:188967	28/70 (40%)
		SAM	1040..1107	CDD:197735	27/66 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1194		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810